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Information on the principal investigator and host institution

Information of the project and the call

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Examine the importance of intracellular pathways in the action of opioids in microglial cells in vitro

2012/07/N/NZ3/00379

Keywords:

microglia opioids biphalin minocycline immunomodulatory substances drugs and analgesics

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ3_6: Cell neurobiology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Katarzyna Popiołek-Barczyk 

Number of co-investigators in the project: 3

Call: PRELUDIUM 4 - announced on 2012-09-15

Amount awarded: 149 926 PLN

Project start date (Y-m-d): 2013-07-15

Project end date (Y-m-d): 2017-07-14

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (8)
  1. Modification of neuroimmunological interactions by minocycline: experimental background for neuropathic pain treatment
    Authors:
    Ewelina Rojewska, Katarzyna Popiołek-Barczyk, Joanna Starnowska
    Academic press:
    Annual Report (rok: 2015, tom: 1, strony: 75-78), Wydawca: Polish Academy of Science
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy
    Authors:
    Katarzyna Popiolek-Barczyk, Natalia Kolosowska, Anna Piotrowska, Wioletta Makuch, Ewelina Rojewska, Agnieszka M. Jurga, Dominika Pilat, Joanna Mika
    Academic press:
    Neural Plasticity (rok: 2015, tom: 2015, strony: 45306), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2015/676473 - link to the publication
  3. Delta-Opioid Receptor Analgesia Is Independent of Microglial Activation in a Rat Model of Neuropathic Pain
    Authors:
    Joanna Mika, Katarzyna Popiolek-Barczyk, Ewelina Rojewska, Wioletta Makuch, Katarzyna Starowicz, Barbara Przewlocka
    Academic press:
    PLoS One (rok: 2014, tom: 9, strony: e104420), Wydawca: PLoS One
    Status:
    Published
    DOI:
    10.1371/journal.pone.0104420 - link to the publication
  4. Biphalin, a dimeric enkephalin, alleviates LPS-induced activation in rat primary microglial cultures in opioid receptor-dependent and -independent manners
    Authors:
    Katarzyna Popiolek-Barczyk, Anna Piotrowska, Wioletta Makuch, Joanna Mika
    Academic press:
    Neural Plasticity (rok: 2017, tom: 2017, strony: 3829472), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/3829472 - link to the publication
  5. Comparison of the molecular actions of Botulinum toxin type A and minocycline in lipopolysaccharide-stimulated rat microglial and astroglial cultures
    Authors:
    Anna Piotrowska, Katarzyna Popiołek‐Barczyk, Flaminia Pavone, Joanna Mika
    Academic press:
    Frontiers in Cellular and Infection Microbiology (rok: 2017, tom: 0,389583333333333, strony: eCollection 2017.), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcimb.2017.00141 - link to the publication
  6. Minocycline Enhances the Effectiveness of Nociceptin/Orphanin FQ during Neuropathic Pain
    Authors:
    Katarzyna Popiolek-Barczyk, Ewelina Rojewska, Agnieszka M. Jurga, Wioletta Makuch, Ferenz Zador, Anna Borsodi, Anna Piotrowska, Barbara Przewlocka, Joanna Mika
    Academic press:
    BioMed Research International (rok: 2014, tom: 2014, strony: 45303), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2014/762930. - link to the publication
  7. Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain.
    Authors:
    Katarzyna Popiolek-Barczyk, Joanna Mika
    Academic press:
    Current Medicinal Chemistry (rok: 2016, tom: 23, strony: 2908-2928), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867323666160607120124 - link to the publication
  1. The effects of minocycline on pro- and anti-inflammatory factors after LPS stimulation in primary cultures of rat microglia.
    Authors:
    Katarzyna Popiołek-Barczyk, Joanna Ślusarczyk, Agnieszka Basta-Kaim, Joanna Mika
    Conference:
    NEURONUS 2014 IMBR and IRUN neuroscience forum (rok: 2014, ), Wydawca: neuronusforum.pl
    Data:
    konferencja 25-27.04.2014
    Status:
    Published
    DOI:
    link to the publication
  2. The presence of mu- and kappa- but not delta- opioid receptors on microglia weakens analgesia after selective ligands in rat model of neuropathic pain
    Authors:
    Joanna Mika, Ewelina Rojewska, Katarzyna Popiołek-Barczyk, Wioletta Makuch, Katarzyna Starowicz, Barbara Przewłocka
    Conference:
    7th World Congress, World Institute of Pain (rok: 2014, ), Wydawca: Wiley
    Data:
    konferencja 7-10.05.2014
    Status:
    Published
    DOI:
    link to the publication
  3. The effects of minocycline on microglial cell activation – in vivo and in vitro studies
    Authors:
    Katarzyna Popiołek-Barczyk, Anna Piotrowska, Agnieszka Jurga, Ewelina Rojewska, Joanna Ślusarczyk, Agnieszka Basta-Kaim, Joanna Mika
    Conference:
    15th Congress of Polish Society of Experimental and Clinical Immunology (rok: 2014, ), Wydawca: Termedia Publishing House
    Data:
    konferencja 26-28.06.2014
    Status:
    Published
  4. Biphalin, a dimeric enkephalin, alleviates LPS-induced activation in rat primary microglial cultures in opioid receptor-dependent and -independent manners
    Authors:
    Katarzyna Popiolek-Barczyk, Anna Piotrowska, Wioletta Makuch, Joanna Mika
    Conference:
    XIII European Meeting on Glial Cells in Health and Disease (rok: 2017, ), Wydawca: Wiley E-Only Supplement to Glia
    Data:
    konferencja 8-11.07.2017
    Status:
    Published
  5. Effects of microglial cell polarization on nociception and morphine-analgesia – in vivo and in vitro studies.
    Authors:
    Katarzyna Popiołek-Barczyk, Anna Piotrowska, Natalia Kołosowska, Ewelina Rojewska, Wioletta Makuch, Dominika Piłat, Agnieszka Jurga, Joanna Mika
    Conference:
    Neurochemical Conference 2015 (rok: 2015, ), Wydawca: Mossakowski Medical Research PAS
    Data:
    konferencja 22-23.11.2015
    Status:
    Published
  6. Parthenolide, inhibitor of NF-kB, diminishes neuropathic pain through modulation of microglia polarization.
    Authors:
    Anna Piotrowska, Katarzyna Popiolek-Barczyk, Natalia Kolosowska, Wioletta Makuch, Ewelina Rojewska, Agnieszka M. Jurga, Dominika Pilat, Joanna Mika
    Conference:
    European Pain Federation, Krakow Pain School (rok: 2017, ), Wydawca: Index Copernicus
    Data:
    konferencja 25-29.06.2017
    Status:
    Published
  7. The role of microglia in opioid analgesia - in vivo and in vitro studies
    Authors:
    Katarzyna Popiolek-Barczyk, Ewelina Rojewska, Wioletta Makuch, Katarzyna Starowicz-Bubak, Barbara Przewlocka, Joanna Mika
    Conference:
    NEURONUS 2015 IMBR and IRUN neuroscience forum (rok: 2015, ), Wydawca: neuronusforum.pl
    Data:
    konferencja 17-19.04.2015
    Status:
    Published
    DOI:
    link to the publication
  8. EFFECT OF BOTULINUM TOXIN TYPE A AND MINOCYCLINE ON LIPOPOLYSACCHARIDE-STIMULATED RAT MICROGLIAL AND ASTROGLIAL CULTURES.
    Authors:
    Anna Piotrowska, Katarzyna Popiołek Barczyk, Flaminia Pavone, Joanna Mika
    Conference:
    XIII European Meeting on Glial Cells in Health and Disease (rok: 2017, ), Wydawca: Wiley E-Only Supplement to Glia
    Data:
    konferencja 8-11.07.2017
    Status:
    Published

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