Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular characterization of Chd64 and FKBP39 proteins, key components of multiprotein complex mediating juvenile hormone- and/or ecdysone induced biological signals

2012/05/B/NZ1/00659

Keywords:

intrinsically disordered protein Chd64 FKBP39 juvenile hormone ecdysone juvenile hormone receptor,

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Wrocławska, Wydział Chemiczny

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Ożyhar 

Number of co-investigators in the project: 7

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 837 560 PLN

Project start date (Y-m-d): 2013-02-21

Project end date (Y-m-d): 2016-08-20

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Ultrazamrażarka -80oC (35 000 PLN)
  2. Inkubator z wytrząsarką Multitron II (73 000 PLN)
  3. Spektrofotometr NanoDrop 2000 (63 000 PLN)
  4. Thermomixer (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Book publications / chapters in book publications (3)
  1. Nucleoplasmin-like domain of FKBP39 from Drosophila melanogaster forms a tetras with partly disordered tentacle-like C-terminal segments
    Authors:
    Małgorzta Kozłowska, Aneta Tarczewska, Michał Jakób, Dominika Bystranowska, Michał Taube, Maciej Kozak, Mariusz Czarnocki-Cieciurs, Andrzej Dziembowski, Marek Orłowski, Katarzyna Tkocz, Andrzej Ożyhar
    Academic press:
    Scientific reports (rok: 2017, tom: 7:40405, strony: 45305), Wydawca: Nature publishing Group
    Status:
    Published
    DOI:
    10.1038/srep40405 - link to the publication
  2. Homodimerization Propensity of the Intrinsically Disordered N-terminal Domain of Ultrascpiracle from Aedes aegypti
    Authors:
    JOann Pieprzyk, Agnieszka Zbela, Michał Jakób, Andrzej Ożyhar, Marek Orłowski
    Academic press:
    Biochimica et Biophysica Acta / Proteins and Proteomics (rok: 2014, tom: 1844, strony: 1153-1166), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbapap.2014.03.010 - link to the publication
  3. Insight into the Unfolding Properties of Chd64, a Small, Single Domain Protein with a Globular core and disordered Tails
    Authors:
    Aneta Tarczewska, Malgorzata Kozłowska Piotr Dobryszycki, Magdalena Kaus-Drobek, Michał Dadlez, Andrzej Ożyhar
    Academic press:
    PLoS ONE (rok: 2015, tom: 10(9), strony: e0137074), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0137074 - link to the publication
  4. The Molecular Basis of Conformational Instability of the Ecdysone Receptor DNA Binding Domain Studied by in Silico and In vitro Experiments
    Authors:
    Agnieszka Szamborska-Gbur, Grzegorz Rymarczyk, Marek Orłowski, Tomasz Kuzynowski, Michał Jakób, Agnieszk Dziedzic-Letka, Andrzej Górecki, Piotr Dobryszycki, Andrzej Ożyhar
    Academic press:
    PLOS One (rok: 2014, tom: 9, strony: e86052), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0086052 - link to the publication
  5. Molecular determinants of Drosophila immunophilin FKBP nuclear localization
    Authors:
    Marek Orłowski, Katarzyna Popławska, Aleksandra Szczygieł-Sommer, Anna Więch, Mirosław Zarębski, Aneta Tarczewska, Jurek Dobrucki, Andrzej Ożyhar
    Academic press:
    Biological Chemistry (rok: 2018, tom: 399(5), strony: 467-484), Wydawca: De gruyter
    Status:
    Published
    DOI:
    10.1515/hsz-2017-0251 - link to the publication
  6. Calponin-like Chd64 is partly disorderd
    Authors:
    Małgorzata Kozłowska, Aneta Tarczewska, Michał Jakób, Kamil Szpotkowski, Magdalena Wojtas, Grzegorz Rymarczyk, Andrzej Ożyhar
    Academic press:
    PLOS One (rok: 2014, tom: 9, strony: e9689), Wydawca: Public Library of Science (PLOS)
    Status:
    Published
    DOI:
    10.1371/journal.pone.0096809 - link to the publication
  1. Structural Analyses of Ordered and Disordered Regions on Ecdysteroid Receptor
    Authors:
    Marek Orłowski, Piotr Dobryszycki, Anna Zoglowek, Joann Pieprzyk, Katarzyna Bielska, Beata Greb-Markiewicz, Małgorzata Kozłowska, Aneta Tarczewska, Andrzej Ożyhar
    Book:
    Nuclear Receptors: From Structure to the Clinic (rok: 2015, tom: -, strony: 93-203), Wydawca: Springer
    Status:
    Published
  2. Preparation of expression constructs containing cDNA coding for TcFKBP39 protein from Tribolium castaneum
    Authors:
    Aneta Tarczewska, Małgorzata Kozłowska
    Book:
    Interdyscyplinarność badań naukowych 2014 (rok: 2014, tom: -, strony: 104-108), Wydawca: Politechnika Wrocławska
    Status:
    Published
    DOI:
    link to the publication
  3. Synthesis, purification and in silico analysis of immunophilin FKBP39 from Drosophila melanogaster
    Authors:
    Małgorzata Kozłowska, Aneta Tarczewska
    Book:
    Interdyscyplinarność badań naukowych 2014 (rok: 2014, tom: -, strony: 66-70), Wydawca: Politechnika Wrocławska
    Status:
    Published
    DOI:
    link to the publication

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