Projects funded by the NCN

The molecular basis of stress-induced anxiety and affective disorders

Call: OPUS 2 , Panel: NZ2

Principal investigator: dr Michał Korostyński

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Dioscuri Center for Structural Dynamics of Receptors

Call: DIOSCURI 1 , Panel: NZ1

Principal investigator: Przemysław Nogły

Uniwersytet Jagielloński

Antibacterial molecules based on bacteriophage proteins and constant antibody fragments with therapeutic potential for t...

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Karolina Aleksandra Filik-Matyjaszczyk

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

2-in-1: Octafluoroazobenzenes as ON/OFF photoswitches and anion-binding sites in macrocyclic lithium halides receptors

Call: PRELUDIUM 23 , Panel: ST5

Principal investigator: Jakub Narodowiec

Instytut Chemii Organicznej Polskiej Akademii Nauk

Cellular effects in the tumor microenvironment and the potential for targeted delivery of molecules associated with the ...

Call: OPUS 27 , Panel: NZ4

Principal investigator: prof. Magdalena Maria Staniszewska

Katolicki Uniwersytet Lubelski Jana Pawła II

Macro-to-Micro: Fabrication of synthetic receptor based microsensors for certain protein sensing

Call: OPUS 27 , Panel: ST11

Principal investigator: dr hab. Piyush Sindhu Sharma

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Molecular mechanisms underlying the liver injury induced by ulipristal acetate treatment

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Aleksandra Natalia Łupińska

Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk

Zn2+-dependent competition between CD4 and CD8α coreceprtor for Lck tyrosine kinase

Call: SONATA 19 , Panel: NZ1

Principal investigator: dr Anna Marta Kocyła

Uniwersytet Wrocławski, Wydział Biotechnologii

Deciphering the importance of the intracellular FGFR1 module for cell fate

Call: OPUS 26 , Panel: NZ1

Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

Uniwersytet Wrocławski, Wydział Biotechnologii

Retro-inverso modification of zinc(II)–GLP-1 receptor agonist complexes – from bioinorganic chemistry to animal studies...

Call: OPUS 26 , Panel: ST5

Principal investigator: dr hab. Magdalena Alina Rowińska-Żyrek

Uniwersytet Wrocławski, Wydział Chemii

First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Jadwiga Handzlik

Uniwersytet Jagielloński, Collegium Medicum

Integrated multi-omics approach to accelerate anticancer drug discovery by targeting metabolic reprogramming in human co...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr hab. Danuta Dudzik

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Proteolytic processing of adhesion G-protein coupled receptors through proteases

Call: WEAVE-UNISONO , Panel: NZ1

Principal investigator: dr Renata Mężyk-Kopeć

Uniwersytet Jagielloński

Study on novel sensing layers for determination of quorum sensing signal molecules

Call: SONATA BIS 13 , Panel: ST5

Principal investigator: dr hab. Kamila Sadowska

Instytut Biocybernetyki i Inżynierii Biomedycznej im. Macieja Nałęcza Polskiej Akademii Nauk

Crownphyrins - hybrids of crown ethers and porphyrins, constituting macrocyclic platforms for the construction of two- a...

Call: PRELUDIUM BIS 5 , Panel: ST4

Principal investigator: dr hab. Bartosz Jakub Szyszko

Uniwersytet Wrocławski, Wydział Chemii

Novel receptor materials for the construction of a bioelectronic nose for the rapid and efficient detection of lung canc...

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Wojciech Kamysz

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Molecular geometry – pre- and post-synthetically modified shape-persistent macrocycles of great chiroptical response, fo...

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Marcin Grzegorz Kwit

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

"I like to move it, move it" – molecular dynamics-driven optimization of ligand residence time as an opportunity to impr...

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr hab. Sabina Marta Podlewska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Study of ligand binding and activation processes of formyl, opioid and cannabinoid G-protein-coupled receptors

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Sławomir Hubert Filipek

Uniwersytet Warszawski, Wydział Chemii

Psychedelic-induced molecular changes in the brain

Call: SONATINA 7 , Panel: NZ2

Principal investigator: dr Dominik Łukasz Cysewski

Uniwersytet Medyczny w Białymstoku

Function, organization, dynamics, and evolution of hyperbranched receptor-binding protein systems in Klebsiella jumbo ph...

Call: OPUS 24 (LAP) , Panel: NZ1

Principal investigator: prof. Zuzanna Drulis-Kawa

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

In vitro and in vivo investigations of the radiometals influence on the ability of CCK2R receptors imaging by the radiol...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Renata Radosława Mikołajczak

Narodowe Centrum Badań Jądrowych

Molecular implications of gut microbiota disorders in the context of the immune system functioning in patients with prim...

Call: OPUS 23 , Panel: NZ6

Principal investigator: prof. Ewelina Pia Grywalska

Uniwersytet Medyczny w Lublinie

Proinsulin C-peptide and G protein-coupled receptor 146 (GPR146) – clinical investigation of the impact of their signall...

Call: PRELUDIUM 21 , Panel: NZ4

Principal investigator: Aleksandra Ryk

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Highly-internalizing intrinsically fluorescent oligomeric cytotoxic conjugate targeting breast cancer cells overproducin...

Call: PRELUDIUM 21 , Panel: NZ1

Principal investigator: dr Natalia Porębska

Uniwersytet Wrocławski, Wydział Biotechnologii

Use of comparative oncology approach to dissect the PD-1 intrinsic signalling in osteosarcoma. Can dog be the key for ne...

Call: PRELUDIUM 21 , Panel: NZ1

Principal investigator: Katarzyna Joanna Dziubek

Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

The evaluation of therapeutic potential of β-caryophyllene in animal schizophrenia model - behavioral and molecular stud...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: dr Magdalena Białoń

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Peptide receptor complexes for auxin canalization and regeneration in Arabidopsis.

Call: OPUS 22 (LAP) , Panel: NZ1

Principal investigator: dr Ewa Mazur

Uniwersytet Śląski w Katowicach, Wydział Nauk Przyrodniczych

Synthesis and applications of sumanene derivatives as innovative, selective and effective molecular receptors of caesium...

Call: OPUS 22 , Panel: ST4

Principal investigator: dr Artur Kasprzak

Politechnika Warszawska, Wydział Chemiczny

Brain GABAB receptors as determinants of obesity phenotypes: evaluation of adolescent female and male rats

Call: OPUS 22 , Panel: NZ5

Principal investigator: prof. Małgorzata Maria Filip

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The interplay of neurochemistry and cancer biology: in the search for novel glioblastoma multiforme therapy among dopami...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Katarzyna Maria Kucwaj-Brysz

Uniwersytet Jagielloński, Collegium Medicum

FGFR2-->JunB axis in progression of ER+ breast cancer - molecular analyses and prognostication

Call: PRELUDIUM BIS 3 , Panel: NZ3

Principal investigator: dr hab. Rafał Sebastian Sądej

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Molecular mechanisms of 5-HT7R-mediated resilience in stress-related disorders

Call: OPUS 21 , Panel: NZ4

Principal investigator: prof. Jakub Mateusz Włodarczyk

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Design of metal-peptide complexes based on amyloid β sequence with a His-2 binding motif as selective receptors in elect...

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: Aleksandra Magdalena Tobolska

Politechnika Warszawska

Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

Cooperative and collective phenomena in cell membrane adhesion

Call: SHENG 2 , Panel: NZ1

Principal investigator: dr hab. Bartosz Jan Różycki

Instytut Fizyki Polskiej Akademii Nauk

Assessing protein-ligand complexes with ML/DL models trained on molecular dynamics-based descriptors.

Call: OPUS 20 , Panel: ST4

Principal investigator: dr hab. Paweł Aleksander Siedlecki

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

Self-learning systems in the design of compounds modulating GPCR receptors activation.

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Parallel quantitative evaluation of targetability, cellular uptake, and intracellular drug release for the establishment...

Call: OPUS 20 (LAP) , Panel: ST5

Principal investigator: prof. Adolfo Rivero Müller

Uniwersytet Medyczny w Lublinie, Wydział Nauk Medycznych

Identification and characterisation of novel anti-bacterial restriction factors

Call: Polskie Powroty NAWA 2020 , Panel: NZ1

Principal investigator: dr Michał Piotr Wandel

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

The influence of environment on biomolecular function, structure and interactions.

Call: SONATA BIS 10 , Panel: ST4

Principal investigator: dr hab. Piotr Mikołaj Setny

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of gliobl...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: dr Przemysław Patryk Zaręba

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

Molecular mechanism underlying the anti-inflammatory action of CB2 receptor agonists in microglia: participation of the ...

Call: OPUS 19 , Panel: NZ7

Principal investigator: dr Natalia Eleonora Małek-Chudzik

Politechnika Wrocławska

FAST interactions in cell death regulation

Call: PRELUDIUM 19 , Panel: NZ1

Principal investigator: Daria Martyna Dawidziak

Uniwersytet Warszawski, Wydział Chemii

Making use of siderophore transport systems to deliver peptide nucleic acids to bacterial cells

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Joanna Dominika Trylska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Determination of the mechanisms responsible for the mobility of non-integrin laminin receptor (LamR) isoforms, including...

Call: PRELUDIUM 19 , Panel: NZ1

Principal investigator: Ewa Mazurkiewicz

Uniwersytet Wrocławski, Wydział Biotechnologii

Role of the Intersubunit and Interdomain Interactions in the GABAA Receptor Modulation by Protons.

Call: ETIUDA 8 , Panel: NZ1

Principal investigator: Michał Adam Michałowski

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Chasing the HARE: elucidation of the binding mechanism of the new and unexplored ligandsof the Hyaluronic Acid Receptor ...

Call: SONATINA 4 , Panel: NZ1

Principal investigator: dr Aleksandra Anna Twarda-Cłapa

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor...

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Seeking for CB1 and CB2 receptor ligands among drugs, drug metabolites, and phytochemical compounds

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Adam Stasiulewicz

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego