Radiopharmaceuticals based on neurokinin-1 receptor antagonists for the diagnosis and therapy of a brain tumour - glioblastoma multiforme.
2017/25/B/NZ7/01896
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- ST5_16: Chemia biologiczna
- ST4_16: Chemia jądrowa i radiacyjna
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN
Voivodeship: mazowieckie
Principal investigator (from the host institution)
prof. Aleksandra Misicka-Kęsik
Number of co-investigators in the project: 9
Call
OPUS 13 – announced on 2017-03-15
- Amount awarded
- 961 230 PLN
- Project start date
- 2018-02-15
- Project end date
- 2022-02-14
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Homogenizator. Cost: 6 000 PLN
- Mikrowirówka.
- Myjka ultradźwiękowa. Cost: 3 600 PLN
- Nowoczesny komputer z akcesoriami. Cost: 13 000 PLN
- Pompa strzykawka ze sterownikiem.
- Stacja wodna. Cost: 10 776 PLN
- Suchy blok grzejny (termoblok). Cost: 6 000 PLN
- Urządzenie filtracyjne do płytek 96-dołkowych z oprzyrządowaniem. Cost: 76 000 PLN
- Vortex z akcesoriami. Cost: 3 400 PLN
- Wirnik (rotor) do wirówki. Cost: 8 000 PLN
- Wirówka laboratoryjna z wymiennymi rotorami. Cost: 30 000 PLN
- Zbiornik na ciekły azot (Dewar).
Information in the final report
Publication in academic press/journals (5)
-
The Significance of NK1 Receptor Ligands and Their Application in Targeted Radionuclide Tumour Therapy
- Authors:
- Agnieszka Majkowska-Pilip, Paweł Krzysztof Halik, Ewa Gniazdowska
- Academic press:
- Pharmaceutics (year: 2019, volume: 11, pages: 443), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/pharmaceutics11090443 – link to the publication
-
Novel NK1R-Targeted 68Ga-/177Lu-Radioconjugates with Potential Application against Glioblastoma Multiforme: Preliminary Exploration of Structure–Activity Relationships
- Authors:
- Joanna Matalińska, Katarzyna Kosińska, Paweł K. Halik, Przemysław Koźmiński, Piotr F. J. Lipiński, Ewa Gniazdowska, Aleksandra Misicka
- Academic press:
- International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 1214), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms23031214 – link to the publication
-
Application of Neurokinin-1 Receptor in Targeted Strategies for Glioma Treatment. Part I: Synthesis and Evaluation of Substance P Fragments Labeled with 99mTc and 177Lu as Potential Receptor Radiopharmaceuticals
- Authors:
- Agnieszka Majkowska-Pilip, Przemysław Koźmiński, Anna Wawrzynowska, Tadeusz Budlewski, Bogusław Kostkiewicz, Ewa Gniazdowska
- Academic press:
- Molecules (year: 2018, volume: 23, pages: 2542), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/molecules23102542 – link to the publication
-
In Vitro Biological Evaluation of Aprepitant Based 177Lu-Radioconjugates
- Authors:
- Halik, P.; Koźmiński, P.; Matalińska, J.; Lipiński, P.F.J.; Misicka, A.; Gniazdowska, E.
- Academic press:
- Pharmaceutics (year: 2022, volume: 14, pages: 607), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/pharmaceutics14030607 – link to the publication
-
Radiochemical Synthesis and Evaluation of Novel Radioconjugates of Neurokinin 1 Receptor Antagonist Aprepitant Dedicated for NK1R-Positive Tumors
- Authors:
- Halik, P. K.; Lipiński, P.F.J.; Matalińska, J.; Koźmiński, P.; Misicka, A.; Gniazdowska E.
- Status:
- Accepted for publication