Impact of opioid-neurotensin chimera (PK20) on inflammation in murine model of contact sensitivity reaction and non-athopic asthma-comparison with action of neurotensin and endomorphin 2 pharmacophore.
2014/13/B/NZ7/02247
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ7_16: Inne zagadnienia pokrewne
- NZ6_3: Immunologia zwierząt
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 5
Call
OPUS 7 – announced on 2014-03-17
- Amount awarded
- 349 000 PLN
- Project start date
- 2015-01-26
- Project end date
- 2017-01-25
- Project duration
- 24 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Iluminator NOVAFLEX firmy WPI. Cost: 6 000 PLN
- Mikroskop świetlny firmy Zeiss z kamerą, komputerem i oprogramowaniem (Zeiss). Cost: 20 000 PLN
- Wirówka cytologiczna- Cytospin 4 (Thermo Shandon). Cost: 49 140 PLN
Information in the final report
Publication in academic press/journals (3)
-
Murine models of hapten-induced asthma
- Authors:
- Russjan E, Kaczyńska K.
- Academic press:
- Toxicology (year: 2018, volume: 410, pages: 41-48), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.tox.2018.09.001 – link to the publication
-
Cardiovascular and respiratory activity of PK20, opioid and neurotensin hybrid peptide in anesthetized and awake rats.
- Authors:
- Kaczyńska K, Wojciechowski P, Jampolska M, Lipkowski AW, Kleczkowska P.
- Academic press:
- European Journal of Pharmacology (year: 2017, volume: 797, pages: 20-25), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ejphar.2017.01.010 – link to the publication
-
Neurotensin-based hybrid peptide's anti-inflammatory activity in murine model of a contact sensitivity response.
- Authors:
- Kaczyńska K, Kogut E, Zając D. Jampolska M, Andrzejewski K, Sulejczak D, Lipkowski AW, Kleczkowska P.
- Academic press:
- European Journal of Pharmaceutical Sciences (year: 2016, volume: 93, pages: 84-89), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ejps.2016.08.012 – link to the publication
Articles in post-conference publications (4)
-
Opioid-neurotensin hybrid influences pulmonary inflammatory process in murine model of non-atopic asthma.
- Authors:
- Kogut E, Kaczyńska K, Lipkowski W, Kleczkowska P.
- Conference:
- European Respiratory Society Congress 2017 (year: 2017, pages: Eur Respir J, 50 (suppl 61), PA1047), Publisher: European Respiratory Society, European Respiratory Journal
- Date:
- conference 9-13 IX 2017, Mediolan
- Status:
- Published
- DOI:
- link to the publication
-
Anti-inflammatory activity of neurotensin-peptide hybrid in murine model of contact sensitivity response
- Authors:
- Kaczyńska K, Kogut E, Zając D, Jampolska M, Sulejczak D, Lipkowski A, Kleczkowska P.
- Conference:
- 7th European Congress of Pharmacology (year: 2016, pages: 373), Publisher: The Federation of European Pharmacological Societies
- Date:
- conference 26-30 VI
- Status:
- Published
-
Cardiorespiratory activity of PK20, a potent anti-inflammatory and antinociceptive hybrid peptide
- Authors:
- P. Wojciechowski, P. Kleczkowska, K. Kaczyńska
- Conference:
- •Neurochemical Conference 2015 Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics. (year: 2015, pages: 436-437), Publisher: Folia Neuropathol 2015; 53 (4): 395-438
- Date:
- conference 22-23 X
- Status:
- Published
- DOI:
- link to the publication
-
Treatment with neurotensin-opioid hybrid peptide alleviate inflammation in murine model of contact sensitivity reaction and non-atopic asthma-preliminary results.
- Authors:
- E. Kogut, K. Kaczyńska, A. Lipkowski, P. Kleczkowska.
- Conference:
- The 13th International Symposium. Molecular basis of pathology and therapy in neurological disorders. The 4th International Conference. Stem cells: therapeutic outlook for central nervous system disorders. (year: 2016, pages: Folia Neuropathol. 2016, 54/3, p. 315), Publisher: Termedia Publishing House, Folia neuropathologica
- Date:
- conference 17-18 XI
- Status:
- Published
- DOI:
- link to the publication