Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Impact of opioid-neurotensin chimera (PK20) on inflammation in murine model of contact sensitivity reaction and non-athopic asthma-comparison with action of neurotensin and endomorphin 2 pharmacophore.

2014/13/B/NZ7/02247

Keywords:

contact sensitivity response inflammation chimerical peptides

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects
  • NZ6_3: Animal immunology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Kaczyńska 

Number of co-investigators in the project: 5

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 349 000 PLN

Project start date (Y-m-d): 2015-01-26

Project end date (Y-m-d): 2017-01-25

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikroskop świetlny firmy Zeiss z kamerą, komputerem i oprogramowaniem (Zeiss) (20 000 PLN)
  2. Iluminator NOVAFLEX firmy WPI (6 000 PLN)
  3. Wirówka cytologiczna- Cytospin 4 (Thermo Shandon) (49 140 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. Murine models of hapten-induced asthma
    Authors:
    Russjan E, Kaczyńska K.
    Academic press:
    Toxicology (rok: 2018, tom: 410, strony: 41-48), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tox.2018.09.001 - link to the publication
  2. Neurotensin-based hybrid peptide's anti-inflammatory activity in murine model of a contact sensitivity response.
    Authors:
    Kaczyńska K, Kogut E, Zając D. Jampolska M, Andrzejewski K, Sulejczak D, Lipkowski AW, Kleczkowska P.
    Academic press:
    European Journal of Pharmaceutical Sciences (rok: 2016, tom: 93, strony: 84-89), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2016.08.012 - link to the publication
  3. Cardiovascular and respiratory activity of PK20, opioid and neurotensin hybrid peptide in anesthetized and awake rats.
    Authors:
    Kaczyńska K, Wojciechowski P, Jampolska M, Lipkowski AW, Kleczkowska P.
    Academic press:
    European Journal of Pharmacology (rok: 2017, tom: 797, strony: 20-25), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2017.01.010 - link to the publication
  1. Anti-inflammatory activity of neurotensin-peptide hybrid in murine model of contact sensitivity response
    Authors:
    Kaczyńska K, Kogut E, Zając D, Jampolska M, Sulejczak D, Lipkowski A, Kleczkowska P.
    Conference:
    7th European Congress of Pharmacology (rok: 2016, ), Wydawca: The Federation of European Pharmacological Societies
    Data:
    konferencja 26-30 VI
    Status:
    Published
  2. Cardiorespiratory activity of PK20, a potent anti-inflammatory and antinociceptive hybrid peptide
    Authors:
    P. Wojciechowski, P. Kleczkowska, K. Kaczyńska
    Conference:
    •Neurochemical Conference 2015 "Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics. (rok: 2015, ), Wydawca: Folia Neuropathol 2015; 53 (4): 395-438
    Data:
    konferencja 22-23 X
    Status:
    Published
    DOI:
    link to the publication
  3. Treatment with neurotensin-opioid hybrid peptide alleviate inflammation in murine model of contact sensitivity reaction and non-atopic asthma-preliminary results.
    Authors:
    E. Kogut, K. Kaczyńska, A. Lipkowski, P. Kleczkowska.
    Conference:
    The 13th International Symposium. Molecular basis of pathology and therapy in neurological disorders. The 4th International Conference. Stem cells: therapeutic outlook for central nervous system disorders. (rok: 2016, ), Wydawca: Termedia Publishing House, Folia neuropathologica
    Data:
    konferencja 17-18 XI
    Status:
    Published
    DOI:
    link to the publication
  4. Opioid-neurotensin hybrid influences pulmonary inflammatory process in murine model of non-atopic asthma.
    Authors:
    Kogut E, Kaczyńska K, Lipkowski W, Kleczkowska P.
    Conference:
    European Respiratory Society Congress 2017 (rok: 2017, ), Wydawca: European Respiratory Society, European Respiratory Journal
    Data:
    konferencja 9-13 IX 2017, Mediolan
    Status:
    Published
    DOI:
    link to the publication

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