Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Activation of endogenous pronociceptive mechanisms of opioid system as an important factors in the development of neuropathic pain - mechanisms and potential targets for new therapies

2012/06/A/NZ4/00028

Keywords:

pain opioid peptides neuropathy opioid-induced hyperalgesia animal models

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ4_7: Neurophysiology
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Barbara Przewłocka 

Number of co-investigators in the project: 5

Call: MAESTRO 3 - announced on 2012-06-15

Amount awarded: 2 598 300 PLN

Project start date (Y-m-d): 2013-04-09

Project end date (Y-m-d): 2017-12-08

Project duration:: 56 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. CFX96 Touch™ Real-Time PCR Detection System (151 700 PLN)
  2. komputer Lenovo.

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (16)
  1. Bifunctional opioid/nociceptin hybrid KGNOP1 effectively attenuates pain-related behaviour in a rat model of neuropathy
    Authors:
    STARNOWSKA J., Guillemyn K., MAKUCH W., Mika J., Ballet S., PRZEWLOCKA B.
    Academic press:
    Eur J Pharm Sci. (rok: 2017, tom: 104, strony: 221-229), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejps.2017.03.029 - link to the publication
  2. Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - Neurokinin-1antagonist peptidomimetics.
    Authors:
    Guillemyn K, Kleczkowska P, Lesniak A, Dyniewicz J, Van der Poorten O, Van den Eynde I, Keresztes A, Varga E, Lai J, Porreca F, Chung NN, Lemieux C, MIKA J, ROJEWSKA E, MAKUCH W, Van Duppen J, PRZEWLOCKA B, Vanden Broeck J, Lipkowski AW, Schiller PW, Tourwé D, Ballet S.
    Academic press:
    Eur J Med Chem (rok: 2015, tom: 92, strony: 64-77), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2014.12.033 - link to the publication
  3. Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats
    Authors:
    ROJEWSKA E., MAKUCH W., PRZEWLOCKA B., MIKA J
    Academic press:
    Neuropharmacology (rok: 2014, tom: 86, strony: 301-310), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2014.08.001 - link to the publication
  4. Neuropathic Pain Dysregulates Gene Expression of the Forebrain Opioid and Dopamine Systems
    Authors:
    Wawrzczak-Bargieła A, Ziółkowska B, Piotrowska A, Starnowska-Sokół J, Rojewska E, Mika J, Przewłocki R, Przewłocka B
    Academic press:
    Neurotoxicity Research (rok: 2020, tom: -, strony: -), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    10.1007/s12640-020-00166-4 - link to the publication
  5. Alterations in the Activity of Spinal and Thalamic Opioid Systemsin a Mice Neuropathic Pain Model
    Authors:
    Rojewska E, Wawrzczak-Bargiela A, Szucs E, Benyhe S, Starnowskal J, Mika J, Przewlocki R, Przewlocka B
    Academic press:
    Neuroscience (rok: 2018, tom: 390, strony: 293-302), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuroscience.2018.08.013 - link to the publication
  6. Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice
    Authors:
    . STARNOWSKA J., Costante R., Guillemyn K., POPIOLEK-BARCZYK K., Chung N.N., Lemieux C., Keresztes A., Van Duppen J., Mollica A., Streicher J., Vanden Broeck J., Schiller P.W., Tourwé D., MIKA J., Ballet S., PRZEWLOCKA B.
    Academic press:
    ACS Chem Neurosci (rok: 2017, tom: -, strony: 45301), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acschemneuro.7b00226 - link to the publication
  7. Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.
    Authors:
    Guillemyn K, Starnowska J, Lagard C, Dyniewicz J, Rojewska E, Mika J, Chung NN, Utard V, Kosson P, Lipkowski AW, Chevillard L, Arranz-Gibert P, Teixidó M, Megarbane B, Tourwé D, Simonin F, Przewlocka B, Schiller PW, Ballet S.
    Academic press:
    J Med Chem. (rok: 2016, tom: 59, strony: 3777-92), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.5b01976 - link to the publication
  8. Delta-opioid receptor analgesia is independent of microglial activation in a rat model of neuropathic pain
    Authors:
    Mika J, Popiołek-Barczyk K, Rojewska E, Makuch W, Starowicz K, Przewłocka B.
    Academic press:
    Plos One (rok: 2014, tom: 9, strony: e104420), Wydawca: Plos
    Status:
    Published
    DOI:
    10.1371/journal.pone.0104420 - link to the publication
  9. Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.
    Authors:
    Betti C, Starnowska J, Mika J, Dyniewicz J, Frankiewicz L, Novoa A, Bochynska M, Keresztes A, Kosson P, Makuch W, Van Duppen J, Chung NN, Vanden Broeck J, Lipkowski AW, Schiller PW, Janssens F, Ceusters M, Sommen F, Meert T, Przewlocka B, Tourwé D, Ballet S.
    Academic press:
    ACS Med Chem Lett. (rok: 2015, tom: 6, strony: 1209-14), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsmedchemlett.5b00359. - link to the publication
  10. Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain
    Authors:
    Piotrowska A., Starnowska-Sokol J, Makuch W, Mika J, Witkowska E, Tymecka D., Wilenska B, Misicka A, Przewlocka B
    Academic press:
    Pain (rok: 2020, tom: -, strony: -), Wydawca: IASP
    Status:
    Submitted
    DOI:
    -braK - link to the publication
  11. Novel hybrid compounds, opioid agonist+melanocortin 4 receptor antagonist, as efficient analgesics in mouse neuropathic pain model
    Authors:
    Joanna Starnowska-Sokół, Wioletta Makuch, Anna Piotrowska, Joanna Mika, Ewa Witkowska, Magda Godlewska, Jowita Osiejuk, Sandra Gątarz, Aleksandra Misicka, Barbara Przewlocka
    Academic press:
    Neuropharmacology (rok: 2020, tom: -, strony: -), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  12. Podstawowe mechanizmy działania przeciwbólowego opioidów.
    Authors:
    PRZEWLOCKA B.
    Academic press:
    Medycyna paliatywna w praktyce. (rok: 2017, tom: 11(2), strony: 11 (2), 48-53), Wydawca: Medycyna paliatywna
    Status:
    Published
    DOI:
    brak - link to the publication
  1. The role of opioid peptides under neuropathic pain
    Authors:
    MIKA J
    Conference:
    The 12th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS" (rok: 2014, ), Wydawca: TERMEDIA Publishing House
    Data:
    konferencja 20-21.11.2014
    Status:
    Published
  2. Neurochemical changes in opioid systems activity in adult mice as consequences of neonatal painful stimulation
    Authors:
    KOSTRZEWA M., KUCHARCZYK M., STAROWICZ M., Luchetti A., d'Amato F., Pavone F., PRZEWLOCKA B
    Conference:
    NEURONUS 2014 IBRO&IRUN Neuroscience Forum (rok: 2014, ), Wydawca: nie dotyczy
    Data:
    konferencja 25-27.04.2014
    Status:
    Published
  3. The effects of novel hybrid compounds with opioid agonistic and NK1 antagonistic properties in neuropathic pain models in mice and rats
    Authors:
    Starnowska J., Mika J., Przewlocka B.
    Conference:
    Translational Pain Research "From Lab to clinic", European Pain Federation Krakow Pain School (rok: 2015, ), Wydawca: Index Copernicus
    Data:
    konferencja 5-9.07.2015, Kraków
    Status:
    Published
    DOI:
    link to the publication
  4. Wpływ modulacji czynników immunologicznych na efektywność leków opioidowych stosowanych w praktyce klinicznej.
    Authors:
    Mika J, Rojewska E, Makuch W, Żychowska M, Popiołek-Barczyk K, Przewłocka B.
    Conference:
    VII Zjazd Polskiego Towarzystwa Badania Bólu (rok: 2013, ), Wydawca: Index Copernicus
    Data:
    konferencja 25-28 września 2013, Zakopane
    Status:
    Published
  5. Can opioids work better in neuropathic pain? Novel hybrid compounds in animal study
    Authors:
    Starnowska-Sokół J, Misicka A, Guillemyn K, Mika J, Ballet S, Przewłocka B
    Conference:
    VII Sympozjum "Postępy w leczeniu bólu" (rok: 2018, ), Wydawca: Index Copernicus
    Data:
    konferencja 04-06.10.2018
    Status:
    Published
  6. Comparison of pronociceptive system's activity in two neuropathic pain models in mice.
    Authors:
    STARNOWSKA J., ROJEWSKA E., MIKA J., PRZEWLOCKA B
    Conference:
    The 12th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS" (rok: 2014, ), Wydawca: TERMEDIA Publishing House
    Data:
    konferencja 20-21.11.2014
    Status:
    Published
  7. Targeting opioid and nociceptin receptors to attenuate neuropathic pain: testing of novel bifunctional ligands
    Authors:
    Starnowska J., Guillemyn K, Rojewska E., Makuch W., Mika J., Przewlocka B., Ballet S.
    Conference:
    10 th FENS Forum Neuroscience (rok: 2016, ), Wydawca: Federation of European Neurosciences Societies (FENS)
    Data:
    konferencja 2-6.07.2016, Kopenhaga
    Status:
    Published
  8. The designed opioid agonist-NK1 antagonist hybrid as an effective analgesic in neuropathic pain
    Authors:
    MAKUCH W., MIKA J., ROJEWSKA E., STARNOWSKA J., Guillemyn K., Betti C., Ballet S., PRZEWLOCKA B
    Conference:
    NEURONUS 2014 IBRO&IRUN Neuroscience Forum (rok: 2014, ), Wydawca: nie dotyczy
    Data:
    konferencja 27.04.2014
    Status:
    Published
  9. Comparison of analgesic action of novel opioid-NK1R bifunctional ligands in acute and neuropathic pain in mice
    Authors:
    Starnowska J., Guillemyn K., Betti C., Makuch W., Ballet S., Mika J., Przewlocka B
    Conference:
    22nd Scientific Conference, Society of Neuroimmune Pharmacology (SNIP) (rok: 2016, ), Wydawca: Kraków
    Data:
    konferencja 6-9.04.2016, Kraków
    Status:
    Published
  10. The presence of mu- and kappa- but not delta- opioid receptors on microglia weakens analgesia after selective ligands in rat model of neuropathic pain
    Authors:
    MIKA J., ROJEWSKA E., POPIOLEK-BARCZYK K., MAKUCH W., STAROWICZ K., PRZEWLOCKA B
    Conference:
    7th World Congress, World Institute of Pain (rok: 2014, ), Wydawca: nie dotyczy
    Data:
    konferencja 7-10.05.2014
    Status:
    Published
  11. Analgesic effects of novel nociceptin analogues in neuropathy.
    Authors:
    Starnowska J., Mika J., Rojewska E., Makuch W., Guillemyn K., Ballet S., Przewłocka B.
    Conference:
    NEURONUS 2015, IBRO&IRUN Neuroscience Forum (rok: 2015, ), Wydawca: Neuronus, Kraków
    Data:
    konferencja 17-19.04.2015, Kraków
    Status:
    Published
    DOI:
    link to the publication
  12. Bifunctional hybrid compounds: towards improved neuropathic pain treatments.
    Authors:
    STARNOWSKA J., Guillemyn K., MAKUCH W., ROJEWSKA E., POPIOLEK-BARCZYK K., MIKA J., Ballet S., PRZEWLOCKA B.
    Conference:
    European Pain School (rok: 2017, ), Wydawca: IASP
    Data:
    konferencja 4-11.06.2017
    Status:
    Published
  13. Hybrid peptidomimetics for the use in neuropathic pain
    Authors:
    Ewa Witkowska, Jowita Osiejuk, Magda Godlewska, Sandra Gatarz, Beata Wilenska, Joanna Starnowska, Anna Piotrowska-Murzyn, Joanna Mika, Barbara Przewlocka, Aleksandra Misicka
    Conference:
    35th European Peptide Symposium (rok: 2018, ), Wydawca: European Peptide Society & PSP
    Data:
    konferencja 12.09.2028
    Status:
    Published
  14. Molekularne mechanizmy działania opioidów.
    Authors:
    Przewlocka B.
    Conference:
    VII Zjazd Polskiego Towarzystwa Badania Bólu (rok: 2013, ), Wydawca: Index Copernicus
    Data:
    konferencja 25-28 września 2013, Zakopane
    Status:
    Published
  15. Opioid agonist-neurokinin 1 antagonist designed multiple ligands alleviate both acute and neuropathic pain in rats.
    Authors:
    Starnowska J, Makuch W., Betti C, Frankiewicz Ł., Novoa A., Tourwé D., Ballet S., Mika J, Przewłocka B.
    Conference:
    Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics. Neurochemical Conference (rok: 2015, ), Wydawca: Warszawa, IMDiK PAN
    Data:
    konferencja 22-23.10.2015, Warszawa
    Status:
    Published
    DOI:
    link to the publication
  16. The activation of pro- and antinociceptive PENK-derived peptides as an important element in pathology of neuropathic pain – behavioural studies
    Authors:
    Piotrowska A, Starnowska J, Makuch W, Mika J, Przewlocka B
    Conference:
    Society on NeuroImmune Pharmacology (SNIP) (rok: 2016, ), Wydawca: SNIP
    Data:
    konferencja 6-9.04.2016
    Status:
    Published

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