Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Estrogen receptor GPER as a modulator of inflammatory and functional gastrointestinal diseases and colorectal cancer

2015/17/N/NZ5/00336

Keywords:

Estrogen receptor GPER non-genomic estrogen signaling Crohn's disease ulcerative colitis irritable bowel syndrome colorectal cancer animal model of Crohn disease G-1 agonist of GPER G-15 antagonist of GPER

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ3_7: Signal transduction
  • NZ1_2: Biochemistry

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Damian Jacenik 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2016-02-22

Project end date (Y-m-d): 2019-02-21

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (3)
  • Book publications / chapters in book publications (2)
  1. G protein-coupled estrogen receptor in colon function, immune regulation and carcinogenesis
    Authors:
    Jacenik D, Beswick EJ, Krajewska WM, Prossnitz ER
    Academic press:
    World Journal of Gastroenterology (rok: 2019, tom: 25, strony: 4092-4104), Wydawca: Baishideng Publishing Group
    Status:
    Published
    DOI:
    10.3748/wjg.v25.i30.4092. - link to the publication
  2. Visualization of estrogen receptors in colons of mice with TNBS-induced Crohn's Disease using immunofluorescence
    Authors:
    Jacenik D., Zielińska M., Michlewska S., Fichna J., Krajewska W.M.
    Academic press:
    Journal of Visualized Experiments (rok: 2020, tom: 157, strony: e60813), Wydawca: MyJove Corp.
    Status:
    Published
    DOI:
    10.3791/60813 - link to the publication
  3. Sex- and age-related estrogen signaling alteration in inflammatory bowel diseases – modulatory role of estrogen receptors
    Authors:
    Jacenik D, Cygankiewicz AI, Mokrowiecka A, Małecka-Panas E, Fichna J, Krajewska WM
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: 3175), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20133175 - link to the publication
  4. Estrogen signaling deregulation related with local immune response modulation in irritable bowel syndrome
    Authors:
    Jacenik D, Cygankiewicz AI, Fichna J, Mokrowiecka A, Małecka-Panas E, Krajewska WM
    Academic press:
    Molecular and Cellular Endocrinology (rok: 2017, tom: 471, strony: 89-96), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mce.2017.07.036. - link to the publication
  5. G protein-coupled estrogen receptor mediates anti-inflammatory action in Crohn's disease
    Authors:
    Jacenik D, Zielińska M, Mokrowiecka A, Michlewska S, Małecka-Panas E, Kordek R, Fichna J, Krajewska WM
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 6749), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-43233-3 - link to the publication
  6. Significance of G protein-coupled estrogen receptor in the pathophysiology of irritable bowel syndrome, inflammatory bowel diseases and colorectal cancer
    Authors:
    Jacenik D., Krajewska W.M.
    Academic press:
    Frontiers in Endocrinology (rok: 2020, tom: 11, strony: 390), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fendo.2020.00390 - link to the publication
  7. G Protein-Coupled Receptor 30 (GPR30) Expression Pattern in Inflammatory Bowel Disease Patients Suggests its Key Role in the Inflammatory Process. A Preliminary Study
    Authors:
    Włodarczyk M, Sobolewska-Włodarczyk A, Cygankiewicz AI, Jacenik D, Piechota-Polańczyk A, Stec-Michalska K, Krajewska WM, Fichna J, Wiśniewska-Jarosińska M
    Academic press:
    The Journal of Gastrointestinal and Liver Diseases (rok: 2017, tom: 26, strony: 29-35), Wydawca: Medical University Press Cluj
    Status:
    Published
    DOI:
    10.15403/jgld.2014.1121.261.gpr - link to the publication
  1. From irritable bowel syndrome to colorectal cancer - impact of estrogen receptors
    Authors:
    Jacenik D, Cygankiewicz AI, Fichna J, Włodarczyk M, Mokrowiecka A, Dziki Ł, Małecka-Panas E, Dziki A, Krajewska WM
    Conference:
    X Parnas Conference Young Scientist Forum "Molecules in the Living Cell and Innovative Medicine" (rok: 2016, ), Wydawca: ACTA BIOCHEMICA POLONICA
    Data:
    konferencja 10-12.07.2016
    Status:
    Published
    DOI:
    link to the publication
  2. Activation of G protein-coupled estrogen receptor mediates anti-inflammatory effect in Crohn's disease
    Authors:
    Jacenik D, Cygankiewicz AI, Zielińska M, Włodarczyk M, Sobolewska-Włodarczyk A, Wiśniewska-Jarosińska M, Fichna J, Krajewska WM
    Conference:
    42nd Federation of European Biochemical Societies Congress (rok: 2017, ), Wydawca: Wiley Online Library
    Data:
    konferencja 10-14.09.2017
    Status:
    Published
  3. G protein-coupled estrogen receptor and nuclear estrogen receptors activity modulation in murine model of colitis-associated colorectal cancer
    Authors:
    Jacenik D, Zielińska M, Fichna J, Krajewska WM
    Conference:
    44th Federation of European Biochemical Societies Congress (rok: 2019, ), Wydawca: nie dotyczy
    Data:
    konferencja 06-11.07.2019
    Status:
    Published
    DOI:
    link to the publication
  1. Gender-related differences and significance of gonadal hormones in irritable bowel syndrome
    Authors:
    Jacenik D.
    Book:
    A Comprehensive Overview of Irritable Bowel Syndrome: Clinical and Basic Science Aspects (rok: 2020, tom: 6, strony: 69-83), Wydawca: Academic Press
    Status:
    Published
  2. Risk Factors in Colorectal Cancer
    Authors:
    Jacenik D, Cygankiewicz AI, Krajewska WM
    Book:
    Introduction to Gastrointestinal Diseases Vol. 2 (rok: 2017, tom: 2, strony: 113-128), Wydawca: Springer International Publishing
    Status:
    Published

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