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Conjugated linoleic acid (CLA)-induced transcriptional activation of PPAR-an investigation of molecular machanisms of putative anticancer action of fatty acids of CLA-enriched egg yolks

2011/03/B/NZ9/01423

Keywords

Descriptors

  • NZ9_7: Naukowe podstawy żywienia i badania żywności
  • NZ7_12: Prewencja chorób człowieka
  • NZ1_1: Biologia molekularna

Panel

NZ9 – Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution

Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Wydział Technologii Żywności

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Teresa Leszczyńska

Number of co-investigators in the project: 10

Call

OPUS 2 – announced on 2011-09-15

Amount awarded
755 460 PLN
Project start date
2012-08-06
Project end date
2016-08-05
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Inkubator CO2. Cost: 25 000 PLN
  2. Komora do badań PCR.
  3. Komora laminarna typu Biohazard. Cost: 45 000 PLN
  4. Komora laminarna z modułem do hodowli w warunkach atmosfery CO2/O2.
  5. Mikroskop odwrówcony.
  6. Termocykler Real-Time PCR. Cost: 155 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Effect of dietary conjugated linoleic acid (CLA) and thermal processing on fatty acid composition of enriched chicken meat

    Authors:
    Franczyk-Zarów, Magdalena; Koronowicz, Aneta; Szymczyk, Beata; Biezanowska-Kopec , Renata; Leszczynska, Teresa
    Academic press:
    Journal of Animal and Feed Sciences (year: 2017, volume: 26(3), pages: 236–246), Publisher: The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland
    Status:
    Published
    DOI:
    10.22358/jafs/76184/2017 – link to the publication

  2. Fatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation

    Authors:
    Aneta A. Koronowicz, Paula Banks, Dominik Domagała, Adam Master, Teresa Leszczyńska, Ewelina Piasna, Mariola Marynowska and Piotr Laidler
    Academic press:
    Genes & Nutrition (year: 2016, volume: 0,473611111111111, pages: brak), Publisher: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12263-016-0537-z – link to the publication

  3. Dietary conjugated linoleic acid affects blood parameters, liver morphology and expression of selected hepatic genes in laying hens

    Authors:
    Aneta A. Koronowicz, Paula Banks, Beata Szymczyk, Teresa Leszczyńska, Adam Master, Ewelina Piasna, Wojciech Szczepański, Dominik Domagała, Aneta Kopeć, Ewa Piątkowska and Piotr Laidler
    Academic press:
    British Poultry Science (year: 2016, volume: 57, pages: ISSN: 0007-1668 (Print) 1466-1799 (Online)), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/00071668.2016.1192280 – link to the publication

  4. Fatty acids of CLA-enriched egg yolks can induce transcriptional activation of PPAR receptors in MCF-7 breast cancer cells

    Authors:
    Aneta A. Koronowicz Paula Banks, Adam Master Dominik Domagała Ewelina Piasna-Słupecka, Mariola Drozdowska, Elhbieta Sikora and Piotr Laidler
    Academic press:
    PPAR Research (year: 2017, volume: 2017, pages: 12 page), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/2865283 – link to the publication

Articles in post-conference publications (3)

  1. Effect of fatty acid extracts from cla-enriched and non-enriched egg yolks on MCF-7 transcriptome profile

    Authors:
    Aneta Koronowicz; Paula Banks; Dominik Domagała; Adam Master; Piotr Laidler; Teresa Leszczynska.
    Conference:
    12th European Nutrition Conference (FENS) (year: 2015, pages: 67(suppl 1):1–601; 395-396), Publisher: Karger; Annals of Nutrition and Metabolism
    Date:
    conference October 20–23, 2015
    Status:
    Published

  2. Antagonistic effect of Cla isomers on expression of selected cell cycle genes in cancer cells

    Authors:
    Aneta Koronowicz; Elzbeta Sikora; Adam Master; Dominik Domagała; Piotr Laidler; Teresa Leszczyńska
    Conference:
    12th European Nutrition Conference (FENS) (year: 2015, pages: 67(suppl 1):393), Publisher: Karger; Annals of Nutrition & Metabolism
    Date:
    conference October 20–23
    Status:
    Published

  3. Dietary conjugated linoleic acid upregulates detoxification genes in non-alcoholic fatty liver of isa brown hens

    Authors:
    Teresa Leszczynska; Aneta Koronowicz; Wojciech Szczepanski; Paula Banks; Ewelina Piasna; Ewa Piątkowska; Aneta Kopeć; Katarzyna Zajac; Dominik Domagala; Piotr Laidler
    Conference:
    12th European Nutrition Conference (FENS) (year: 2015, pages: 67(suppl 1):1–601; 275-276), Publisher: Karger; Annals of Nutrition and Metabolism
    Date:
    conference Berlin; October 20–23
    Status:
    Published

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