Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Non-quinazoline antagonists of apha1 and 5-HT2A receptors with pleiotropic effects as a new perspective for hypertension and metabolic syndrome treatment

2014/15/D/NZ7/01807

Keywords:

hypertension metabolic syndrome alpha1-adrenoceptors 5-HT2A aggregation endothelium left ventricular hypertrophy apoptosis

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Monika Kubacka 

Number of co-investigators in the project: 8

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 377 800 PLN

Project start date (Y-m-d): 2015-07-15

Project end date (Y-m-d): 2020-01-14

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Agregometr do mierzenia agregacji płytek w krwi pełnej (120 000 PLN)
  2. komputer i drukarka (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. MH-76, a Novel Non-Quinazoline 1-Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats
    Authors:
    Kubacka M, Mogilski S, Zadrożna M, Nowak B, Szafarz M, Pomierny B, Marona H, Waszkielewicz A, Jawień W, Sapa J, Bednarski M, Knutelska J, Kotańska M.
    Academic press:
    Pharmaceuticals (Basel) (rok: 2021, tom: 14(5), strony: 477), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14050477. - link to the publication
  2. Anti-aggregation effect of aroxyalkyl derivatives of 2-methoxyphenylpiperazine is due to their 5-HT2A and α2-adrenoceptor antagonistic properties. A comparison with ketanserin, sarpogrelate, prazosin, yohimbine and ARC239.
    Authors:
    Kubacka M, Kazek G, Kotańska M, Filipek B, Waszkielewicz AM, Mogilski S.
    Academic press:
    Eur J Pharmacol (rok: 2018, tom: 818, strony: 263-270), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.053 - link to the publication
  3. Beneficial effects of non-quinazoline α1-adrenolytics on hypertension and altered metabolism in fructose-fed rats. A comparison with prazosin.
    Authors:
    Kubacka M, Kotańska M, Szafarz M, Pociecha K, Waszkielewicz AM, Marona H, Filipek B, Mogilski S
    Academic press:
    Nutr Metab Cardiovasc Dis (rok: 2019, tom: 29, strony: 751-760), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.numecd.2019.04.003. - link to the publication
  4. Reversal of cardiac, vascular and renal dysfunction by non-quinazoline α1-adrenolytics in DOCA-salt hypertensive rats: A comparison with prazosin, a quinazoline-based α1-adrenoceptor antagonist
    Authors:
    Monika Kubacka, Monika Zadrożna, Barbara Nowak, Magdalena Kotańska, Barbara Filipek, Anna Maria Waszkielewicz, Henryk Marona, Szczepan Mogilski
    Academic press:
    Hypertension Research (rok: 2019, tom: 42 (8), strony: 1125-1141), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41440-019-0239-1 - link to the publication
  5. Involvement of the NO/sGC/cGMP/K+ channels pathway in vascular relaxation evoked by two non-quinazoline α1-adrenoceptor antagonists
    Authors:
    Monika Kubacka, Magdalena Kotańska, Grzegorz Kazek, Anna Maria Waszkielewicz, Henryk Marona, Barbara Filipek, Szczepan Mogilski
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2018, tom: 103, strony: 157-166), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2018.04.034. - link to the publication

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