Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Structural studies based on low sequence similarity of G protein-coupled receptors activated by hormones and allosteric modulators

2012/07/D/NZ1/04244

Keywords:

membrane proteins G protein-coupled receptor homology modeling virtual screening molecular dynamics drug side effect allostery multiple sequence alignment sequence profile glycoprotein hormone receptors secretin-like receptors rhodopsin family GPR30 receptor activation agonism antagonism

Descriptors:

  • NZ1_4: Structural biology
  • NZ2_7: Bioinformatics
  • NZ1_3: Biophysics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Dorota Latek 

Number of co-investigators in the project: 3

Call: SONATA 4 - announced on 2012-09-15

Amount awarded: 491 250 PLN

Project start date (Y-m-d): 2013-07-16

Project end date (Y-m-d): 2019-01-15

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (3)
  1. A Molecular Dynamics Study of Vasoactive Intestinal Peptide Receptor 1 and the Basis of Its Therapeutic Antagonism
    Authors:
    Dorota Latek, Ingrid Langer,Krystiana A. Krzysko, Łukasz Charzewski
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(18), strony: 4348), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20184348 - link to the publication
  2. Rosetta Broker for membrane protein structure prediction: concentrative nucleoside transporter 3 and corticotropin-releasing factor receptor 1 test cases.
    Authors:
    Dorota Latek
    Academic press:
    BMC Structural Biology (rok: 2017, tom: 0,713888888888889, strony: N/A), Wydawca: BIOMED CENTRAL LTD
    Status:
    Published
    DOI:
    10.1186/s12900-017-0078-8 - link to the publication
  3. A hybrid approach to structure and function modeling of G protein-coupled receptors
    Authors:
    D. Latek, M. Bajda, S. Filipek
    Academic press:
    Journal of Chemical Information and Modeling (rok: 2016, tom: 56, strony: 630-641), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jcim.5b00451 - link to the publication
  4. GPCRM - a homology modeling web service with triple membrane-fitted quality assessment of GPCR models
    Authors:
    Przemysław Miszta, Paweł Pasznik, Jakub Jakowiecki, Agnieszka Sztyler, Dorota Latek, Sławomir Filipek
    Academic press:
    Nucleic Acids Research (rok: 2018, tom: 46, strony: W387–W395), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gky429 - link to the publication
  5. Drug-induced diabetes type 2: In silico study involving class B GPCRs
    Authors:
    Dorota Latek, Ewelina Rutkowska, Szymon Niewieczerzal, Judyta Cielecka-Piontek
    Academic press:
    PLOS ONE (rok: 2019, tom: 14(1), strony: e0208892), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0208892 - link to the publication
  6. Potential off-target effects of beta-blockers on gut hormone receptors: In silico study including GUT-DOCK—A web service for small-molecule docking
    Authors:
    Pawel Pasznik, Ewelina Rutkowska, Szymon Niewieczerzal, Judyta Cielecka-Piontek, Dorota Latek
    Academic press:
    PLOS ONE (rok: 2019, tom: 14(1), strony: e0210705), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Application of a membrane protein structure prediction web service GPCRM to a gastric inhibitory polypeptide receptor model
    Authors:
    Ewelina Rutkowska, Przemysław Miszta, Krzysztof Młynarczyk, Jakub Jakowiecki,Paweł Pasznik, Sławomir Filipek, Dorota Latek
    Conference:
    IWBBIO 2017 - 5th International Work-Conference on Bioinformatics and Biomedical Engineering (rok: 2017, ), Wydawca: Springer, Cham
    Data:
    konferencja 26-28 kwietnia 2017
    Status:
    Published
  2. Drug-induced diabetes risk reduction – in silico study involving gut hormone GPCR receptors
    Authors:
    Rutkowska Ewelina, Cielecka-Piontek Judyta, Niewieczerzal Szymon, Pasznik Paweł, Latek Dorota
    Conference:
    3rd Central European Biomedical Congress (rok: 2018, ), Wydawca: Instytut Farmakologii Polskiej Akademii Nauk w Krakowie, Collegium Medicum Uniwersytetu Jagiellońskiego
    Data:
    konferencja 15-18 września 2018
    Status:
    Published
  3. Gut hormone GPCRs as potential off-targets for beta-adrenoreceptor blocking agents
    Authors:
    Dorota Latek, Paweł Pasznik, Ewelina Rutkowska, Szymon Niewieczerzał, Judyta Cielecka-Piontek, Sławomir Filipek
    Conference:
    The Federation of the European Biochemical Societies (FEBS) Congress 2018 (rok: 2018, ), Wydawca: FEBS Press and John Wiley & Sons Ltd
    Data:
    konferencja 7-12 lipca 2018
    Status:
    Published

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