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Information of the project and the call

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Co-crystallization and co-amorphization of angiotensin II receptor blockers leading to more soluble compounds with a bifunctional character

2019/33/N/ST5/01602

Keywords:

angiotensin II receptor blockers valsartan losartan telmisartan cocrystals solid dispersions solubility ultrasounds

Descriptors:

  • ST5_002:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Akademia im. Jana Długosza w Częstochowie

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marika Ewa Turek 

Number of co-investigators in the project: 2

Call: PRELUDIUM 17 - announced on 2019-03-15

Amount awarded: 210 000 PLN

Project start date (Y-m-d): 2020-01-31

Project end date (Y-m-d): 2025-01-30

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (3)
  1. Mechanochemical synthesis of telmisartan-based co-amorphous solid dispersions with enhanced solubility and unexpected cytotoxic synergy on normal cell lines
    Authors:
    Marika Turek, Katarzyna Gach-Janczak, Ewa Różycka-Sokołowska, Krzysztof Owsianik, Piotr Bałczewski
    Academic press:
    Advanced Powder Technology (rok: 2025, tom: 36, strony: 104936), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.apt.2025.104936 - link to the publication
  2. Role of Hydrogen Bonds in Formation of Co-amorphous Valsartan/Nicotinamide Compositions of High Solubility and Durability with Anti-hypertension and Anti-COVID-19 Potential
    Authors:
    M. Turek, E. Różycka-Sokołowska, M. Koprowski, B. Marciniak, P. Bałczewski
    Academic press:
    Molecular Pharmaceutics (rok: 2021, tom: 18, strony: 1970−1984), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.0c01096 - link to the publication
  3. New Perspectives for Antihypertensive Sartans as Components of Co-crystals and Co-amorphous Solids with Improved Properties and Multipurpose Activity
    Authors:
    Marika Turek, Ewa Różycka-Sokołowska, Krzysztof Owsianik, Piotr Bałczewski
    Academic press:
    Molecular Pharmaceutics (rok: 2024, tom: 21, strony: 18-37), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.3c00959 - link to the publication
  1. Enhancing stability: co-amorphous pharmaceutical solid dispersions of antihypertensive sartans and ascorbic acid for cardioprotecion
    Authors:
    Patrycja Miara, Marika Turek, Ewa Różycka-Sokołowska, Piotr Bałczewski
    Conference:
    3rd International Conference CHEMISTRY FOR BEAUTY AND HEALTH Book of Abstracts (rok: 2024, tom: 3rd International Conference CHEMISTRY FOR BEAUTY AND HEALTH, strony: 75), Wydawca: Politechnika Krakowska
    Data:
    konferencja 13-15.06.2024r.
    Status:
    Published
    DOI:
    link to the publication
  2. Co-amorphization of candesartan cilexetil with polyphenols: mechanochemical and solvent-based approaches
    Authors:
    Patrycja Miara , Marika Turek , Piotr Bałczewski
    Conference:
    XXV International Symposium Advances in the Chemistry of Heteroorganic Compounds and XXII International Symposium on Selected Problems of Chemistry of Acyclic and Cyclic Heteroorganic Compounds (rok: 2024, tom: XXV International Symposium Advances in the Chemistry of Heteroorganic Compounds, strony: P2-031), Wydawca: Wydawnictwo Naukowe Uniwersytetu Humanistyczno-Przyrodniczego im. Jana Długosza w Częstochowie
    Data:
    konferencja 21-22.11.2024r.
    Status:
    Published
  3. KO-AMORFIZACJA CYLEKSETYLU KANDESARTANU Z POLIFENOLAMI: SYNTEZA ROZPUSZCZALNIKOWA
    Authors:
    Patrycja Miara , Marika Turek , Piotr Bałczewski
    Conference:
    XI Forum Młodych Naukowców: Nauki przyrodnicze i medyczne (rok: 2024, tom: XI Forum Młodych Naukowców, strony: 275), Wydawca: Wydawca Stowarzyszenie Młodych Naukowców
    Data:
    konferencja 6-7.12.2024r.
    Status:
    Published

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