Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Conjugated linoleic acid (CLA)-induced transcriptional activation of PPAR-an investigation of molecular machanisms of putative anticancer action of fatty acids of CLA-enriched egg yolks

2011/03/B/NZ9/01423

Keywords:

Conjugated linoleic acid (CLA) anticancer properties of CLA cis9,trans11-CLA isomer trans10,cis12-CLA isomer peroxisome proliferator-activated receptors (PPARs) transcriptional activation of ligand-dependent transcription factors PPAR-dependent regulation of gene expression saRNA (RNAa) siRNA (RNAi) tumors cell lines agonist/antagonist of PPAR melanoma breast cancer prostate cancer nutrigenomics nutrients enriched food nutraceutics

Descriptors:

  • NZ9_7: Nutrition and food sciences
  • NZ7_12: Prevention of human diseases
  • NZ1_1: Molecular biology

Panel:

NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution :

Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Wydział Technologii Żywności

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Teresa Leszczyńska 

Number of co-investigators in the project: 10

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 755 460 PLN

Project start date (Y-m-d): 2012-08-06

Project end date (Y-m-d): 2016-08-05

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator CO2 (25 000 PLN)
  2. Komora do badań PCR.
  3. Mikroskop odwrówcony.
  4. Komora laminarna z modułem do hodowli w warunkach atmosfery CO2/O2.
  5. Termocykler Real-Time PCR (155 000 PLN)
  6. Komora laminarna typu Biohazard (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (3)
  1. Fatty acids of CLA-enriched egg yolks can induce transcriptional activation of PPAR receptors in MCF-7 breast cancer cells
    Authors:
    Aneta A. Koronowicz Paula Banks, Adam Master Dominik Domagała Ewelina Piasna-Słupecka, Mariola Drozdowska, Elhbieta Sikora and Piotr Laidler
    Academic press:
    PPAR Research (rok: 2017, tom: 2017, strony: 12 page), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/2865283 - link to the publication
  2. Dietary conjugated linoleic acid affects blood parameters, liver morphology and expression of selected hepatic genes in laying hens
    Authors:
    Aneta A. Koronowicz, Paula Banks, Beata Szymczyk, Teresa Leszczyńska, Adam Master, Ewelina Piasna, Wojciech Szczepański, Dominik Domagała, Aneta Kopeć, Ewa Piątkowska and Piotr Laidler
    Academic press:
    British Poultry Science (rok: 2016, tom: 57, strony: ISSN: 0007-1668 (Print) 1466-1799 (Online)), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/00071668.2016.1192280 - link to the publication
  3. PPAR A and G receptors expressed from vectors containing CMV promoter can regulate self-transcription in the presence of fatty acids from CLA-enriched egg yolks - a new model for studies on PPAR ligands
    Authors:
    Koronowicz Aneta A., Master Adam, Banks Paula, Piasna-Słupecka Ewelina, Domagała Dominik, Drozdowska Mariola and Leszczyńska Teresa
    Academic press:
    Plos One (tom: brak, strony: brak), Wydawca: Public Library of Science
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. Effect of dietary conjugated linoleic acid (CLA) and thermal processing on fatty acid composition of enriched chicken meat
    Authors:
    Franczyk-Zarów, Magdalena; Koronowicz, Aneta; Szymczyk, Beata; Biezanowska-Kopec , Renata; Leszczynska, Teresa
    Academic press:
    Journal of Animal and Feed Sciences (rok: 2017, tom: 26(3), strony: 236–246), Wydawca: The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jabłonna, Poland
    Status:
    Published
    DOI:
    10.22358/jafs/76184/2017 - link to the publication
  5. Fatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation
    Authors:
    Aneta A. Koronowicz, Paula Banks, Dominik Domagała, Adam Master, Teresa Leszczyńska, Ewelina Piasna, Mariola Marynowska and Piotr Laidler
    Academic press:
    Genes & Nutrition (rok: 2016, tom: 0,473611111111111, strony: brak), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12263-016-0537-z - link to the publication
  6. Effect of Fatty Acid extract from CLA-enriched egg yolks on cellular stress response and apoptosis in MCF-7 breast cancer cells
    Authors:
    Aneta Agnieszka Koronowicz, Mariola Drozdowska, Paula Banks, Ewelina Piasna-Słupecka, Dominik Domagała, Adam Master, Teresa Leszczyńska
    Academic press:
    Journal of Functional Foods , Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Antagonistic effect of Cla isomers on expression of selected cell cycle genes in cancer cells
    Authors:
    Aneta Koronowicz; Elzbeta Sikora; Adam Master; Dominik Domagała; Piotr Laidler; Teresa Leszczyńska
    Conference:
    12th European Nutrition Conference (FENS) (rok: 2015, ), Wydawca: Karger; Annals of Nutrition & Metabolism
    Data:
    konferencja October 20–23
    Status:
    Published
  2. Dietary conjugated linoleic acid upregulates detoxification genes in non-alcoholic fatty liver of isa brown hens
    Authors:
    Teresa Leszczynska; Aneta Koronowicz; Wojciech Szczepanski; Paula Banks; Ewelina Piasna; Ewa Piątkowska; Aneta Kopeć; Katarzyna Zajac; Dominik Domagala; Piotr Laidler
    Conference:
    12th European Nutrition Conference (FENS) (rok: 2015, ), Wydawca: Karger; Annals of Nutrition and Metabolism
    Data:
    konferencja Berlin; October 20–23
    Status:
    Published
  3. Effect of fatty acid extracts from cla-enriched and non-enriched egg yolks on MCF-7 transcriptome profile
    Authors:
    Aneta Koronowicz; Paula Banks; Dominik Domagała; Adam Master; Piotr Laidler; Teresa Leszczynska.
    Conference:
    12th European Nutrition Conference (FENS) (rok: 2015, ), Wydawca: Karger; Annals of Nutrition and Metabolism
    Data:
    konferencja October 20–23, 2015
    Status:
    Published

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