Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Search for new targets for an effective therapy of neuropathic pain and enhancement of opioids effects basing on the examination and modulation of changes in chemokine systems.

2016/21/B/NZ4/00128

Keywords:

neuropathic pain chemokines neuroimmunology microglia analgesic drugs

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ4_7: Neurophysiology
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Joanna Mika 

Number of co-investigators in the project: 6

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 307 830 PLN

Project start date (Y-m-d): 2017-02-13

Project end date (Y-m-d): 2022-02-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator do hodowli komórkowych.
  2. Automatyczny wielodetekcyjny czytnik SPARK M10 firmy TECAN Austria (158 118 PLN)
  3. Mikroscop odwrócony.

Information in the final report

  • Publication in academic press/journals (23)
  • Articles in post-conference publications (42)
  1. Blockade of CC chemokine receptor type 3 diminishes pain and enhances opioid analgesic potency in a model of neuropathic pain
    Authors:
    Pawlik K., Ciechanowska A., Ciapała K., Rojewska E., Makuch W., Mika J.
    Academic press:
    Front. Immunol. (rok: 2021, tom: 12, strony: 781310 (1-20)), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.781310 - link to the publication
  2. Comparison of the effects of chemokine receptors CXCR2 and CXCR3. Pharmacological modulation in neuropathic pain model – in vivo and in vitro study
    Authors:
    Piotrowska A., Ciapała K., Pawlik K., Kwiatkowski K., Rojewska E., Mika J.
    Academic press:
    Int J Mol Sci. (rok: 2021, tom: 22, strony: 11074 (1-24)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222011074 - link to the publication
  3. Dataset of (±)-NBI-74330 (CXCR3 antagonist) influence on chemokines under neuropathic pain
    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kreiner G., Ciechanowska A., Makuch W., Mika J.
    Academic press:
    Data in Brief (rok: 2018, tom: 21, strony: 1145–1150), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.091 - link to the publication
  4. Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model.
    Authors:
    Rojewska E, Ciapała K, Mika J.
    Academic press:
    Pharmacol Rep. (rok: 2019, tom: 71(1), strony: 139-148), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.002 - link to the publication
  5. Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies.
    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kreiner G., Ciechanowska A., Makuch W., Zychowska M, Mika J.
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (rok: 2018, tom: 1864, strony: 3418-3437), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2018.07.032 - link to the publication
  6. Blockade of CCR4 diminishes hypersensitivity and enhances opioid analgesia - evidence from a mouse model of diabetic neuropathy
    Authors:
    Bogacka J., Ciapała K., Pawlik K., Dobrogowski J., Przeklasa-Muszynska A., Mika J.
    Academic press:
    Neuroscience (rok: 2020, tom: 441, strony: 77-92), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2020.06.025 - link to the publication
  7. Involvement of microglial cells in the antinociceptive effects of metamizol in a mouse model of neuropathic pain
    Authors:
    Zajaczkowska R., Popiolek- Barczyk K., Pilat D., Rojewska E., Makuch W., Wordliczek J., Mika J.
    Academic press:
    Pharmacology Biochemistry and Behavior (rok: 2018, tom: 175, strony: 77-78), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pbb.2018.09.008 - link to the publication
  8. The RS504393 influences the level of nociceptive factors and enhances opioid analgesic potency in neuropathic rats
    Authors:
    Kwiatkowski K., Piotrowska A., Rojewska E., Makuch W., Mika J.
    Academic press:
    J Neuroimmune Pharmacol (rok: 2017, tom: 12, strony: 402-419), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11481-017-9729-6 - link to the publication
  9. The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain
    Authors:
    Pawlik K., Piotrowska A., Kwiatkowski K., Ciapała K., Popiolek-Barczyk K., Makuch W., Mika J.
    Academic press:
    Immunology (rok: 2020, tom: 159(4), strony: 413-428), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/imm.13172 - link to the publication
  10. Comparison of the beneficial effects of RS504393, maraviroc and cenicriviroc on neuropathic pain-related symptoms in rodents: behavioral and biochemical analyses
    Authors:
    Kwiatkowski K. Ciapała K., Rojewska E., Makuch W., Mika J.
    Academic press:
    Int Immunopharmacol. (rok: 2020, tom: 84, strony: 106540 (1-12)), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.intimp.2020.106540 - link to the publication
  11. Comparison of the expression changes after Botulinum toxin type A and minocycline administration in lipopolysaccharide-stimulated rat microglial and astroglial cultures
    Authors:
    Piotrowska A., Popiolek-Barczyk K., Pavone F., Mika J
    Academic press:
    Frontiers in Cellular and Infection Microbiology (rok: 2017, tom: 7, strony: 45308), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcimb.2017.00141 - link to the publication
  12. Involvement of macrophage inflammatory protein-1 (MIP-1) family members in the development of diabetic neuropathy and their contribution to effectiveness of morphine
    Authors:
    Rojewska E., Zychowska M., Piotrowska A., Kreiner G., Nalepa I., Mika J.
    Academic press:
    Frontiers in Immunology (rok: 2018, tom: 9, strony: 21), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.00494/abstract - link to the publication
  13. Tapentadol – A representative of a new class of MOR-NRI analgesics
    Authors:
    Zajaczkowska R., Przewlocka B., Kocot- Kępska M., Mika J., Leppert W., Wordliczek J.
    Academic press:
    Pharmacological Reports (rok: 2018, tom: 70, strony: 812-820), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.01.005 - link to the publication
  14. CCR4 antagonist (C021) influences the level of nociceptive factors and enhances the analgesic potency of morphine in a rat model of neuropathic pain.
    Authors:
    Bogacka J., Popiolek-Barczyk K., Pawlik K., Ciechanowska A., Makuch W., Rojewska E., Dobrogowski J., Przeklasa-Muszynska A., Mika J.
    Academic press:
    Eur. J. Pharmacol. (rok: 2020, tom: 880, strony: 173166 (1-10)), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173166 - link to the publication
  15. Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia.
    Authors:
    Kwiatkowski K, Popiolek-Barczyk K, Piotrowska A, Rojewska E, Ciapała K, Makuch W, Mika J.
    Academic press:
    Cytokine (rok: 2019, tom: 16, strony: 202-213), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cyto.2019.03.007 - link to the publication
  16. Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors.
    Authors:
    Jurga AM., Rojewska E., Makuch W., Mika J.
    Academic press:
    Pharmaceutical Biology (rok: 2018, tom: 56 (1), strony: 275-286), Wydawca: Taylor&Francis Group
    Status:
    Published
    DOI:
    10.1080/13880209.2018.1457061 - link to the publication
  17. Spinal CCL1/CCR8 signaling interplay as a potential therapeutic target – evidence from a mouse diabetic neuropathy model
    Authors:
    Zychowska M., Rojewska E., Piotrowska A., Kreiner G., Nalepa I., Mika J.
    Academic press:
    International Immunopharmacology (rok: 2017, tom: 52, strony: 261–271), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.intimp.2017.09.021 - link to the publication
  18. Bidirectional action of cenicriviroc, a CCR2/CCR5 antagonist, results in alleviation of pain-related behaviors and potentiation of opioid analgesia in rats with peripheral neuropathy.
    Authors:
    Kwiatkowski K., Pawlik K., Ciapała K., Piotrowska A., Makuch W., Mika J.
    Academic press:
    Front. Immunol. (rok: 2020, tom: 11, strony: 615327(1-16)), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.615327 - link to the publication
  19. Ból neuropatyczny: etiologia, patomechanizm, implikacje kliniczne wynikające z badań podstawowych
    Authors:
    Kwiatkowski K., Mika J.
    Academic press:
    Problemy Edukacji, Rehabilitacji i Socjalizacji Osób Niepełnosprawnych (rok: 2017, tom: 25(2/2017), strony: 113-125), Wydawca: Wydawnictwo Uniwersytetu Śląskiego, Katowice
    Status:
    Published
    DOI:
    - - link to the publication
  20. CCR4 antagonist (C021) administration diminishes hypersensitivity and enhances the analgesic potency of morphine and buprenorphine in mouse model of neuropathic pain
    Authors:
    Bogacka J., Ciapala K., Pawlik K., Kwiatkowski K., Dobrogowski J., Przeklasa-Muszyńska A., Mika J.
    Academic press:
    Front. Immunol. (rok: 2020, tom: 11, strony: 1241(1-17)), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.01241 - link to the publication
  21. Metamizol relieves pain by influencing the cytokine levels in the dorsal root ganglia in a rat model of neuropathic pain
    Authors:
    Zajaczkowska R., Kwiatkowski K., Pawlik K., Piotrowska A., Rojewska E., Makuch W., Wordliczek J., Mika J.
    Academic press:
    Pharmacol. Rep. (rok: 2020, tom: 72(5), strony: 1310-1322), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1007/s43440-020-00137-8 - link to the publication
  22. Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury
    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kreiner G., Ciechanowska A., Makuch W., Nalepa I, Mika J.
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 10, strony: 45313), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.02198 - link to the publication
  23. The importance of chemokines in neuropathic pain development and opioid analgesic potency
    Authors:
    Kwiatkowski K., Mika J.
    Academic press:
    Pharmacological Reports (rok: 2018, tom: 70, strony: 821-30), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.01.006 - link to the publication
  1. A new antagonists of H3R as a potential neuropathic painkillers
    Authors:
    Popiolek-Barczyk K., Łazewska D., Latacz G., Olejarz A., Stark H., Makuch W., Kieć-Kononowicz K., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research "From Lab to clinic" (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 22-27.06.
    Status:
    Published
  2. Alterations in CCL2, CCL7 and CCL12 expression – studies in the model of Traumatic Brain Injury and glial cell cultures.
    Authors:
    Popiolek-Barczyk K., Ciechanowska A., Oggioni M., Mercurio D., Ippati S., Piotrowska A. Kwiatkowski K., De Simoni Mg., Mika J.
    Conference:
    European Meeting on Glial Cells in Health and Disease (rok: 2019, ), Wydawca: Wiley Online Library
    Data:
    konferencja 10-13.07.
    Status:
    Published
  3. Antinociceptive effects of novel histamine H3R receptor antagonist in mouse model of neuropathic pain
    Authors:
    Popiołek Barczyk K., Łażewska D., Latacz G., Makuch W., Rojewska E., Kieć-Kononowicz K., Mika J
    Conference:
    Neurochemical Conference Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches" (rok: 2017, ), Wydawca: Warszawa IMDIK PAN
    Data:
    konferencja 19-20.10.2017
    Status:
    Published
  4. Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain.
    Authors:
    Pawlik K., Piotrowska A., Rojewska E., Ciechanowska A., Makuch W., Mika J.
    Conference:
    3rd Central European Biomedical Congress (rok: 2018, ), Wydawca: CEBC, Krakow 2018
    Data:
    konferencja 15-18.09.2018 Krakow
    Status:
    Published
  5. Pharmacological kynurenine 3-monooxygenase enzyme Inhibition by UPF-648 significantly reduces neuropathic pain and enhanced opioid analgesia in a rat model.
    Authors:
    Ciapała K., Rojewska E., Piotrowska A., Pawlik K., Makuch W., Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (rok: 2019, ), Wydawca: EHRS
    Data:
    konferencja 15-18.05
    Status:
    Published
  6. Significance of CCL17/CCL22/CCL2 signalling in nociceptive transmission and morphine analgesic potency
    Authors:
    Bogacka J., Ciapała K., Pawlik K., Kwiatkowski K., Dobrogowski J., Przeklasa-Muszynska A., Mika J.
    Conference:
    4th Central European Biomedical Congress "The impact of bioinformatics and omics on biology and medicine" (rok: 2021, ), Wydawca: IF PAN Kraków
    Data:
    konferencja 7-9.06.2021
    Status:
    Published
  7. The (±)-NBI-74330 (CXCR3 antagonist) reduces neuropathic pain and influences the level of nociceptive factors – evidence from in vivo and in vitro studies
    Authors:
    Pawlik K., Piotrowska A., Rojewska E., Popiołek- Barczyk K., Mika J.
    Conference:
    Neuronus 2018 (rok: 2018, ), Wydawca: Neuronus IBRO NEUROSCIENCE FORUM
    Data:
    konferencja 20-22.04.2018 Krakow
    Status:
    Published
  8. The importance of C021 (CCR4 antagonist) in the development of pain-related behavior and opioid-induced analgesia.
    Authors:
    Bogacka J., Ciapała K., Pawlik K., Kwiatkowski K., Dobrogowski J., Przeklasa-Muszynska A., Mika J.
    Conference:
    Neuronus IBRO NEUROSCIENCE FORUM (rok: 2020, ), Wydawca: IBRO
    Data:
    konferencja 8-11.12.2020
    Status:
    Published
  9. The importance of spinal CC chemokine ligands 2 and 7 in neuropathic pain development and opioids effectiveness
    Authors:
    Kwiatkowski K., Popiołek- Barczyk K., Rojewska E., Piotrowska A., Mika J.
    Conference:
    31st ENCP Congress (rok: 2018, ), Wydawca: ENCP
    Data:
    konferencja 6-9.10.2018 Barcelona, Hiszpania
    Status:
    Published
  10. Wpływ modulatorów szlaków wewnątrzkomórkowych - peiminy i fisetyny - na nocycepcję oraz efektywność opioidów w mysim modelu bólu neuropatycznego
    Authors:
    Ciapała K, Rojewska E, Pawlik K, Mika J
    Conference:
    XXXIX SZKOŁA ZIMOWA Instytutu Farmakologii im. Jerzego Maja PAN "Dysfunkcje metaboliczne a choroby ośrodkowego układu nerwowego" (rok: 2022, ), Wydawca: IF PAN
    Data:
    konferencja 2-4.03.2022, Kraków
    Status:
    Published
  11. Antagoniści receptorów chemokinowych jako modulatory komórek glejowych w bólu neuropatycznym.
    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kwiatkowski K., Ciechanowska A., Makuch W., Mika J.
    Conference:
    VII SYMPOZJUM "POSTĘPY W LECZENIU BÓLU" (rok: 2018, ), Wydawca: INDEX COPERNICUS
    Data:
    konferencja 4-6.10.2018 Zakopane
    Status:
    Published
  12. Blockade of CXCR3 by (±)-NBI-74330 inhibits neuropathic pain in rats by modulating release of CXCR3 ligands.
    Authors:
    Piotrowska A, Rojewska E, Zychowska M., Makuch W., Mika J.
    Conference:
    Neuronus 2018 (rok: 2018, ), Wydawca: Neuronus IBRO NEUROSCIENCE FORUM
    Data:
    konferencja 20-22.04.2018 Krakow
    Status:
    Published
  13. Comparison of antinociceptive effects of CXCR2 and CXCR3 receptor antagonists and their influence on opioids analgesia of neuropathic pain model.
    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Ciechanowska A., Makuch W., Mika J.
    Conference:
    Pain in Europe XI, 11th Congress of the European Pain Federation EFIC, Walencja, Hiszpania (rok: 2019, ), Wydawca: EFIC
    Data:
    konferencja 4-7.09
    Status:
    Published
  14. Fisetin, a plant-derived flavonoid as a new promising tool in neuropathic pain management – evidences from behavioral studies in mice
    Authors:
    Ciapała K., Rojewska E., Mika J.
    Conference:
    4th Central European Biomedical Congress "The impact of bioinformatics and omics on biology and medicine" (rok: 2021, ), Wydawca: IF PAN, Kraków
    Data:
    konferencja 7-9.06.2021
    Status:
    Published
  15. Involvement of chemokines CCL2 and CCL7 in pathogenesis of neuropathic pain in mice.
    Authors:
    Kwiatkowski K., Popiolek-Barczyk K., Rojewska E., Makuch W., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research "From Lab to clinic" (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 22-27.06.
    Status:
    Published
  16. Pharmacological modulation of glia attenuate neuropathic pain and enhance opioid effectiveness
    Authors:
    Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (rok: 2019, ), Wydawca: EHRS
    Data:
    konferencja 15-18.05
    Status:
    Published
  17. Plerixafor osłabia rozwój bólu neuropatycznego u szczurów poprzez modulację endogennych czynników pronocyceptywnych
    Authors:
    Kwiatkowski K., Rojewska E., Piotrowska A., Makuch W., Mika J.
    Conference:
    Europejska Szkoła Bólu w Krakowie (rok: 2017, ), Wydawca: Index Copernicus
    Data:
    konferencja 25-29.06.2017
    Status:
    Published
  18. The dual CCR2/CCR5 antagonist, Cenicriviroc, attenuated neuropathic pain-related behavior and enhanced morphine effectiveness.
    Authors:
    Ciapała K., Kwiatkowski K., Makuch W., Mika J.
    Conference:
    Pain in Europe XI, 11th Congress of the European Pain Federation EFIC, Walencja, Hiszpania (rok: 2019, ), Wydawca: EFIC
    Data:
    konferencja 4-7.09.
    Status:
    Published
  19. Wpływ XCL1 na rozwój symptomów bólu neuropatycznego u myszy
    Authors:
    Ciechanowska A, Rojewska E, Piotrowska-Murzyn A, Pawlik K, Ciapała K, Mika J.
    Conference:
    XXXIX SZKOŁA ZIMOWA Instytutu Farmakologii im. Jerzego Maja PAN "Dysfunkcje metaboliczne a choroby ośrodkowego układu nerwowego" (rok: 2022, ), Wydawca: IF PAN
    Data:
    konferencja 2-4.03.2022, Kraków
    Status:
    Published
  20. Antinociceptive effects of pharmacological kynurenine-3-monooxygenase inhibition by UPF-648 and its influence on opioids effectiveness in neuropathic rats
    Authors:
    Ciapala K., Rojewska E., Piotrowska A., Pawlik K., Makuch W., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research "From Lab to clinic" (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 22-27.06.
    Status:
    Published
  21. CCR1 and CCR3 antagonism brings beneficial effects in neuropathic pain by affecting microglia and neutrophils
    Authors:
    Pawlik K., Ciechanowska A., Makuch W., Mika J.
    Conference:
    4th Central European Biomedical Congress "The impact of bioinformatics and omics on biology and medicine" (rok: 2021, ), Wydawca: IF PAN Kraków
    Data:
    konferencja 7-9.06.2021
    Status:
    Published
  22. CXCR3 receptor as new target to treat neuropathic pain: efficacy of a receptor antagonist in in vitro and in vivo studies.
    Authors:
    Piotrowska A., Kwiatkowski K., Rojewska E., Pawlik K., Ciechanowska A., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research "From Lab to clinic" (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 22-27.06.
    Status:
    Published
  23. Czy leki antyretrowirusowe mogą działać przeciwbólowo? Rola CCR5 w bólu neuropatycznym.
    Authors:
    Kwiatkowski K., Ciapała K., Popiolek-Barczyk K., Piotrowska A., Makuch W., Mika J.
    Conference:
    X Zjazd Polskiego Towarzystwa Badania Bólu – MEDYCYNA BÓLU 2019 (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 26-28-09.
    Status:
    Published
  24. Direct and Indirect Pharmacomodulation of CC Chemokine Receptor 2 Activity Results in Neuropathic Pain Attenuation and Enhancement of Opioids-Induced Analgesia in Rodents
    Authors:
    Kwiatkowski K., Popiolek-Barczyk K., Piotrowska A., Rojewska E., Makuch W., Mika J.
    Conference:
    7th International Congress on Neuropathic Pain (NeuPSIG 2019) (rok: 2019, ), Wydawca: NeuPSIG
    Data:
    konferencja 9-11.05.
    Status:
    Published
  25. Importance of CCL17/CCL22/CCR4 signaling in nociceptive transmission and morphine analgesic potency in naïve and neuropathic animals
    Authors:
    Kujacz J., Popiołek-Barczyk K., Makuch W., Ciechanowska A., Dobrogowski J., Przeklasa-Muszynska A., J Mika J.
    Conference:
    Pain in Europe XI, 11th Congress of the European Pain Federation EFIC, Walencja, Hiszpania (rok: 2019, ), Wydawca: EFIC
    Data:
    konferencja 4-7.09.
    Status:
    Published
  26. Pharmacological blockade of CCR1 and CCR5 diminished neuropathic pain and enhanced morphine/buprenorphine effectiveness.
    Authors:
    Pawlik K., Piotrowska A., Kwiatkowski K., Ciapała K., Makuch W., Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (rok: 2019, ), Wydawca: EHRS
    Data:
    konferencja 15-18.05
    Status:
    Published
  27. Wpływ farmakologicznej modulacji receptora histaminowego H3 na proces nocycepcji w bólu neuropatycznym.
    Authors:
    Popiołek-Barczyk K., Łażewska D., Ciechanowska A., Makuch W., Kieć- Kononowicz K., Mika J.
    Conference:
    VII SYMPOZJUM "POSTĘPY W LECZENIU BÓLU" (rok: 2018, ), Wydawca: INDEX COPERNICUS
    Data:
    konferencja 4-6.10.2018 Zakopane
    Status:
    Published
  28. Comparison of analgesic effects of maraviroc, RS504393 and cenicriviroc in rodents after sciatic nerve injury based on behavioral and molecular studies.
    Authors:
    Kwiatkowski K., Ciapała K., Popiołek-Barczyk K., Makuch W., Mika J.
    Conference:
    Pain in Europe XI, 11th Congress of the European Pain Federation EFIC, Walencja, Hiszpania (rok: 2019, ), Wydawca: EFIC
    Data:
    konferencja 4-7.09
    Status:
    Published
  29. Modulacja CCR1 i CCR3 obniża symptomy bólu neuropatycznego poprzez wpływ na aktywację mikrogleju i neutrofili
    Authors:
    Pawlik-Szczerba K, Ciechanowska A, Makuch W, Mika J.
    Conference:
    XXXIX SZKOŁA ZIMOWA Instytutu Farmakologii im. Jerzego Maja PAN "Dysfunkcje metaboliczne a choroby ośrodkowego układu nerwowego" (rok: 2022, ), Wydawca: IF PAN
    Data:
    konferencja 2-4.03.2022, Kraków
    Status:
    Published
  30. Molecular patterns of XCL1 and its receptors after central and peripheral nervous system damages
    Authors:
    Ciechanowska A., Pawlik K., Ciapała K., Oggioni M., Mercurio D., De Simoni M.G., Mika J.
    Conference:
    4th Central European Biomedical Congress "The impact of bioinformatics and omics on biology and medicine" (rok: 2021, ), Wydawca: IF PAN Kraków
    Data:
    konferencja 7-9.06.2021
    Status:
    Published
  31. Parthenolide attenuates neuropathic pain symptoms and enhances morphine analgesia in animal model of neuropathy.
    Authors:
    Ciechanowska A., Popiołek-Barczyk K, Ciapała K., Makuch W., Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (rok: 2019, ), Wydawca: EHRS
    Data:
    konferencja 15-18.05
    Status:
    Published
  32. The antagonist of CCR4 antagonist (C021) influence level of spinal nociceptive factors and enhances morphine analgesic potency in a rat neuropathic pain
    Authors:
    Kujacz J., Popiołek-Barczyk K., Makuch W., Ciechanowska A., Rojewska E., Dobrogowski J., Przeklasa-Muszynska A., Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (rok: 2019, ), Wydawca: EHRS
    Data:
    konferencja 15-18.05
    Status:
    Published
  33. Antagonism of histamine H3 receptor reduced neuropathic pain in mice and enhanced morphine analgesia.
    Authors:
    Popiolek-Barczyk K, Łażewska D, Latacz G, Olejarz A, Makuch W., Piotrowska A., Kieć- Kononowicz K., Mika JW., Mika J.
    Conference:
    3rd Central European Biomedical Congress (rok: 2018, ), Wydawca: CEBC, Kraków 2018
    Data:
    konferencja 15-18.09.2018
    Status:
    Published
  34. Antinociceptive effects of a novel histamine H3 receptor antagonists In mouse model of neuropathic pain.
    Authors:
    K. Popiolek-Barczyk , D. Łażewska, G. Latacz, A. Olejarz, H. Stark, W. Makuch, K. Kieć-Kononowicz, J. Mika.
    Conference:
    48th meeting of the European Histamine Research Society (rok: 2019, ), Wydawca: EHRS
    Data:
    konferencja 15-18.05
    Status:
    Published
  35. Antinociceptive effects of novel histamine H3R receptor antagonist, E-162, and its influence on morphine analgesia of neuropathic pain in the mouse.
    Authors:
    Popiołek-Barczyk K., Łażewska D., Latacz G., Makuch W., Piotrowska A., Kieć-Kononowicz K., Mika J.
    Conference:
    Neuronus 2018 (rok: 2018, ), Wydawca: Neuronus IBRO NEUROSCIENCE FORUM
    Data:
    konferencja 20-22.04.2018 Krakow
    Status:
    Published
  36. Blockade of CCR4 receptor diminishes the level of nociceptive factors and potentiates morphine analgesia in a rat model of neuropathic pain.
    Authors:
    Kujacz J., Popiolek-Barczyk K., Makuch W., Ciechanowska A., Rojewska E., Dobrogowski J., Przeklasa-Muszyńska A., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research "From Lab to clinic" (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 22-27.06.
    Status:
    Published
  37. Blockade of CXCR2 inhibits neuropathic pain – related behavior and modulates primary microglial and astroglia culture.
    Authors:
    Pawlik K., Piotrowska A., Rojewska E., Ciechanowska A., Makuch W., Mika J.
    Conference:
    European Meeting on Glial Cells in Health and Disease (rok: 2019, ), Wydawca: Wiley Online Library
    Data:
    konferencja 10-13.07
    Status:
    Published
  38. Comparison of pharmacological modulation of glial cells by the CCR5 and CXCR3 receptor antagonists –in vivo and in vitro studies.
    Authors:
    Piotrowska-Murzyn A., Kwiatkowski K., Rojewska E., Pawlik K., Ciechanowska A., Mika J.
    Conference:
    European Meeting on Glial Cells in Health and Disease (rok: 2019, ), Wydawca: Wiley Online Library
    Data:
    konferencja 10-13.07
    Status:
    Published
  39. Effect of botulinum toxin type A and minocycline on lipopolysaccharide-stimulated rat microglial and astroglial cultures
    Authors:
    Piotrowska-Murzyn A., Popiołek Barczyk K., Pavone F., Mika J.
    Conference:
    XII European Meeting on Glial Cells in Health and Disease (rok: 2017, ), Wydawca: GLIA
    Data:
    konferencja 08-11.07.2017
    Status:
    Published
  40. J113863 and maraviroc reduce neuropathic pain and enhance opioid effectiveness.
    Authors:
    Pawlik K., Piotrowska A., Kwiatkowski K. Ciapala K., Makuch W., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research "From Lab to clinic" (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 22-27-.06.
    Status:
    Published
  41. Parthenolide, an inhibitor of NF-kB pathway, has analgesic properties in rodent model of neuropathic pain.
    Authors:
    Ciechanowska A., Popiolek-Barczyk K., Ciapala K., Makuch W., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research "From Lab to clinic" (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 22-27.06.
    Status:
    Published
  42. The role of selected endogenous ligands of CCR2 in neuropathic pain-related behaviors in mice.
    Authors:
    Kwiatkowski K., Popiołek- Barczyk K., Rojewska E., Żychowska M., Mika J.
    Conference:
    Neuronus 2018 (rok: 2018, ), Wydawca: Neuronus IBRO NEUROSCIENCE FORUM
    Data:
    konferencja 20-22.04.2018 Krakow
    Status:
    Published

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