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In vitro and in vivo investigations of the radiometals influence on the ability of CCK2R receptors imaging by the radiolabelled gastrin analogs.

2011/03/B/ST5/02734

Keywords

Descriptors

  • ST5_16: Chemia biologiczna
  • ST5_14: Chemia koordynacyjna
  • NZ7_14: Farmacja, farmakoterapia, farmakologia

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Narodowe Centrum Badań Jądrowych

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Renata Radosława Mikołajczak

Number of co-investigators in the project: 7

Call

OPUS 2 – announced on 2011-09-15

Amount awarded
636 080 PLN
Project start date
2012-08-30
Project end date
2015-08-29
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Klatki metaboliczne dla szczurów i myszy wraz z wymaganym osprzętem.
  2. Lampa chirurgiczna.
  3. Mata laboratoryjna antybakteryjna.
  4. Preparatywna kolumna chromatograficzna Luna 10 um C18(2) 100A 250x50 mm wraz z prekolumną.
  5. System klatek indywidualnie wentylowanych (IVC) z kompletnym systemem nawiewczo-wyciągowym i modułem transportowym.. Cost: 145 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. 177Lu Labelled Cyclic Minigastrin Analogues with Therapeutic Activity in CCK2R Expressing Tumours: Preclinical Evaluation of a Kit Formulation

    Authors:
    Ch. Rangger, M. Klingler, L. Balogh, Z. Pöstényi, A. Polyak, D. Pawlak, R. Mikołajczak, and E. von Guggenberg
    Academic press:
    Molecular Pharmaceutics (year: 2017, volume: 14(9), pages: 3045-3058), Publisher: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.7b00241 – link to the publication

  2. The radiometal makes a difference. Synthesis and preliminary characterization of DOTA-minigastrin analogue complexes with Ga, Lu and Y

    Authors:
    Michał Maurin, Piotr Garnuszek, Piotr Baran, Dariusz Pawlak, Renata Mikołajczak
    Academic press:
    Nuclear Medicine Review (year: 2015, volume: 2, pages: 51-55), Publisher: VIA MEDICA
    Status:
    Published
    DOI:
    10.5603/NMR.2015.0014 – link to the publication

  3. Structural studies on radiopharmaceutical DOTA-minigastrin analogue (CP04)complexes and their interaction with CCK2 receptor

    Authors:
    P.F. J. Lipiński, P. Garnuszek, M. Maurin, R. Stoll, N. Metzler-Nolte, A. Wodyński, J.Cz. Dobrowolski, M.K. Dudek, M. Orzełowska, R. Mikołajczak
    Academic press:
    European Journal of Nuclear Medicine and Molecular Imaging Research (year: 2018, volume: 8, pages: 46032), Publisher: Springer
    Status:
    Published
    DOI:
    10.1186/s13550-018-0387-3 – link to the publication

Articles in post-conference publications (7)

  1. Fizyko-chemiczna oraz radiochemiczna charakterystyka kompleksów analogu DOTA-Gastryny (CP04) z radiometalami

    Authors:
    M. Maurin, D. Pawlak, P. Garnuszek, A. Jaroń, N. Metzler-Nolte, R. Stoll, R. Mikołajczak
    Conference:
    XIV Naukowy Zjazd Polskiego Towarzystwa Medycyny Nuklearnej (year: 2014, pages: 1), Publisher: Via Medica
    Date:
    conference Lublin, Polska, 28- 30.05.2014
    Status:
    Published

  2. Preliminary results of microwave radiolabelling of DOTA-gastrin analogue with 90Y (abstrakt)

    Authors:
    D.Pawlak, M.Maurin, P.Garnuszek, R.Mikołajczak
    Conference:
    Annual Congress of the European Association of Nuclear Medicine, Lyon, France, (year: 2013, pages: 1), Publisher: EANM
    Date:
    conference 19-23.10.2013
    Status:
    Published

  3. Mikrofalowa radiosynteza analogów gastryny/cholecystokininy z Ga-68, Lu-177 i Y-90 (abstrakt)

    Authors:
    D. Pawlak, M. Maurin, P. Garnuszek, R. Mikołajczak
    Conference:
    II Ogólnopolska Konferencja Radiofarmaceutyczna, Łódź (year: 2013, pages: 1), Publisher: PTMN
    Date:
    conference 9-10.05.2013
    Status:
    Published

  4. Synthesis and Investigation of DOTA-Gastrin (CP04) Analogue Complexes with Yttrium, Lutetium and Gallium (abstract)

    Authors:
    P. Garnuszek, D.Pawlak, A.Jaroń, M. Maurin, R.Mikołajczak
    Conference:
    2nd International Symposium an Functional Metal Complexes that Bind to Biomolecules. Second Whole Action Meeting of the COST Action CM1105 (year: 2013, pages: 1), Publisher: materiały konferencyjne
    Date:
    conference Barcelona, Spain, 9-10.09.2013
    Status:
    Published

  5. Comparative evaluation of 68Ga, 90Y and 177Lu complexes of DOTA-minigastrin analogue (CP04)

    Authors:
    M. Maurin, P. Garnuszek, P. Baran, D. Pawlak, U. Karczmarczyk, R. Mikołajczak
    Conference:
    EMIM2015 European Molecular Imaging Meeting. 10th annual meeting of ESMI (year: 2015, pages: abstract No 213), Publisher: ESMI
    Date:
    conference 18.03.2015 - 20.03.2015
    Status:
    Published
    DOI:
    link to the publication

  6. HPLC and LC-MS investigations of CP04 complexes with radiometals

    Authors:
    M. Maurin, P. Baran, D. Pawlak, P. Garnuszek, R. Mikołajczak
    Conference:
    Annual Congress of the European Association of Nuclear Medicine (year: 2014, pages: 1), Publisher: Springer
    Date:
    conference Gothenburg, Sweden, 18-22.10.2014
    Status:
    Published

  7. Physico-chemical and radiochemical characteristic of DOTA-Gastrin (CP04)Analogue Complexes with radiometals

    Authors:
    M. Maurin, D. Pawlak, P. Garnuszek, A. Jaroń, R. Mikołajczak, N. Metzler-Nolte, R. Stoll
    Conference:
    17th European Symposium on Radiopharmacy and Radiopharmaceuticals (year: 2014, pages: 1), Publisher: Minerva Medica
    Date:
    conference Pamplona, Spain, 24-27.04.2014
    Status:
    Published

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