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Search for new targets for an effective therapy of neuropathic pain and enhancement of opioids effects basing on the examination and modulation of changes in chemokine systems.

2016/21/B/NZ4/00128

Keywords

Descriptors

  • NZ4_4: Patofizjologia ogólna
  • NZ4_7: Neurofizjologia
  • NZ4_12: Inne zagadnienia pokrewne

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Instytut Farmakologii PAN

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Joanna Gabriela Mika

Number of co-investigators in the project: 6

Call

OPUS 11 – announced on 2016-03-15

Amount awarded
1 307 830 PLN
Project start date
2017-02-13
Project end date
2022-02-12
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Automatyczny wielodetekcyjny czytnik SPARK M10 firmy TECAN Austria. Cost: 158 118 PLN
  2. Inkubator do hodowli komórkowych.
  3. Mikroscop odwrócony.

Information in the final report

Publication in academic press/journals (23)

  1. Dataset of (±)-NBI-74330 (CXCR3 antagonist) influence on chemokines under neuropathic pain

    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kreiner G., Ciechanowska A., Makuch W., Mika J.
    Academic press:
    Data in Brief (year: 2018, volume: 21, pages: 1145–1150), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dib.2018.10.091 – link to the publication

  2. Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies.

    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kreiner G., Ciechanowska A., Makuch W., Zychowska M, Mika J.
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (year: 2018, volume: 1864, pages: 3418-3437), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2018.07.032 – link to the publication

  3. The importance of chemokines in neuropathic pain development and opioid analgesic potency

    Authors:
    Kwiatkowski K., Mika J.
    Academic press:
    Pharmacological Reports (year: 2018, volume: 70, pages: 821-30), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.01.006 – link to the publication

  4. Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model.

    Authors:
    Rojewska E, Ciapała K, Mika J.
    Academic press:
    Pharmacol Rep. (year: 2019, volume: 71(1), pages: 139-148), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.10.002 – link to the publication

  5. Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors.

    Authors:
    Jurga AM., Rojewska E., Makuch W., Mika J.
    Academic press:
    Pharmaceutical Biology (year: 2018, volume: 56 (1), pages: 275-286), Publisher: Taylor&Francis Group
    Status:
    Published
    DOI:
    10.1080/13880209.2018.1457061 – link to the publication

  6. Involvement of microglial cells in the antinociceptive effects of metamizol in a mouse model of neuropathic pain

    Authors:
    Zajaczkowska R., Popiolek- Barczyk K., Pilat D., Rojewska E., Makuch W., Wordliczek J., Mika J.
    Academic press:
    Pharmacology Biochemistry and Behavior (year: 2018, volume: 175, pages: 77-78), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pbb.2018.09.008 – link to the publication

  7. Ból neuropatyczny: etiologia, patomechanizm, implikacje kliniczne wynikające z badań podstawowych

    Authors:
    Kwiatkowski K., Mika J.
    Academic press:
    Problemy Edukacji, Rehabilitacji i Socjalizacji Osób Niepełnosprawnych (year: 2017, volume: 25(2/2017), pages: 113-125), Publisher: Wydawnictwo Uniwersytetu Śląskiego, Katowice
    Status:
    Published

  8. Comparison of the expression changes after Botulinum toxin type A and minocycline administration in lipopolysaccharide-stimulated rat microglial and astroglial cultures

    Authors:
    Piotrowska A., Popiolek-Barczyk K., Pavone F., Mika J
    Academic press:
    Frontiers in Cellular and Infection Microbiology (year: 2017, volume: 7, pages: 46039), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcimb.2017.00141 – link to the publication

  9. The RS504393 influences the level of nociceptive factors and enhances opioid analgesic potency in neuropathic rats

    Authors:
    Kwiatkowski K., Piotrowska A., Rojewska E., Makuch W., Mika J.
    Academic press:
    J Neuroimmune Pharmacol (year: 2017, volume: 12, pages: 402-419), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11481-017-9729-6 – link to the publication

  10. Tapentadol – A representative of a new class of MOR-NRI analgesics

    Authors:
    Zajaczkowska R., Przewlocka B., Kocot- Kępska M., Mika J., Leppert W., Wordliczek J.
    Academic press:
    Pharmacological Reports (year: 2018, volume: 70, pages: 812-820), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.01.005 – link to the publication

  11. Involvement of macrophage inflammatory protein-1 (MIP-1) family members in the development of diabetic neuropathy and their contribution to effectiveness of morphine

    Authors:
    Rojewska E., Zychowska M., Piotrowska A., Kreiner G., Nalepa I., Mika J.
    Academic press:
    Frontiers in Immunology (year: 2018, volume: 9, pages: 21), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.00494/abstract – link to the publication

  12. Spinal CCL1/CCR8 signaling interplay as a potential therapeutic target – evidence from a mouse diabetic neuropathy model

    Authors:
    Zychowska M., Rojewska E., Piotrowska A., Kreiner G., Nalepa I., Mika J.
    Academic press:
    International Immunopharmacology (year: 2017, volume: 52, pages: 261–271), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.intimp.2017.09.021 – link to the publication

  13. Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury

    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kreiner G., Ciechanowska A., Makuch W., Nalepa I, Mika J.
    Academic press:
    Frontiers in Immunology (year: 2019, volume: 10, pages: 46044), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.02198 – link to the publication

  14. Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia.

    Authors:
    Kwiatkowski K, Popiolek-Barczyk K, Piotrowska A, Rojewska E, Ciapała K, Makuch W, Mika J.
    Academic press:
    Cytokine (year: 2019, volume: 16, pages: 202-213), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cyto.2019.03.007 – link to the publication

  15. The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain

    Authors:
    Pawlik K., Piotrowska A., Kwiatkowski K., Ciapała K., Popiolek-Barczyk K., Makuch W., Mika J.
    Academic press:
    Immunology (year: 2020, volume: 159(4), pages: 413-428), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1111/imm.13172 – link to the publication

  16. Comparison of the beneficial effects of RS504393, maraviroc and cenicriviroc on neuropathic pain-related symptoms in rodents: behavioral and biochemical analyses

    Authors:
    Kwiatkowski K. Ciapała K., Rojewska E., Makuch W., Mika J.
    Academic press:
    Int Immunopharmacol. (year: 2020, volume: 84, pages: 106540 (1-12)), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.intimp.2020.106540 – link to the publication

  17. CCR4 antagonist (C021) administration diminishes hypersensitivity and enhances the analgesic potency of morphine and buprenorphine in mouse model of neuropathic pain

    Authors:
    Bogacka J., Ciapala K., Pawlik K., Kwiatkowski K., Dobrogowski J., Przeklasa-Muszyńska A., Mika J.
    Academic press:
    Front. Immunol. (year: 2020, volume: 11, pages: 1241(1-17)), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.01241 – link to the publication

  18. CCR4 antagonist (C021) influences the level of nociceptive factors and enhances the analgesic potency of morphine in a rat model of neuropathic pain.

    Authors:
    Bogacka J., Popiolek-Barczyk K., Pawlik K., Ciechanowska A., Makuch W., Rojewska E., Dobrogowski J., Przeklasa-Muszynska A., Mika J.
    Academic press:
    Eur. J. Pharmacol. (year: 2020, volume: 880, pages: 173166 (1-10)), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2020.173166 – link to the publication

  19. Metamizol relieves pain by influencing the cytokine levels in the dorsal root ganglia in a rat model of neuropathic pain

    Authors:
    Zajaczkowska R., Kwiatkowski K., Pawlik K., Piotrowska A., Rojewska E., Makuch W., Wordliczek J., Mika J.
    Academic press:
    Pharmacol. Rep. (year: 2020, volume: 72(5), pages: 1310-1322), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1007/s43440-020-00137-8 – link to the publication

  20. Comparison of the effects of chemokine receptors CXCR2 and CXCR3. Pharmacological modulation in neuropathic pain model – in vivo and in vitro study

    Authors:
    Piotrowska A., Ciapała K., Pawlik K., Kwiatkowski K., Rojewska E., Mika J.
    Academic press:
    Int J Mol Sci. (year: 2021, volume: 22, pages: 11074 (1-24)), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222011074 – link to the publication

  21. Blockade of CC chemokine receptor type 3 diminishes pain and enhances opioid analgesic potency in a model of neuropathic pain

    Authors:
    Pawlik K., Ciechanowska A., Ciapała K., Rojewska E., Makuch W., Mika J.
    Academic press:
    Front. Immunol. (year: 2021, volume: 12, pages: 781310 (1-20)), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.781310 – link to the publication

  22. Bidirectional action of cenicriviroc, a CCR2/CCR5 antagonist, results in alleviation of pain-related behaviors and potentiation of opioid analgesia in rats with peripheral neuropathy.

    Authors:
    Kwiatkowski K., Pawlik K., Ciapała K., Piotrowska A., Makuch W., Mika J.
    Academic press:
    Front. Immunol. (year: 2020, volume: 11, pages: 615327(1-16)), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.615327 – link to the publication

  23. Blockade of CCR4 diminishes hypersensitivity and enhances opioid analgesia - evidence from a mouse model of diabetic neuropathy

    Authors:
    Bogacka J., Ciapała K., Pawlik K., Dobrogowski J., Przeklasa-Muszynska A., Mika J.
    Academic press:
    Neuroscience (year: 2020, volume: 441, pages: 77-92), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2020.06.025 – link to the publication

Articles in post-conference publications (42)

  1. CXCR3 receptor as new target to treat neuropathic pain: efficacy of a receptor antagonist in in vitro and in vivo studies.

    Authors:
    Piotrowska A., Kwiatkowski K., Rojewska E., Pawlik K., Ciechanowska A., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research From Lab to clinic (year: 2019, pages: 24), Publisher: Index Copernicus International
    Date:
    conference 22-27.06.
    Status:
    Published

  2. A new antagonists of H3R as a potential neuropathic painkillers

    Authors:
    Popiolek-Barczyk K., Łazewska D., Latacz G., Olejarz A., Stark H., Makuch W., Kieć-Kononowicz K., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research From Lab to clinic (year: 2019, pages: 15), Publisher: Index Copernicus International
    Date:
    conference 22-27.06.
    Status:
    Published

  3. Significance of CCL17/CCL22/CCL2 signalling in nociceptive transmission and morphine analgesic potency

    Authors:
    Bogacka J., Ciapała K., Pawlik K., Kwiatkowski K., Dobrogowski J., Przeklasa-Muszynska A., Mika J.
    Conference:
    4th Central European Biomedical Congress The impact of bioinformatics and omics on biology and medicine (year: 2021, pages: 1, (Abstract Book, 99)), Publisher: IF PAN Kraków
    Date:
    conference 7-9.06.2021
    Status:
    Published

  4. Fisetin, a plant-derived flavonoid as a new promising tool in neuropathic pain management – evidences from behavioral studies in mice

    Authors:
    Ciapała K., Rojewska E., Mika J.
    Conference:
    4th Central European Biomedical Congress The impact of bioinformatics and omics on biology and medicine (year: 2021, pages: 1, (Abstract Book, 73)), Publisher: IF PAN, Kraków
    Date:
    conference 7-9.06.2021
    Status:
    Published

  5. Molecular patterns of XCL1 and its receptors after central and peripheral nervous system damages

    Authors:
    Ciechanowska A., Pawlik K., Ciapała K., Oggioni M., Mercurio D., De Simoni M.G., Mika J.
    Conference:
    4th Central European Biomedical Congress The impact of bioinformatics and omics on biology and medicine (year: 2021, pages: 1, (Abstract Book, 61)), Publisher: IF PAN Kraków
    Date:
    conference 7-9.06.2021
    Status:
    Published

  6. Direct and Indirect Pharmacomodulation of CC Chemokine Receptor 2 Activity Results in Neuropathic Pain Attenuation and Enhancement of Opioids-Induced Analgesia in Rodents

    Authors:
    Kwiatkowski K., Popiolek-Barczyk K., Piotrowska A., Rojewska E., Makuch W., Mika J.
    Conference:
    7th International Congress on Neuropathic Pain (NeuPSIG 2019) (year: 2019, pages: PTH 18), Publisher: NeuPSIG
    Date:
    conference 9-11.05.
    Status:
    Published

  7. Czy leki antyretrowirusowe mogą działać przeciwbólowo? Rola CCR5 w bólu neuropatycznym.

    Authors:
    Kwiatkowski K., Ciapała K., Popiolek-Barczyk K., Piotrowska A., Makuch W., Mika J.
    Conference:
    X Zjazd Polskiego Towarzystwa Badania Bólu – MEDYCYNA BÓLU 2019 (year: 2019, pages: 63), Publisher: Index Copernicus International
    Date:
    conference 26-28-09.
    Status:
    Published

  8. The importance of C021 (CCR4 antagonist) in the development of pain-related behavior and opioid-induced analgesia.

    Authors:
    Bogacka J., Ciapała K., Pawlik K., Kwiatkowski K., Dobrogowski J., Przeklasa-Muszynska A., Mika J.
    Conference:
    Neuronus IBRO NEUROSCIENCE FORUM (year: 2020, pages: BIO-P112), Publisher: IBRO
    Date:
    conference 8-11.12.2020
    Status:
    Published

  9. Wpływ modulatorów szlaków wewnątrzkomórkowych - peiminy i fisetyny - na nocycepcję oraz efektywność opioidów w mysim modelu bólu neuropatycznego

    Authors:
    Ciapała K, Rojewska E, Pawlik K, Mika J
    Conference:
    XXXIX SZKOŁA ZIMOWA Instytutu Farmakologii im. Jerzego Maja PAN Dysfunkcje metaboliczne a choroby ośrodkowego układu nerwowego (year: 2022, pages: 1, (abstrakt dostępny dla uczestników konferencji)), Publisher: IF PAN
    Date:
    conference 2-4.03.2022, Kraków
    Status:
    Published

  10. CCR1 and CCR3 antagonism brings beneficial effects in neuropathic pain by affecting microglia and neutrophils

    Authors:
    Pawlik K., Ciechanowska A., Makuch W., Mika J.
    Conference:
    4th Central European Biomedical Congress The impact of bioinformatics and omics on biology and medicine (year: 2021, pages: 1, (Abstract Book, 82)), Publisher: IF PAN Kraków
    Date:
    conference 7-9.06.2021
    Status:
    Published

  11. Modulacja CCR1 i CCR3 obniża symptomy bólu neuropatycznego poprzez wpływ na aktywację mikrogleju i neutrofili

    Authors:
    Pawlik-Szczerba K, Ciechanowska A, Makuch W, Mika J.
    Conference:
    XXXIX SZKOŁA ZIMOWA Instytutu Farmakologii im. Jerzego Maja PAN Dysfunkcje metaboliczne a choroby ośrodkowego układu nerwowego (year: 2022, pages: 1, (abstrakt dostępny dla uczestników konferencji)), Publisher: IF PAN
    Date:
    conference 2-4.03.2022, Kraków
    Status:
    Published

  12. Wpływ XCL1 na rozwój symptomów bólu neuropatycznego u myszy

    Authors:
    Ciechanowska A, Rojewska E, Piotrowska-Murzyn A, Pawlik K, Ciapała K, Mika J.
    Conference:
    XXXIX SZKOŁA ZIMOWA Instytutu Farmakologii im. Jerzego Maja PAN Dysfunkcje metaboliczne a choroby ośrodkowego układu nerwowego (year: 2022, pages: 1, (abstrakt dostępny dla uczestników konferencji)), Publisher: IF PAN
    Date:
    conference 2-4.03.2022, Kraków
    Status:
    Published

  13. The importance of spinal CC chemokine ligands 2 and 7 in neuropathic pain development and opioids effectiveness

    Authors:
    Kwiatkowski K., Popiołek- Barczyk K., Rojewska E., Piotrowska A., Mika J.
    Conference:
    31st ENCP Congress (year: 2018, pages: 1), Publisher: ENCP
    Date:
    conference 6-9.10.2018 Barcelona, Hiszpania
    Status:
    Published

  14. Antagonism of histamine H3 receptor reduced neuropathic pain in mice and enhanced morphine analgesia.

    Authors:
    Popiolek-Barczyk K, Łażewska D, Latacz G, Olejarz A, Makuch W., Piotrowska A., Kieć- Kononowicz K., Mika JW., Mika J.
    Conference:
    3rd Central European Biomedical Congress (year: 2018, pages: 1), Publisher: CEBC, Kraków 2018
    Date:
    conference 15-18.09.2018
    Status:
    Published

  15. Antinociceptive effects of novel histamine H3R receptor antagonist in mouse model of neuropathic pain

    Authors:
    Popiołek Barczyk K., Łażewska D., Latacz G., Makuch W., Rojewska E., Kieć-Kononowicz K., Mika J
    Conference:
    Neurochemical Conference Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches (year: 2017, pages: 1), Publisher: Warszawa IMDIK PAN
    Date:
    conference 19-20.10.2017
    Status:
    Published

  16. Plerixafor osłabia rozwój bólu neuropatycznego u szczurów poprzez modulację endogennych czynników pronocyceptywnych

    Authors:
    Kwiatkowski K., Rojewska E., Piotrowska A., Makuch W., Mika J.
    Conference:
    Europejska Szkoła Bólu w Krakowie (year: 2017, pages: 1), Publisher: Index Copernicus
    Date:
    conference 25-29.06.2017
    Status:
    Published

  17. Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain.

    Authors:
    Pawlik K., Piotrowska A., Rojewska E., Ciechanowska A., Makuch W., Mika J.
    Conference:
    3rd Central European Biomedical Congress (year: 2018, pages: 1), Publisher: CEBC, Krakow 2018
    Date:
    conference 15-18.09.2018 Krakow
    Status:
    Published

  18. Antinociceptive effects of novel histamine H3R receptor antagonist, E-162, and its influence on morphine analgesia of neuropathic pain in the mouse.

    Authors:
    Popiołek-Barczyk K., Łażewska D., Latacz G., Makuch W., Piotrowska A., Kieć-Kononowicz K., Mika J.
    Conference:
    Neuronus 2018 (year: 2018, pages: 1), Publisher: Neuronus IBRO NEUROSCIENCE FORUM
    Date:
    conference 20-22.04.2018 Krakow
    Status:
    Published

  19. The role of selected endogenous ligands of CCR2 in neuropathic pain-related behaviors in mice.

    Authors:
    Kwiatkowski K., Popiołek- Barczyk K., Rojewska E., Żychowska M., Mika J.
    Conference:
    Neuronus 2018 (year: 2018, pages: 1), Publisher: Neuronus IBRO NEUROSCIENCE FORUM
    Date:
    conference 20-22.04.2018 Krakow
    Status:
    Published

  20. Blockade of CXCR3 by (±)-NBI-74330 inhibits neuropathic pain in rats by modulating release of CXCR3 ligands.

    Authors:
    Piotrowska A, Rojewska E, Zychowska M., Makuch W., Mika J.
    Conference:
    Neuronus 2018 (year: 2018, pages: 1), Publisher: Neuronus IBRO NEUROSCIENCE FORUM
    Date:
    conference 20-22.04.2018 Krakow
    Status:
    Published

  21. The (±)-NBI-74330 (CXCR3 antagonist) reduces neuropathic pain and influences the level of nociceptive factors – evidence from in vivo and in vitro studies

    Authors:
    Pawlik K., Piotrowska A., Rojewska E., Popiołek- Barczyk K., Mika J.
    Conference:
    Neuronus 2018 (year: 2018, pages: 1), Publisher: Neuronus IBRO NEUROSCIENCE FORUM
    Date:
    conference 20-22.04.2018 Krakow
    Status:
    Published

  22. Effect of botulinum toxin type A and minocycline on lipopolysaccharide-stimulated rat microglial and astroglial cultures

    Authors:
    Piotrowska-Murzyn A., Popiołek Barczyk K., Pavone F., Mika J.
    Conference:
    XII European Meeting on Glial Cells in Health and Disease (year: 2017, pages: 1), Publisher: GLIA
    Date:
    conference 08-11.07.2017
    Status:
    Published

  23. Antagoniści receptorów chemokinowych jako modulatory komórek glejowych w bólu neuropatycznym.

    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Kwiatkowski K., Ciechanowska A., Makuch W., Mika J.
    Conference:
    VII SYMPOZJUM POSTĘPY W LECZENIU BÓLU (year: 2018, pages: 1), Publisher: INDEX COPERNICUS
    Date:
    conference 4-6.10.2018 Zakopane
    Status:
    Published

  24. Comparison of pharmacological modulation of glial cells by the CCR5 and CXCR3 receptor antagonists –in vivo and in vitro studies.

    Authors:
    Piotrowska-Murzyn A., Kwiatkowski K., Rojewska E., Pawlik K., Ciechanowska A., Mika J.
    Conference:
    European Meeting on Glial Cells in Health and Disease (year: 2019, pages: 129), Publisher: Wiley Online Library
    Date:
    conference 10-13.07
    Status:
    Published

  25. Blockade of CXCR2 inhibits neuropathic pain – related behavior and modulates primary microglial and astroglia culture.

    Authors:
    Pawlik K., Piotrowska A., Rojewska E., Ciechanowska A., Makuch W., Mika J.
    Conference:
    European Meeting on Glial Cells in Health and Disease (year: 2019, pages: 130), Publisher: Wiley Online Library
    Date:
    conference 10-13.07
    Status:
    Published

  26. Comparison of analgesic effects of maraviroc, RS504393 and cenicriviroc in rodents after sciatic nerve injury based on behavioral and molecular studies.

    Authors:
    Kwiatkowski K., Ciapała K., Popiołek-Barczyk K., Makuch W., Mika J.
    Conference:
    Pain in Europe XI, 11th Congress of the European Pain Federation EFIC, Walencja, Hiszpania (year: 2019, pages: 119), Publisher: EFIC
    Date:
    conference 4-7.09
    Status:
    Published

  27. The dual CCR2/CCR5 antagonist, Cenicriviroc, attenuated neuropathic pain-related behavior and enhanced morphine effectiveness.

    Authors:
    Ciapała K., Kwiatkowski K., Makuch W., Mika J.
    Conference:
    Pain in Europe XI, 11th Congress of the European Pain Federation EFIC, Walencja, Hiszpania (year: 2019, pages: 193), Publisher: EFIC
    Date:
    conference 4-7.09.
    Status:
    Published

  28. Importance of CCL17/CCL22/CCR4 signaling in nociceptive transmission and morphine analgesic potency in naïve and neuropathic animals

    Authors:
    Kujacz J., Popiołek-Barczyk K., Makuch W., Ciechanowska A., Dobrogowski J., Przeklasa-Muszynska A., J Mika J.
    Conference:
    Pain in Europe XI, 11th Congress of the European Pain Federation EFIC, Walencja, Hiszpania (year: 2019, pages: 108), Publisher: EFIC
    Date:
    conference 4-7.09.
    Status:
    Published

  29. Antinociceptive effects of pharmacological kynurenine-3-monooxygenase inhibition by UPF-648 and its influence on opioids effectiveness in neuropathic rats

    Authors:
    Ciapala K., Rojewska E., Piotrowska A., Pawlik K., Makuch W., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research From Lab to clinic (year: 2019, pages: 17), Publisher: Index Copernicus International
    Date:
    conference 22-27.06.
    Status:
    Published

  30. Involvement of chemokines CCL2 and CCL7 in pathogenesis of neuropathic pain in mice.

    Authors:
    Kwiatkowski K., Popiolek-Barczyk K., Rojewska E., Makuch W., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research From Lab to clinic (year: 2019, pages: 30), Publisher: Index Copernicus International
    Date:
    conference 22-27.06.
    Status:
    Published

  31. Blockade of CCR4 receptor diminishes the level of nociceptive factors and potentiates morphine analgesia in a rat model of neuropathic pain.

    Authors:
    Kujacz J., Popiolek-Barczyk K., Makuch W., Ciechanowska A., Rojewska E., Dobrogowski J., Przeklasa-Muszyńska A., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research From Lab to clinic (year: 2019, pages: 19), Publisher: Index Copernicus International
    Date:
    conference 22-27.06.
    Status:
    Published

  32. J113863 and maraviroc reduce neuropathic pain and enhance opioid effectiveness.

    Authors:
    Pawlik K., Piotrowska A., Kwiatkowski K. Ciapala K., Makuch W., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research From Lab to clinic (year: 2019, pages: 31), Publisher: Index Copernicus International
    Date:
    conference 22-27-.06.
    Status:
    Published

  33. Alterations in CCL2, CCL7 and CCL12 expression – studies in the model of Traumatic Brain Injury and glial cell cultures.

    Authors:
    Popiolek-Barczyk K., Ciechanowska A., Oggioni M., Mercurio D., Ippati S., Piotrowska A. Kwiatkowski K., De Simoni Mg., Mika J.
    Conference:
    European Meeting on Glial Cells in Health and Disease (year: 2019, pages: 107), Publisher: Wiley Online Library
    Date:
    conference 10-13.07.
    Status:
    Published

  34. Comparison of antinociceptive effects of CXCR2 and CXCR3 receptor antagonists and their influence on opioids analgesia of neuropathic pain model.

    Authors:
    Piotrowska A., Rojewska E., Pawlik K., Ciechanowska A., Makuch W., Mika J.
    Conference:
    Pain in Europe XI, 11th Congress of the European Pain Federation EFIC, Walencja, Hiszpania (year: 2019, pages: 156), Publisher: EFIC
    Date:
    conference 4-7.09
    Status:
    Published

  35. Pharmacological kynurenine 3-monooxygenase enzyme Inhibition by UPF-648 significantly reduces neuropathic pain and enhanced opioid analgesia in a rat model.

    Authors:
    Ciapała K., Rojewska E., Piotrowska A., Pawlik K., Makuch W., Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (year: 2019, pages: 95), Publisher: EHRS
    Date:
    conference 15-18.05
    Status:
    Published

  36. Pharmacological blockade of CCR1 and CCR5 diminished neuropathic pain and enhanced morphine/buprenorphine effectiveness.

    Authors:
    Pawlik K., Piotrowska A., Kwiatkowski K., Ciapała K., Makuch W., Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (year: 2019, pages: 93), Publisher: EHRS
    Date:
    conference 15-18.05
    Status:
    Published

  37. Antinociceptive effects of a novel histamine H3 receptor antagonists In mouse model of neuropathic pain.

    Authors:
    K. Popiolek-Barczyk , D. Łażewska, G. Latacz, A. Olejarz, H. Stark, W. Makuch, K. Kieć-Kononowicz, J. Mika.
    Conference:
    48th meeting of the European Histamine Research Society (year: 2019, pages: 45), Publisher: EHRS
    Date:
    conference 15-18.05
    Status:
    Published

  38. Wpływ farmakologicznej modulacji receptora histaminowego H3 na proces nocycepcji w bólu neuropatycznym.

    Authors:
    Popiołek-Barczyk K., Łażewska D., Ciechanowska A., Makuch W., Kieć- Kononowicz K., Mika J.
    Conference:
    VII SYMPOZJUM POSTĘPY W LECZENIU BÓLU (year: 2018, pages: 1), Publisher: INDEX COPERNICUS
    Date:
    conference 4-6.10.2018 Zakopane
    Status:
    Published

  39. The antagonist of CCR4 antagonist (C021) influence level of spinal nociceptive factors and enhances morphine analgesic potency in a rat neuropathic pain

    Authors:
    Kujacz J., Popiołek-Barczyk K., Makuch W., Ciechanowska A., Rojewska E., Dobrogowski J., Przeklasa-Muszynska A., Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (year: 2019, pages: 92), Publisher: EHRS
    Date:
    conference 15-18.05
    Status:
    Published

  40. Parthenolide attenuates neuropathic pain symptoms and enhances morphine analgesia in animal model of neuropathy.

    Authors:
    Ciechanowska A., Popiołek-Barczyk K, Ciapała K., Makuch W., Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (year: 2019, pages: 95), Publisher: EHRS
    Date:
    conference 15-18.05
    Status:
    Published

  41. Parthenolide, an inhibitor of NF-kB pathway, has analgesic properties in rodent model of neuropathic pain.

    Authors:
    Ciechanowska A., Popiolek-Barczyk K., Ciapala K., Makuch W., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research From Lab to clinic (year: 2019, pages: 36), Publisher: Index Copernicus International
    Date:
    conference 22-27.06.
    Status:
    Published

  42. Pharmacological modulation of glia attenuate neuropathic pain and enhance opioid effectiveness

    Authors:
    Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (year: 2019, pages: 30), Publisher: EHRS
    Date:
    conference 15-18.05
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski