Projects funded by the NCN

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Information of the project and the call

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Determination of the mechanisms and potential targets for neuropathic pain therapy by investigating pharmacological interactions occurring between substances that modulates glial cells activity and opioid analgesics.

2016/23/N/NZ7/00356

Keywords:

neuropathic pain CCR5 CXCR3 chemokines interleukins opioids

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Anna Piotrowska-Murzyn 

Number of co-investigators in the project: 3

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 149 400 PLN

Project start date (Y-m-d): 2017-08-17

Project end date (Y-m-d): 2022-08-16

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (10)
  1. Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury
    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kreiner G., Ciechanowska A., Makuch W., Nalepa I, Mika J.
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 10, strony: 45313), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.02198 - link to the publication
  2. Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies.
    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kreiner G., Ciechanowska A., Makuch W., Zychowska M, Mika J.
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (rok: 2018, tom: 1864, strony: 3418-3437), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2018.07.032. - link to the publication
  3. Comparison of the Effects of Chemokine Receptors CXCR2 and CXCR3 Pharmacological Modulation in Neuropathic Pain Model-In Vivo and In Vitro Study.
    Authors:
    Piotrowska A., Ciapała K., Pawlik K., Kwiatkowski K., Rojewska E., Mika J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 11074), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222011074 - link to the publication
  4. Dataset of (±)-NBI-74330 (CXCR3 antagonist) influence on chemokines under neuropathic pain
    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kreiner G., Ciechanowska A., Makuch W., Mika J.
    Academic press:
    Data in Brief (rok: 2018, tom: 21, strony: 1145–1150), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.091 - link to the publication
  5. New insights into the analgesic properties of the XCL1/XCR1 and XCL1/ITGA9 axes modulation under neuropathic pain conditions - evidence from animal studies.
    Authors:
    Ciechanowska A., Rojewska E., Piotrowska A., Barut J., Pawlik K., Ciapała K., Kreiner G., Mika J.
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 1058204), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.1058204 - link to the publication
  1. Antagoniści receptorów chemokinowych jako modulatory komórek glejowych w bólu neuropatycznym.
    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kwiatkowski K., Ciechanowska A., Makuch W., Mika J.
    Conference:
    VII SYMPOZJUM "POSTĘPY W LECZENIU BÓLU" (rok: 2018, ), Wydawca: INDEX COPERNICUS
    Data:
    konferencja 4-6.10.2018
    Status:
    Published
  2. Blockade of CXCR3 by (±)-NBI-74330 inhibits neuropathic pain in rats by modulating release of CXCR3 ligands.
    Authors:
    Piotrowska A, Rojewska E, Zychowska M., Makuch W., Mika J.
    Conference:
    Neuronus 2018 (rok: 2018, ), Wydawca: Neuronus IBRO NEUROSCIENCE FORUM
    Data:
    konferencja 20-22.04.2018
    Status:
    Published
  3. Comparison of antinociceptive effects of CXCR2 and CXCR3 receptor antagonists and their influence on opioids analgesia of neuropathic pain model.
    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Ciechanowska A., Makuch W., Mika J.
    Conference:
    Pain in Europe XI, 11th Congress of the European Pain Federation EFIC, Walencja, Hiszpania (rok: 2019, ), Wydawca: EFIC
    Data:
    konferencja 2019-09-4-7
    Status:
    Published
  4. Comparison of pharmacological modulation of glial cells by the CCR5 and CXCR3 receptor antagonists –in vivo and in vitro studies
    Authors:
    Piotrowska-Murzyn A., Kwiatkowski K., Rojewska E., Pawlik K., Ciechanowska A., Mika J.
    Conference:
    European Meeting on Glial Cells in Health and Disease (rok: 2019, ), Wydawca: Wiley Online Library
    Data:
    konferencja 2019-07-10-13
    Status:
    Published
  5. Porównanie wpływu farmakologicznej modulacji receptorów chemokinowych z rodziny CXC na proces nocycepcji w bólu neuropatycznym.
    Authors:
    Piotrowska-Murzyn A., Rojewska E., Pawlik K., Ciechanowska A., Mika J.
    Conference:
    VIII Sympozjum "Postępy w leczeniu bólu" Polskiego Towarzystwa Badania Bólu (rok: 2021, ), Wydawca: medycyna praktyczna mp.pl
    Data:
    konferencja 18-27.11.2021
    Status:
    Published
  6. Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain.
    Authors:
    Pawlik K., Piotrowska A., Rojewska E., Ciechanowska A., Makuch W., Mika J.
    Conference:
    3rd Central European Biomedical Congress (rok: 2018, ), Wydawca: CEBC, Kraków 2018
    Data:
    konferencja 15-18.09.2018
    Status:
    Published
  7. The effects of opioids on immune system – the role of glial cells in the development of opioid tolerance and OIH in the model of neuropathic pain.
    Authors:
    Piotrowska A., Bogacka J., Starnowska-Sokół J., Ciapała K., Przewłocka B.
    Conference:
    12th Congress of the European Pain Federation EFIC (rok: 2022, ), Wydawca: EFIC
    Data:
    konferencja 27.04-01.05.2022
    Status:
    Published
  8. Blockade of CXCR2 inhibits neuropathic pain – related behavior and modulates primary microglial and astroglia culture
    Authors:
    Pawlik K., Piotrowska A., Rojewska E., Ciechanowska A., Makuch W., Mika J.
    Conference:
    European Meeting on Glial Cells in Health and Disease (rok: 2019, ), Wydawca: Wiley Online Library
    Data:
    konferencja 2019-07-10-13
    Status:
    Published
  9. CXCR3 receptor as new target to treat neuropathic pain: efficacy of a receptor antagonist in in vitro and in vivo studies
    Authors:
    Piotrowska A., Kwiatkowski K., Rojewska E., Pawlik K., Ciechanowska A., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research "From Lab to clinic" (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 2019-06-22-27
    Status:
    Published
  10. The (±)-NBI-74330 (CXCR3 antagonist) reduces neuropathic pain and influences the level of nociceptive factors – evidence from in vivo and in vitro studies
    Authors:
    Pawlik K., Piotrowska A., Rojewska E., Popiołek- Barczyk K., Mika J.
    Conference:
    Neuronus 2018 (rok: 2018, ), Wydawca: Neuronus IBRO NEUROSCIENCE FORUM
    Data:
    konferencja 20-22.04.2018
    Status:
    Published

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