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Analysis of the anti-nociceptive and anti-inflammatory action of histamine H4 receptor antagonist in inflammatory nociceptive pain. Attempt to explain its mechanism.

2011/03/N/NZ4/03765

Keywords

Descriptors

  • NZ4_4: Patofizjologia ogólna
  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Instytut Reumatologii im. prof. dr hab. med. Eleonory Reicher

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Przemysław Rzodkiewicz

Number of co-investigators in the project: 3

Call

PRELUDIUM 2 – announced on 2011-09-15

Amount awarded
325 920 PLN
Project start date
2012-08-20
Project end date
2014-12-19
Project duration
28 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Czytnik ELISA. Cost: 26 000 PLN
  2. Mieszadło magnetyczne MSH-300i. Cost: 2 575 PLN

Information in the final report

Publication in academic press/journals (2)

  1. Antinociceptive properties of esculetin in non-inflammatory and inflammatory models of pain in rats

    Authors:
    Przemyslaw Rzodkiewicz, Emilia Gasinska, Slawomir Maslinski, Magdalena Bujalska-Zadrozny
    Academic press:
    Clinical and Experimental Pharmacology and Physiology (year: 2015, volume: 42, pages: 213 – 219), Publisher: Wiley-Blackwell
    Status:
    Published
    DOI:
    link to the publication

  2. Esculetin reduces leukotriene B4 level in plasma of rats with adjuvant-induced arthritis

    Authors:
    Rzodkiewicz P, Gąsińska E, Gajewski M, Bujalska-Zadrożny M, Szukiewicz D, Maśliński S.
    Academic press:
    Reumatologia (year: 2016, volume: 54 (4), pages: 161-164), Publisher: Termedia
    Status:
    Published
    DOI:
    10.5114/reum.2016.62469 – link to the publication

Articles in post-conference publications (9)

  1. EVIDENCE FOR ANALGESIC ACTION OF AESCULETIN IN CARRAGEENAN INDUCED INFLAMMATION

    Authors:
    P. Rzodkiewicz, E. Gąsińska
    Conference:
    European Histamine Research Society 42nd Annual Meeting (year: 2013, pages: 17-18), Publisher: Springer
    Date:
    conference 8-11 maja
    Status:
    Published
    DOI:
    link to the publication

  2. ANTINOCICEPTIVE ACTION OF JNJ7777120 IN ACUTE PAIN MODELS AND ITS INTERACTIONS WITH ARACHIDONIC ACID DERIVATIVES INHIBITORS

    Authors:
    P. Rzodkiewicz, E. Gąsińska, D. Łażewska, M. Bujalska-Zadrożny, D. Maślińska, K. Kieć-Kononowicz, E. Wojtecka-Łukasik, D. Szukiewicz, S. Maśliński
    Conference:
    European Histamine Research Society 42nd Annual Meeting (year: 2013, pages: 18), Publisher: Springer
    Date:
    conference 8-11 maja
    Status:
    Published
    DOI:
    link to the publication

  3. Przeciwbólowe działanie eskuletyny w niezapalnym i zapalnym bólu ostrym

    Authors:
    Przemysław Rzodkiewicz, Emilia Gąsińska, Magdalena Bujalska-Zadrożny, Sławomir Maśliński
    Conference:
    BÓL PRZEWLEKŁY, MECHANIZMY, TERAPIA- XXX Zimowa Szkoła Instytutu Farmakologii PAN (year: 2013, pages: 175), Publisher: Instytut Farmakologii PAN w Krakowie
    Date:
    conference 19-22 luty
    Status:
    Published

  4. Wpływ pochodnych kwasu arachidonowego na antynocyceptywne działanie JNJ7777120

    Authors:
    Przemysław Rzodkiewicz, Emilia Gąsińska, Dorota Łażewska, Magdalena Bujalska-Zadrożny, Krystyna Cegielska-Perun, Katarzyna Kieć-Kononowicz, Sławomir Maśliński
    Conference:
    BÓL PRZEWLEKŁY, MECHANIZMY, TERAPIA- XXX Zimowa Szkoła Instytutu Farmakologii PAN (year: 2013, pages: 177), Publisher: Instytut Farmakologii PAN w Krakowie
    Date:
    conference 19-22 luty
    Status:
    Published

  5. Role of histamine H4 receptor in nociception

    Authors:
    P. Rzodkiewicz, E. Gąsińska, D. Łażewska, K. Kieć-Kononowicz, S. Maśliński, M. Bujalska-Zadrożny
    Conference:
    European Histamine Research Society 43rd Annual Meeting (year: 2014, pages: 17), Publisher: Springer
    Date:
    conference 7-10 maja
    Status:
    Published
    DOI:
    link to the publication

  6. Influence of cyclooxygenase inhibitors on antihyperalgesic action of JNJ7777120 in adjuvant induced arthritis

    Authors:
    P. Rzodkiewicz, E. Gąsińska, D. Łażewska, K. Kieć-Kononowicz, S. Maśliński, M. Bujalska-Zadrożny
    Conference:
    European Histamine Research Society 43rd Annual Meeting (year: 2014, pages: 18), Publisher: Springer
    Date:
    conference 7-10 maja
    Status:
    Published
    DOI:
    link to the publication

  7. MEDIATORS OF INFLAMMATION IN THE ANTINOCICEPTIVE ACTION OF JNJ7777120 IN RATS

    Authors:
    P. Rzodkiewicz, E. Gąsińska, D. Łażewska, K. Kieć-Kononowicz, Bujalska- Zadrożny, S. Maśliński
    Conference:
    European Histamine Research Society 45th Annual Meeting (year: 2016, pages: S19), Publisher: Springer
    Date:
    conference 11-14 maja
    Status:
    Published

  8. Influence of arachidonic acid derivatives on antinociceptive action of JNJ7777120

    Authors:
    Przemysław Rzodkiewicz, Emilia Gąsińska, Dorota Łażewska, Magdalena Bujalska-Zadrożny, Krystyna Cegielska-Perun, Katarzyna Kieć-Kononowicz, Sławomir Maśliński
    Conference:
    18TH INTERNATIONAL CONGRESS OF THE POLISH PHARMACOLOGICAL SOCIETY (year: 2013, pages: 82), Publisher: Instytut Farmakologii PAN w Krakowie
    Date:
    conference 23-25 maja
    Status:
    Published

  9. H4R ANTAGONIST AND NITRIC OXIDE INHIBITORS: INTERACTIONS IN ANTINOCICEPTION

    Authors:
    P. Rzodkiewicz, E. Gąsińska, M. Skoda, D. Łażewska, K. Kieć-Kononowicz, D. Szukiewicz, M. Bujalska- Zadrożny, S. Maśliński
    Conference:
    European Histamine Research Society 44th Annual Meeting (year: 2015, pages: S23), Publisher: Springer
    Date:
    conference 6-9 maja
    Status:
    Published

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