Search results

1. Dual-acting 5-HT6/5-HT7 receptor antagonists: exploring beneficial effects for the treatment of neurodegenerative disord…

Principal investigator: Michał Kamiński

Uniwersytet Jagielloński

Call: PRELUDIUM 24, Panel: NZ7

2. Dual 5-HT3 receptor/5-HT6 receptor antagonists in neuropsychiatric and neurological disorders

Principal investigator: prof. Paweł Maria Zajdel

Uniwersytet Jagielloński, Collegium Medicum

Call: OPUS 22, Panel: NZ7

3. Co-crystallization and co-amorphization of angiotensin II receptor blockers leading to more soluble compounds with a bif…

Principal investigator: dr Marika Ewa Turek

Akademia im. Jana Długosza w Częstochowie

Call: PRELUDIUM 17, Panel: ST5

4. The assessment of cysteinyl leukotriene receptor antagonist role in inhibition of atherosclerosis, proliferation and its…

Principal investigator: dr hab. Paweł Maga

Uniwersytet Jagielloński, Collegium Medicum

Call: OPUS 17, Panel: NZ5

5. New vanilloid type 1 receptor (TRPV1) antagonists in the search for substances with wide-spectrum of anticonvulsant and …

Principal investigator: dr hab. Krzysztof Tomasz Kamiński

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 14, Panel: NZ7

6. Radiopharmaceuticals based on neurokinin-1 receptor antagonists for the diagnosis and therapy of a brain tumour - gliobl…

Principal investigator: prof. Aleksandra Misicka-Kęsik

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Call: OPUS 13, Panel: NZ7

7. Characterization and improvement of anti-cancer properties of second generation antagonists of Mdm2 oncoprotein

Principal investigator: dr Łukasz Skalniak

Uniwersytet Jagielloński, Wydział Chemii

Call: SONATA 11, Panel: NZ7

8. Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese…

Principal investigator: prof. Maria Wanda Bretner

Politechnika Warszawska, Wydział Chemiczny

Call: OPUS 9, Panel: ST5

9. Quantitative assessment of vascular endothelial growth factor (VEGF) in serum, follicular fluid (FF) and VEGF mRNA in gr…

Principal investigator: prof. Artur Jacek Jakimiuk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Call: OPUS 1, Panel: NZ5

10. The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

Principal investigator: Magdalena Maria Żarnik

Uniwersytet Jagielloński, Wydział Chemii

Call: PRELUDIUM 20, Panel: ST4

11. Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan…

Principal investigator: prof. Andrzej Mikołaj Pilc

Instytut Farmakologii PAN

Call: OPUS 19, Panel: NZ7

12. Evaluation of the activity of MDM2-p53 antagonist RG7388 in mouse cancer models, alone and in combination with anti-PD-1…

Principal investigator: Aneta Sylwia Nieznańska

Uniwersytet Jagielloński, Wydział Chemii

Call: PRELUDIUM 18, Panel: NZ5

13. Połączone działanie agonistów receptorów adenozynowych i antagonistów receptora P2Y12 zwiększa hamowanie funkcji płytek …

Principal investigator: Nina Małgorzata Wolska

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

Call: ETIUDA 7, Panel: NZ3

14. Prognostic value of platelet-derived microRNAs in patients with acute coronary syndrome treated with novel P2Y12 recepto…

Principal investigator: dr hab. Aleksandra Gąsecka-van der Pol

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Call: PRELUDIUM 16, Panel: NZ7

15. Development of macrocyclic peptide antagonists of the PD-1/PD-L1 pathway. Charcterization of simultaneous administration…

Principal investigator: dr Katarzyna Magiera-Mularz

Uniwersytet Jagielloński, Wydział Chemii

Call: SONATA 14, Panel: NZ7

16. Non-vitamin K antagonist oral anticoagulants (NOACs) as modulators of valvular calcification and inflammation in aortic …

Principal investigator: dr hab. Joanna Natorska

Krakowski Szpital Specjalistyczny im. Jana Pawła II

Call: OPUS 15, Panel: NZ5

17. Multifunctional ligands - TRPA1 channel antagonists and phosphodiesterases inhibitors as a new approach for the treatmen…

Principal investigator: prof. Grażyna Chłoń-Rzepa

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 15, Panel: NZ7

18. New mulitple target-directed ligands - A1/A2A adenosine receptors antagonists and monoamine oxidase B inhibitors - searc…

Principal investigator: Michał Karol Załuski

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: PRELUDIUM 12, Panel: NZ7

19. Non-quinazoline antagonists of apha1 and 5-HT2A receptors with pleiotropic effects as a new perspective for hypertension…

Principal investigator: dr Monika Kubacka

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: SONATA 8, Panel: NZ7

20. Design and synthesis of phosphoroorganic antagonists of BIR domain of apoptosis inhibitor proteins (IAP)

Principal investigator: dr Agnieszka Łupicka-Słowik

Politechnika Wrocławska, Wydział Chemiczny

Call: PRELUDIUM 7, Panel: ST5

21. Influence of antagonists (scopolamine and 3-quinuclidinyl benzilate) and agosists (carbachol) of muscarinic cholinergic …

Principal investigator: Szymon Piotr Chowański

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Call: PRELUDIUM 5, Panel: NZ9

22. Structure-activity relationship of bifunctional peptides, agonists of opioid receptors and antagonists of neurokinin rec…

Principal investigator: Jolanta Dyniewicz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Call: PRELUDIUM 2, Panel: ST5

23. Analysis of the anti-nociceptive and anti-inflammatory action of histamine H4 receptor antagonist in inflammatory nocice…

Principal investigator: Przemysław Rzodkiewicz

Instytut Reumatologii im. prof. dr hab. med. Eleonory Reicher

Call: PRELUDIUM 2, Panel: NZ4

24. Clinical efficacy of pharmacotherapy with antihistaminics and leukotriene antagonists and the therapy impact on cyclooxy…

Principal investigator: Paulina Maria Korczyńska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Call: PRELUDIUM 1, Panel: NZ5

25. Development of a method for the structure prediction of GPCRs complexes with agonists and antagonists, including the lig…

Principal investigator: dr Michał Koliński

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Call: SONATA 1, Panel: NZ2

26. Synthesis and marking the activity of new potential antagonists of receptors for excitatory amino acids which have the s…

Principal investigator: prof. Aleksander Paweł Mazurek

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Call: OPUS 1, Panel: NZ4

27. The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic …

Principal investigator: dr Katarzyna Anna Szczepańska

Instytut Farmakologii PAN

Call: OPUS 23, Panel: NZ7

28. New selective antagonists of ionotropic glutamate non-NMDA receptors

Principal investigator: dr Ewa Monika Szymańska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 8, Panel: NZ7

29. Targeting the serotonin 5-HT7 receptor in a search for new strategies of mental disorders treatment

Principal investigator: Patryk Pyka

Uniwersytet Jagielloński, Collegium Medicum

Call: PRELUDIUM 22, Panel: NZ7

30. Self-learning systems in the design of compounds modulating GPCR receptors activation.

Principal investigator: dr hab. Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Call: OPUS 20, Panel: NZ2

31. Quinoxalino-2,3-diones as potent tools for exploration of ionotropic kainate receptors

Principal investigator: dr hab. Ewa Monika Szymańska

Uniwersytet Jagielloński, Collegium Medicum

Call: OPUS 20, Panel: NZ7

32. Neuroprotective properties of 5-HT6 receptor ligands in the group of 2-arylpyrrole derivatives – a new insight into neur…

Principal investigator: Marcin Józef Drop

Uniwersytet Jagielloński, Collegium Medicum

Call: PRELUDIUM 17, Panel: NZ7

33. Application of machine learning based artificial intelligence to search for substances that modulate the activity of ROR…

Principal investigator: dr hab. Marcin Marek Ratajewski

Instytut Biologii Medycznej PAN

Call: OPUS 17, Panel: NZ7

34. Piperazine derivatives as active histamine H3 receptor ligands - molecular modeling, synthesis, pharmacological evaluati…

Principal investigator: Katarzyna Anna Szczepańska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: PRELUDIUM 12, Panel: NZ7

35. Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha…

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: SONATA 12, Panel: NZ7

36. 5-HT6 receptor ligands as addition to antipsychotic therapy in schizophrenia - an impact on body weight, metabolic param…

Principal investigator: prof. Anna Małgorzata Wesołowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 10, Panel: NZ7

37. Estrogen receptor GPER as a modulator of inflammatory and functional gastrointestinal diseases and colorectal cancer

Principal investigator: Damian Jacenik

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Call: PRELUDIUM 9, Panel: NZ5

38. LCAP biomimetics - alicyclic amine derivatives as a new class of monoaminergic receptor ligands

Principal investigator: dr hab. Paweł Maria Zajdel

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: OPUS 3, Panel: NZ7

39. Brain regions that mediate antipsychotic-induced changes in oscillatory activity recorded in the nucleus accumbens

Principal investigator: dr Mark Jeremy Hunt

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Call: OPUS 2, Panel: NZ4

40. Opioid receptors in the basal ganglia of the brain as targets for alcohol abuse therapy.

Principal investigator: dr Jan Manuel Rodriguez Parkitna

Instytut Farmakologii PAN

Call: OPUS 2, Panel: NZ4

41. Histamine H3/H4 receptors as the attractive target for the search of biologically active substances

Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: MAESTRO 1, Panel: NZ4

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