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Structural studies based on low sequence similarity of G protein-coupled receptors activated by hormones and allosteric modulators

2012/07/D/NZ1/04244

Keywords

Descriptors

  • NZ1_4: Biologia strukturalna
  • NZ2_7: Bioinformatyka
  • NZ1_3: Biofizyka

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Uniwersytet Warszawski, Wydział Chemii

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Dorota Latek

Number of co-investigators in the project: 3

Call

SONATA 4 – announced on 2012-09-15

Amount awarded
491 250 PLN
Project start date
2013-07-16
Project end date
2019-01-15
Project duration
66 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (6)

  1. GPCRM - a homology modeling web service with triple membrane-fitted quality assessment of GPCR models

    Authors:
    Przemysław Miszta, Paweł Pasznik, Jakub Jakowiecki, Agnieszka Sztyler, Dorota Latek, Sławomir Filipek
    Academic press:
    Nucleic Acids Research (year: 2018, volume: 46, pages: W387–W395), Publisher: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gky429 – link to the publication

  2. Drug-induced diabetes type 2: In silico study involving class B GPCRs

    Authors:
    Dorota Latek, Ewelina Rutkowska, Szymon Niewieczerzal, Judyta Cielecka-Piontek
    Academic press:
    PLOS ONE (year: 2019, volume: 14(1), pages: e0208892), Publisher: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0208892 – link to the publication

  3. Potential off-target effects of beta-blockers on gut hormone receptors: In silico study including GUT-DOCK—A web service for small-molecule docking

    Authors:
    Pawel Pasznik, Ewelina Rutkowska, Szymon Niewieczerzal, Judyta Cielecka-Piontek, Dorota Latek
    Academic press:
    PLOS ONE (year: 2019, volume: 14(1), pages: e0210705), Publisher: Public Library of Science
    Status:
    Published

  4. A hybrid approach to structure and function modeling of G protein-coupled receptors

    Authors:
    D. Latek, M. Bajda, S. Filipek
    Academic press:
    Journal of Chemical Information and Modeling (year: 2016, volume: 56, pages: 630-641), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jcim.5b00451 – link to the publication

  5. Rosetta Broker for membrane protein structure prediction: concentrative nucleoside transporter 3 and corticotropin-releasing factor receptor 1 test cases.

    Authors:
    Dorota Latek
    Academic press:
    BMC Structural Biology (year: 2017, volume: 0,713888888888889, pages: N/A), Publisher: BIOMED CENTRAL LTD
    Status:
    Published
    DOI:
    10.1186/s12900-017-0078-8 – link to the publication

  6. A Molecular Dynamics Study of Vasoactive Intestinal Peptide Receptor 1 and the Basis of Its Therapeutic Antagonism

    Authors:
    Dorota Latek, Ingrid Langer,Krystiana A. Krzysko, Łukasz Charzewski
    Academic press:
    International Journal of Molecular Sciences (year: 2019, volume: 20(18), pages: 4348), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20184348 – link to the publication

Articles in post-conference publications (3)

  1. Drug-induced diabetes risk reduction – in silico study involving gut hormone GPCR receptors

    Authors:
    Rutkowska Ewelina, Cielecka-Piontek Judyta, Niewieczerzal Szymon, Pasznik Paweł, Latek Dorota
    Conference:
    3rd Central European Biomedical Congress (year: 2018, pages: P.1-20), Publisher: Instytut Farmakologii Polskiej Akademii Nauk w Krakowie, Collegium Medicum Uniwersytetu Jagiellońskiego
    Date:
    conference 15-18 września 2018
    Status:
    Published

  2. Gut hormone GPCRs as potential off-targets for beta-adrenoreceptor blocking agents

    Authors:
    Dorota Latek, Paweł Pasznik, Ewelina Rutkowska, Szymon Niewieczerzał, Judyta Cielecka-Piontek, Sławomir Filipek
    Conference:
    The Federation of the European Biochemical Societies (FEBS) Congress 2018 (year: 2018, pages: 347-348), Publisher: FEBS Press and John Wiley & Sons Ltd
    Date:
    conference 7-12 lipca 2018
    Status:
    Published

  3. Application of a membrane protein structure prediction web service GPCRM to a gastric inhibitory polypeptide receptor model

    Authors:
    Ewelina Rutkowska, Przemysław Miszta, Krzysztof Młynarczyk, Jakub Jakowiecki,Paweł Pasznik, Sławomir Filipek, Dorota Latek
    Conference:
    IWBBIO 2017 - 5th International Work-Conference on Bioinformatics and Biomedical Engineering (year: 2017, pages: 151-162), Publisher: Springer, Cham
    Date:
    conference 26-28 kwietnia 2017
    Status:
    Published

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