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Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of opioid receptors in arterial hypertension. Examination of hypotensive action of biphalin, a synthetic non-addtictive opioid, in different hypertension models in the rat. Comparison with effects of morphine.

2011/03/B/NZ4/02162

Keywords:

arterial hypertension biphalin morphine

Descriptors:

  • NZ4_2: Physiology
  • NZ4_4: Pathophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Janusz Sadowski 

Number of co-investigators in the project: 4

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 439 450 PLN

Project start date (Y-m-d): 2012-09-14

Project end date (Y-m-d): 2015-03-13

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Dwukanałowy przepływomierz Transonic typ 402 z dwoma modułami typu TS420 (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. An antihypertensive opioid: biphalin, a synthetic non-addictive enkephalin analog decreases blood pressure in spontaneously hypertensive rats
    Authors:
    Bądzyńska B., Lipkowski AW., Sadowski J
    Academic press:
    Pharmacological Reports (rok: 2016, tom: 68, strony: 51-55), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Different blood pressure responses to opioids in 3 rat hypertension models: role of the baseline status of sympathetic and renin-angiotensin systems
    Authors:
    Bożena Bądzyńska, Andrzej W. Lipkowski, Krzysztof H. Olszyński , Janusz Sadowski1
    Academic press:
    Can J Physiol Pharmacol (rok: 2016, tom: 94, strony: 1159-1169), Wydawca: NRC Research Press
    Status:
    Published
    DOI:
    10.1139/cjpp-2016-0111 - link to the publication
  1. Biphalin, a non-addictive synthetic opioid, is hypotensive and improves renal perfusion in anaesthetised spontaneously hypertensive rats.
    Authors:
    Bądzyńska B, Olszyński KH, Lipkowski AW, Sadowski J.
    Conference:
    50th ERA-EDTA Congress Nephrology Dialysis and Transplantation (rok: 2013, ), Wydawca: Oxford Journals
    Data:
    konferencja 18-21 maja
    Status:
    Published

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