Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Estrogen signaling in male gonad from birth to aging. Study of the molecular mechanisms of cellular processes in mammalian Leydig cells

2015/18/E/NZ4/00519

Keywords:

estrogens estrogen receptors Leydig cells bank vole boar

Descriptors:

  • NZ4_6: Endocrinology
  • NZ4_3: Comparative physiology
  • NZ4_2: Physiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Małgorzata Kotula-Balak 

Number of co-investigators in the project: 10

Call: SONATA BIS 5 - announced on 2015-06-15

Amount awarded: 991 199 PLN

Project start date (Y-m-d): 2016-05-13

Project end date (Y-m-d): 2019-04-12

Project duration:: 35 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Automatyczny licznik komórek (17 000 PLN)
  2. Próżniowy koncentrator próbek (65 000 PLN)
  3. Zestaw komputerowy.
  4. Czytnik płytek z luminometrem (65 000 PLN)
  5. Laptop z oprogramowaniem (3 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Telocytes are localized to testis of the bank vole (Myodes glareolus) and are affected by lighting conditions and G-coupled membrane estrogen receptor (GPER) signaling.
    Authors:
    Milon A, Pawlicki P, Rak A, Mlyczynska E, Płachno BJ, Tworzydlo W, Gorowska-Wojtowicz E, Bilinska B, Kotula-Balak M.
    Academic press:
    General and Comparative Endocrinology (rok: 2019, tom: 15;271, strony: 39-48.), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.021 - link to the publication
  2. Effect of estrogen-related receptor silencing on miRNA protein machinery expression, global methylation, and deacetylation in bank vole (Myodes glareolus) and mouse tumor Leydig cells.
    Authors:
    Milon A, Knapczyk-Stwora K, Pawlicki P, Duliban M, Gorowska-Wojtowicz E, Kotula-Balak M, Bilinska B.
    Academic press:
    Theriogenology (rok: 2019, tom: 139, strony: 178-190), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.theriogenology.2019.07.030 - link to the publication
  3. Mouse testicular transcriptome after modulation of non-canonical oestrogen receptor activity.
    Authors:
    Duliban M, Gurgul A, Szmatola T, Pawlicki P, Milon A, Arent ZJ, Grzmil P, Kotula-Balak M, Bilinska B.
    Academic press:
    Reproduction Fertility and Development (rok: 2020, tom: 32, strony: 903-913.), Wydawca: CSIRO Publishing
    Status:
    Published
    DOI:
    10.1071/RD20025. - link to the publication
  4. Does signaling of estrogen-related receptors affect structure and function of bank vole Leydig cells?
    Authors:
    Pawlicki P, Milon A, Zarzycka M, Galas J, Tworzydlo W, Kaminska A, Pardyak L, Lesniak K, Pacwa A, Bilinska B, Gorowska-Wojtowicz E, Kotula-Balak M.
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2017, tom: 68, strony: 459-476), Wydawca: POLISH PHYSIOLOGICAL SOCIETY
    Status:
    Published
    DOI:
    brak - link to the publication
  5. Do G-protein coupled estrogen receptor and bisphenol A analogs influence on Leydig cell epigenetic regulation in immature boar testis ex vivo?
    Authors:
    Pawlicki P, Duliban M, Tuz R, Ptak A, Milon A, Gorowska-Wojtowicz E, Tworzydlo W, Płachno BJ, Bilinska B, Knapczyk-Stwora K, Kotula-Balak M.
    Academic press:
    Animal Reproduction Scences (rok: 2019, tom: 207, strony: 21-35), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.anireprosci.2019.06.006. - link to the publication
  6. Chlorinated biphenyls effect on estrogen-related receptor expression, steroid secretion, mitochondria ultrastructure but not on mitochondrial membrane potential in Leydig cells.
    Authors:
    Milon A, Opydo-Chanek M, Tworzydlo W, Galas J, Pardyak L, Kaminska A, Ptak A, Kotula-Balak M.
    Academic press:
    Cell and Tissue Research (rok: 2017, tom: 369, strony: 429-444), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00441-017-2596-x. - link to the publication
  7. Insights into the role of estrogen-related receptors α, β and γ in tumor Leydig cells.
    Authors:
    Kotula-Balak M, Milon A, Pawlicki P, Opydo-Chanek M, Pacwa A, Lesniak K, Sekula M, Zarzycka M, Bubka M, Tworzydlo W, Bilinska B, Hejmej A.
    Academic press:
    Tissue and Cell (rok: 2018, tom: 52, strony: 78-91), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tice.2018.04.003 - link to the publication
  8. Primary and tumor mouse Leydig cells exposed to polychlorinated naphthalenes mixture: Effect on estrogen related-receptors expression, intracellular calcium level and sex hormones secretion.
    Authors:
    Pardyak L, Kaminska A, Galas J, Ptak A, Bilinska B, Kotula-Balak M.
    Academic press:
    Tissue and Cell (rok: 2016, tom: 48, strony: 432-441), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tice.2016.08.004. - link to the publication
  9. Telocytes in the mouse testicular interstitium: implications of G-protein-coupled estrogen receptor (GPER) and estrogen-related receptor (ERR) in the regulation of mouse testicular interstitial cells.
    Authors:
    Pawlicki P, Hejmej A, Milon A, Lustofin K, Płachno BJ, Tworzydlo W, Gorowska-Wojtowicz E, Pawlicka B, Kotula-Balak M, Bilinska B.
    Academic press:
    Protoplasma (rok: 2019, tom: 256, strony: 393-408.), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00709-018-1305-2. - link to the publication
  10. The role of G-protein-coupled membrane estrogen receptor in mouse Leydig cell function-in vivo and in vitro evaluation.
    Authors:
    Kotula-Balak M, Pawlicki P, Milon A, Tworzydlo W, Sekula M, Pacwa A, Gorowska-Wojtowicz E, Bilinska B, Pawlicka B, Wiater J, Zarzycka M, Galas J.
    Academic press:
    Cell Tissue Research (rok: 2018, tom: 374, strony: 389-412), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00441-018-2861-7 - link to the publication

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