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New strategies in the pharmacotherapy of neuropathic pain based on modulation of the chemokine system and its influence on opioid tolerance development

2021/43/B/NZ7/00230

Keywords:

neuropathic pain chemokines neuroimmunology microglia astroglia opioid analgesic drugs

Descriptors:

  • NZ7_014:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Joanna Gabriela Mika 

Number of co-investigators in the project: 6

Call: OPUS 22 - announced on 2021-09-15

Amount awarded: 1 923 624 PLN

Project start date (Y-m-d): 2022-07-15

Project end date (Y-m-d): 2026-07-14

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (13)
  1. Phenytoin decreases pain-like behaviors and improves opioid analgesia in a rat model of neuropathic pain
    Authors:
    Kocot-Kępska M, Pawlik K, Ciapała K, Makuch W, Zajączkowska R, Dobrogowski J, Przeklasa-Muszyńska A, Mika J.
    Academic press:
    Brain Sci. (rok: 2023, tom: 13, strony: 46038), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/brainsci13060858 - link to the publication
  2. CC Chemokine Family Members' Modulation as a Novel Approach for Treating Central Nervous System and Peripheral Nervous System Injury-A Review of Clinical and Experimental Findings
    Authors:
    Ciechanowska A, Mika J.
    Academic press:
    Int J Mol Sci. (rok: 2024, tom: 25, strony: 15707), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25073788 - link to the publication
  3. Pharmacological modulation of the MIP-1 family and their receptors reduces neuropathic pain symptoms and influences morphine analgesia: evidence from a mouse model
    Authors:
    Ciechanowska A, Pawlik K, Ciapała K, Mika J.
    Academic press:
    Brain Sci. (rok: 2023, tom: 13, strony: 46046), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/brainsci13040579 - link to the publication
  4. Analgesic effects of fisetin, peimine, astaxanthin, artemisinin, bardoxolone methyl and 740 Y-P and their influence on opioid analgesia in a mouse model of neuropathic pain
    Authors:
    Ciapała K, Rojewska E, Pawlik K, Ciechanowska A, Mika J
    Academic press:
    Int J. Mol Sci. (rok: 2023, tom: 24, strony: 46042), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24109000 - link to the publication
  5. Pharmacological evidence of the important roles of CCR1 and CCR3 and their endogenous ligands CCL2/7/8 in hypersensitivity based on a murine model of neuropathic pain
    Authors:
    Pawlik K, Ciapała K, Ciechanowska A, Kwiatkowski K, Mika J.
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 46050), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12010098 - link to the publication
  6. A New Application for Cenicriviroc, a Dual CCR2/CCR5 Antagonist, in the Treatment of Painful Diabetic Neuropathy in a Mouse Model
    Authors:
    Bober A, Piotrowska A, Pawlik K, Ciapała K, Maciuszek M, Makuch W, Mika J.
    Academic press:
    Int J Mol Sci. (rok: 2024, tom: 25, strony: 46044), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25137410 - link to the publication
  7. A Missing Puzzle in Preclinical Studies-Are CCR2, CCR5, and Their Ligands' Roles Similar in Obesity-Induced Hypersensitivity and Diabetic Neuropathy?-Evidence from Rodent Models and Clinical Studies
    Authors:
    Bober A, Mika J, Piotrowska A.
    Academic press:
    Int J Mol Sci. (rok: 2024, tom: 25, strony: 46039), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms252011323 - link to the publication
  8. Targeting members of the chemokine family as a novel approach to treating neuropathic pain.
    Authors:
    Pawlik K, Mika J
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 15707), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28155766 - link to the publication
  9. New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies
    Authors:
    Ciechanowska A, Rojewska E, Piotrowska A, Barut J, Pawlik K, Ciapała K, Kreiner G, Mika J.
    Academic press:
    Front Immunol. (rok: 2022, tom: 13, strony: 46043), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.1058204 - link to the publication
  10. Mirogabalin decreases pain-like behaviors by inhibiting the microglial/macrophage activation, p38MAPK signaling, and pronociceptive CCL2 and CCL5 release in a mouse model of neuropathic pain
    Authors:
    Zajączkowska R, Pawlik K, Ciapała K, Piotrowska A, Ciechanowska A, Rojewska E, Kocot-Kępska M, Makuch W, Wordliczek J, Mika J
    Academic press:
    Pharmaceuticals (rok: 2023, tom: 16, strony: 46035), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph16071023 - link to the publication
  11. CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy.
    Authors:
    Bogacka J, Pawlik K, Ciapała K, Ciechanowska A, Mika J.
    Academic press:
    Int J Mol Sci (rok: 2022, tom: 23, strony: 46042), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232415638 - link to the publication
  12. Advances in neuropathic pain research: selected intracellular factors as potential targets for multidirectional analgesics.
    Authors:
    Ciapała K, Mika J.
    Academic press:
    Pharmaceuticals (rok: 2023, tom: 16, strony: 46046), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph16111624 - link to the publication
  13. Astaxanthin has a beneficial influence on pain-related symptoms and opioid-induced hyperalgesia in mice with diabetic neuropathy-evidence from behavioral studies
    Authors:
    Ciapała K, Pawlik K, Ciechanowska A, Makuch W, Mika J.
    Academic press:
    Pharmacol Rep. (rok: 2024, tom: 76, strony: 1346-1362), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-024-00671-9 - link to the publication

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