Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Development of a method for the structure prediction of GPCRs complexes with agonists and antagonists, including the ligand-induced alternations of the receptor structure

2011/01/D/NZ2/05314

Keywords:

GPCR flexible docking structure prediction ligand binding loop modeling drug design

Descriptors:

  • NZ2_10: Biological systems analysis, modelling and simulation
  • NZ2_7: Bioinformatics
  • NZ2_8: Computational biology

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Michał Koliński 

Number of co-investigators in the project: 6

Call: SONATA 1 - announced on 2011-03-15

Amount awarded: 336 900 PLN

Project start date (Y-m-d): 2011-12-07

Project end date (Y-m-d): 2015-12-06

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Serwer PowerEdge R620 (60 000 PLN)
  2. Latitude E6430 Standart Base.

Information in the final report

  • Publication in academic press/journals (3)
  • Book publications / chapters in book publications (2)
  1. Structure prediction of the second extracellular loop in G-protein-coupled receptors
    Authors:
    Sebastian Kmiecik , Michal Jamroz, Michal Kolinski
    Academic press:
    Biophysical Journal (rok: 2014, tom: 106(11), strony: 2408-2416), Wydawca: Cell Press, www.cell.com
    Status:
    Published
    DOI:
    10.1016/j.bpj.2014.04.022. - link to the publication
  2. A CABS coarse-grained model for de novo simulations of helical membrane proteins
    Authors:
    Wojciech Pulawski, Michal Jamroz, Michal Kolinski, Andrzej Kolinski, Sebastian Kmiecik
    Academic press:
    Journal of Chemical Theory and Computation (rok: 2016, ), Wydawca: American Chemical Society
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Recent progress in understanding of structure, ligand interactions and the mechanism of activation of the β₂-adrenergic receptor.
    Authors:
    Kolinski M, Plazinska A, Jozwiak K.
    Academic press:
    Curr Med Chem. (rok: 2012, tom: 8, strony: 1155-1163 (9)), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/092986712799320547 - link to the publication
  1. Coarse-grained modeling of protein dynamics
    Authors:
    Kmiecik S, Wabik J, Kolinski M, Kouza M and Kolinski A.
    Book:
    Computational Methods to Study the Structure and Dynamics of Biomolecules and Biomolecular Processes (rok: 2014, tom: 1, strony: 55-79), Wydawca: Springer Berlin Heidelberg
    Status:
    Published
    DOI:
    link to the publication
  2. Modelowanie molekularne białek błonowych
    Authors:
    Aleksandra ED, Koliński M, Koliński A, Kmiecik S.
    Book:
    Na pograniczu chemii i biologii (rok: 2012, tom: XXVIII, strony: 223-237), Wydawca: Wydawnictwo Naukowe Uniwersytetu im. Adama Mickiewicza
    Status:
    Published
    DOI:
    link to the publication

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