Development of a method for the structure prediction of GPCRs complexes with agonists and antagonists, including the ligand-induced alternations of the receptor structure
2011/01/D/NZ2/05314
Keywords
Descriptors
- NZ2_10: Modelowanie i symulacje biologiczne
- NZ2_7: Bioinformatyka
- NZ2_8: Biologia obliczeniowa
Panel
NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology
Host institution
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
SONATA 1 – announced on 2011-03-15
- Amount awarded
- 336 900 PLN
- Project start date
- 2011-12-07
- Project end date
- 2015-12-06
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Latitude E6430 Standart Base.
- Serwer PowerEdge R620. Cost: 60 000 PLN
Information in the final report
Publication in academic press/journals (2)
-
Recent progress in understanding of structure, ligand interactions and the mechanism of activation of the β₂-adrenergic receptor.
- Authors:
- Kolinski M, Plazinska A, Jozwiak K.
- Academic press:
- Curr Med Chem. (year: 2012, volume: 8, pages: 1155-1163 (9)), Publisher: Bentham Science Publishers
- Status:
- Published
- DOI:
- 10.2174/092986712799320547 – link to the publication
-
Structure prediction of the second extracellular loop in G-protein-coupled receptors
- Authors:
- Sebastian Kmiecik , Michal Jamroz, Michal Kolinski
- Academic press:
- Biophysical Journal (year: 2014, volume: 106(11), pages: 2408-2416), Publisher: Cell Press, www.cell.com
- Status:
- Published
- DOI:
- 10.1016/j.bpj.2014.04.022. – link to the publication
Book publications / chapters in book publications (2)
-
Modelowanie molekularne białek błonowych
- Authors:
- Aleksandra ED, Koliński M, Koliński A, Kmiecik S.
- Book:
- Na pograniczu chemii i biologii (year: 2012, volume: XXVIII, pages: 223-237), Publisher: Wydawnictwo Naukowe Uniwersytetu im. Adama Mickiewicza
- Status:
- Published
- DOI:
- link to the publication
-
Coarse-grained modeling of protein dynamics
- Authors:
- Kmiecik S, Wabik J, Kolinski M, Kouza M and Kolinski A.
- Book:
- Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes (year: 2014, volume: 1, pages: 55-79), Publisher: Springer Berlin Heidelberg
- Status:
- Published
- DOI:
- link to the publication