Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New strategies in neuropathic pain pharmacotherapy based on the modulation of the functions of chemokine receptors CCR2 and CCR5

2018/29/N/NZ7/00287

Keywords:

pain neuropathy chemokines CCR2 CCR5 pharmacotherapy maraviroc RS504393 cenicriviroc bindarit opioids

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Klaudia Kwiatkowski 

Number of co-investigators in the project: 3

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 209 900 PLN

Project start date (Y-m-d): 2019-02-06

Project end date (Y-m-d): 2023-02-05

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat Mini-PROTEAN do poczwórnej pionowej elektroforezy (2 600 PLN)
  2. Aparat do elektroforezy z wykorzystaniem żeli Criterion (2 700 PLN)
  3. Ogranicznik dla gryzoni z oświetlaczem ogona do podań dożylnych (4 114 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. Bidirectional action of cenicriviroc, a CCR2/CCR5 antagonist, results in alleviation of pain-related behaviors and potentiation of opioid analgesia in rats with peripheral neuropathy.
    Authors:
    Kwiatkowski K., Pawlik K., Ciapała K., Piotrowska A., Makuch W., Mika J.
    Academic press:
    Front. Immunol. (rok: 2020, tom: 11, strony: 615327(1-16)), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.615327 - link to the publication
  2. Pharmacological Evidence of the Important Roles of CCR1 and CCR3 and Their Endogenous Ligands CCL2/7/8 in Hypersensitivity Based on a Murine Model of Neuropathic Pain.
    Authors:
    Pawlik K, Ciapała K, Ciechanowska A, Kwiatkowski K, Mika J.
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 98), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12010098 - link to the publication
  3. Comparison of the beneficial effects of RS504393, maraviroc and cenicriviroc on neuropathic pain-related symptoms in rodents: behavioral and biochemical analyses.
    Authors:
    Kwiatkowski K. Ciapała K., Rojewska E., Makuch W., Mika J.
    Academic press:
    Int Immunopharmacol. (rok: 2020, tom: 84, strony: 106540 (1-12)), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.intimp.2020.106540. - link to the publication
  1. Czy leki antyretrowirusowe mogą działać przeciwbólowo? Rola CCR5 w bólu neuropatycznym.
    Authors:
    Kwiatkowski K., Ciapała K., Popiolek-Barczyk K., Piotrowska A., Makuch W., Mika J.
    Conference:
    X Zjazd Polskiego Towarzystwa Badania Bólu – MEDYCYNA BÓLU 2019 (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 2019-09-26-28
    Status:
    Published
  2. The dual CCR2/CCR5 antagonist, Cenicriviroc, attenuated neuropathic pain-related behavior and enhanced morphine effectiveness.
    Authors:
    Ciapała K., Kwiatkowski K., Makuch W., Mika J.
    Conference:
    Pain in Europe XI, 11th Congress of the European Pain Federation EFIC, Walencja, Hiszpania (rok: 2019, ), Wydawca: EFIC
    Data:
    konferencja 2019-09-4-7
    Status:
    Published
  3. Involvement of chemokines CCL2 and CCL7 in pathogenesis of neuropathic pain in mice.
    Authors:
    Kwiatkowski K., Popiolek-Barczyk K., Rojewska E., Makuch W., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research "From Lab to clinic" (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 2019-06-22-27
    Status:
    Published
  4. Comparison of analgesic effects of maraviroc, RS504393 and cenicriviroc in rodents after sciatic nerve injury based on behavioral and molecular studies.
    Authors:
    Kwiatkowski K., Ciapała K., Popiołek-Barczyk K., Makuch W., Mika J.
    Conference:
    Pain in Europe XI, 11th Congress of the European Pain Federation EFIC, Walencja, Hiszpania (rok: 2019, ), Wydawca: EFIC
    Data:
    konferencja 2019-09-4-7
    Status:
    Published

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