Projects funded by the NCN
Dual 5-HT3 receptor/5-HT6 receptor antagonists in neuropsychiatric and neurological disorders
2021/43/B/NZ7/02855
Keywords:
5-HT3/5-HT6 antagonism dual acting compounds neutral antagonism inverse agonism schizophrenia irritable-bowel syndrom
Descriptors:
- NZ7_014:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Jagielloński, Collegium Medicum
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 15
Call: OPUS 22 - announced on 2021-09-15
Amount awarded: 3 601 928 PLN
Project start date (Y-m-d): 2022-07-18
Project end date (Y-m-d): 2026-07-17
Project duration:: 48 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- Superiority of the Triple-Acting 5-HT6R/5-HT3R Antagonist and MAO-B Reversible Inhibitor PZ-1922 over 5-HT6R Antagonist Intepirdine in Alleviation of Cognitive Deficits in RatsAuthors:Katarzyna Grychowska, Uriel López-Sánchez, Mathieu Vitalis, Geoffrey Canet, Grzegorz Satała, Agnieszka Olejarz-Maciej, Joanna Gołębiowska, Rafał Kurczab, Wojciech Pietruś, Monika Kubacka, Christophe Moreau, Maria Walczak, Klaudia Blicharz-Futera, Ophélie Bento, Xavier Bantreil, Gilles Subra, Andrzej J. Bojarski, Frédéric Lamaty, Carine Becamel, Charleine Zussy, Séverine Chaumont-Dubel, Piotr Popik, Hugues Nury, Philippe Marin, Laurent Givalois, Paweł ZajdelAcademic press:Journal of Medicinal Chemistry (rok: 2023, tom: 21, strony: 14928–14947), Wydawca: American Chemical SocietyStatus:PublishedDOI:10.1021/acs.jmedchem.3c01482 - link to the publication
- Effects of ketamine on rat social behavior as analyzed by DeepLabCut and SimBA deep learning algorithmsAuthors:Piotr Popik, Ewelina Cyrano, Diana Piotrowska, Malgorzata Holuj, Joanna Golebiowska, Natalia Malikowska-Racia, Agnieszka Potasiewicz, Agnieszka NikiforukAcademic press:Frontiers in Pharmacology (rok: 2024, tom: 14, strony: 1329424), Wydawca: FrontiersStatus:PublishedDOI:10.3389/fphar.2023.1329424 - link to the publication