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Molecular and functional analysis of interleukin 18 (IL-18) its receptor (IL-18R) and IL-18- binding protein (IL-18BP) in active tuberculosis and latent tuberculosis infection

2015/19/N/NZ6/01385

Keywords

Descriptors

  • NZ6_2: Immunologia kliniczna
  • NZ6_1: Odporność swoista i nieswoista

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Sebastian Wawrocki

Number of co-investigators in the project: 2

Call

PRELUDIUM 10 – announced on 2015-09-15

Amount awarded
144 000 PLN
Project start date
2016-09-02
Project end date
2019-09-01
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (4)

  1. Lack of significant effect of interleukin-18 gene variants on tuberculosis susceptibility in the Polish population.

    Authors:
    Sebastian Wawrocki, Grzegorz Kielnierowski, Wiesława Rudnicka, Magdalena Druszczyńska
    Academic press:
    Acta Biochimica Polonica (year: 2019, volume: 66, pages: 337–342), Publisher: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/abp.2019_2797 – link to the publication

  2. Inflammasomes in Mycobacterium tuberculosis-Driven Immunity

    Authors:
    Sebastian Wawrocki, Magdalena Druszczynska
    Academic press:
    Canadian Journal of Infectious Diseases and Medical Microbiology (year: 2017, volume: Volume 2017, pages: 9), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/2309478 – link to the publication

  3. IL-18/IL-37/IP-10 signaling complex as a potential biomarker for discriminating active and latent TB

    Authors:
    Sebastian Wawrocki, Michal Seweryn, Grzegorz Kielnierowski, Wiesława Rudnicka, Marcin Włodarczyk, Magdalena Druszczyńska
    Academic press:
    PlosOne (year: 2019, volume: 14(12), pages: e0225556), Publisher: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0225556 – link to the publication

  4. Interleukin-18, Functional IL-18 Receptor and IL-18 Binding Protein Expression in Active and Latent Tuberculosis.

    Authors:
    Sebastian Wawrocki, Grzegorz Kielnierowski, Wiesława Rudnicka, Michał Seweryn, Magdalena Druszczynska
    Academic press:
    Pathogens (year: 2020, volume: 9(6), pages: 451), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/pathogens9060451 – link to the publication

Articles in post-conference publications (8)

  1. Optymalizacja warunków qPCR dla oceny ekspresji genu IL-18 oraz białka (IL-18BP) i receptora ją wiążącego (IL-18R)

    Authors:
    S. Wawrocki, M. Druszczyńska
    Conference:
    III Ogólnopolska Konferencja Doktorantów Nauk o Życiu BioOpen 2017 (year: 2017, pages: 133), Publisher: Uniwersytet Łódzki
    Date:
    conference 11-12 maj
    Status:
    Published

  2. IL-18 and IFN-γ production in cultures of blood stimulated with Mycobacterium tuberculosis antigens

    Authors:
    S. Wawrocki, M. Włodarczyk, W. Rudnicka, M. Druszczyńska
    Conference:
    III Internationa Conference of Cell Biology (year: 2017, pages: 107), Publisher: Uniwersytet Jagieloński w Krakowie
    Date:
    conference 26-27 maj
    Status:
    Published

  3. IL-18 secretion in relation to IL-18 gene polymorphism in Mycobacterium tuberculosis-infected and uninfected individuals

    Authors:
    S. Wawrocki, M. Włodarczyk, W. Rudnicka, M. Druszczyńska
    Conference:
    7th International Weigl Conference (year: 2017, pages: 51), Publisher: 7th International Weigl Conference
    Date:
    conference 26-29 wrzesień
    Status:
    Published

  4. IL-18 and IL-18BP as markers of active and latent tuberculosis

    Authors:
    S. Wawrocki, J. Olszewicz, A. Lizińczyk, M.Druszczyńska
    Conference:
    IV Microbiology in Health Care and Environmental Protection - MIKROBIOT 2017 (year: 2017, pages: 38), Publisher: Polskie Towarzystwo Mikrobiologów
    Date:
    conference 19 - 21 wrzesień
    Status:
    Published

  5. Interleukina 18 (IL-18) oraz wiążące ją białko (IL-18BP) w odpowiedzi odpornościowej na prątki Mycobacterium tuberculosis

    Authors:
    S. Wawrocki, M. Włodarczyk, W. Rudnicka, M. Druszczyńska
    Conference:
    PTM wczoraj - dziś - jutro (year: 2017, pages: 61), Publisher: Uniwersytet Jagieloński w Krakowie
    Date:
    conference 22-23 wrzesień
    Status:
    Published

  6. Evaluation of IL-18 and interleukin-18 binding protein (IL-18BP) as possible biomarkers of latent Mycobacterium tuberculosis infection

    Authors:
    S. Wawrocki, M. Włodarczyk, W. Rudnicka, M. Druszczyńska
    Conference:
    SIMC Internationa Medical Congress of Silesia (year: 2017, pages: 40), Publisher: Uniwersytet Medyczny w Katowicach
    Date:
    conference 27-28 kwietnia
    Status:
    Published

  7. Association of cytokine gene polymorphisms with pulmonary tuberculosis in adults in Poland

    Authors:
    S. Wawrocki, M. Włodarczyk, G. Kielnierowski, L. Zhuravska, W. Rudnicka, M. Druszczyńska
    Conference:
    VIII Internationa Conference of Biotechnology Students (year: 2016, pages: 90), Publisher: Scientific Association of Biotechnology Students Gdańsk University of Technology
    Date:
    conference 25-27 listopad
    Status:
    Published

  8. IL-18 i IL-18BP w aktywnym zakażeniu Mycobacterium tuberculosis

    Authors:
    S. Wawrocki, A. Lizińczyk, J. Olszewicz, M. Włodarczyk, W. Rudnicka, M. Druszczyńska
    Conference:
    III Toruńskie Sympozjum Doktorantów Nauk Przyrodniczych (year: 2017, pages: 25), Publisher: Uniwersytetu Mikołaja Kopernika w Toruniu
    Date:
    conference 1-2 kwiecień
    Status:
    Published

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