Projects funded by the NCN

"I like to move it, move it" – molecular dynamics-driven optimization of ligand residence time as an opportunity to impr...

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr hab. Sabina Marta Podlewska

Instytut Farmakologii PAN

Optimization of coarse-grained molecular dynamics simulations for tunnel exploration of large proteins with buried activ...

Call: PRELUDIUM 22 , Panel: NZ2

Principal investigator: Nishita Mandal

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

New applications of non-conventional nonempirical methodologies for the analysis of catalytic and inhibitory properties ...

Call: OPUS 25 , Panel: ST4

Principal investigator: dr Edyta Dyguda-Kazimierowicz

Politechnika Wrocławska

Study of ligand binding and activation processes of formyl, opioid and cannabinoid G-protein-coupled receptors

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Sławomir Hubert Filipek

Uniwersytet Warszawski, Wydział Chemii

Psychedelic-induced molecular changes in the brain

Call: SONATINA 7 , Panel: NZ2

Principal investigator: dr Dominik Łukasz Cysewski

Uniwersytet Medyczny w Białymstoku

Development of novel anti-cancer immunotherapy against mesothelioma comprising of oncolytic adenovirus vectors armed wit...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Łukasz Kuryk

Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny (NIZP - PZH)

Palladium-catalyzed cascades for the rapid and enantioselective construction of polycyclic scaffolds of alkaloids and ps...

Call: OPUS 24 , Panel: ST4

Principal investigator: dr hab. Rafał Antoni Loska

Instytut Chemii Organicznej Polska Akademia Nauk

Effect of lignans on biomass and toxigenic profile of Fusarium graminearum.

Call: OPUS 2 , Panel: NZ9

Principal investigator: dr hab. Tomasz Kulik

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Kształtowania Środowiska i Rolnictwa

Thermodynamic contribution of halogen bonds in protein-ligand systems. Design, synthesis, and thermodynamic studies of m...

Call: PRELUDIUM 21 , Panel: ST4

Principal investigator: dr Sławomir Jan Kasperowicz

Instytut Biochemii i Biofizyki PAN

Metallocarbaporphyrinoids as ligands in monomeric and oligomeric complexes. Synthesis, interactions, and catalysis.

Call: OPUS 23 , Panel: ST4

Principal investigator: prof. Piotr Jan Chmielewski

Uniwersytet Wrocławski, Wydział Chemii

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Anna Szczepańska

Instytut Farmakologii PAN

Crystallographic analysis of RNA-ligand complexes. Towards rational design oflead compounds for development of therapies...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Ludmiła Kiliszek

Instytut Chemii Bioorganicznej PAN

Allosteric and allosteric-orthosteric bitopic ligands of histamine receptor H4 as a way to increase selectivity and bias...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Sławomir Hubert Filipek

Uniwersytet Warszawski, Wydział Chemii

Metallosupramolecular architectures based on flexidentate pyridyl-β-diketonate ligands - synthesis, properties and catal...

Call: PRELUDIUM 21 , Panel: ST4

Principal investigator: Gracjan Piotr Kurpik

Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum Zaawansowanych Technologii

Novel tricyclic glycomimetics as DC-SIGN receptor ligands.

Call: OPUS 22 , Panel: ST4

Principal investigator: dr Mykhaylo Potopnyk

Instytut Chemii Organicznej Polska Akademia Nauk

Development of the knowledge on the role of GPR18 ligands as a microglia-targeted strategy in the regulation of neuroinf...

Call: SONATA 17 , Panel: NZ3

Principal investigator: dr Ewelina Barbara Honkisz-Orzechowska

Uniwersytet Jagielloński, Collegium Medicum

Targeting cell surface proteoglycans with high affinity multimeric ligands and their cytotoxic conjugates – towards prec...

Call: OPUS 22 , Panel: NZ1

Principal investigator: dr hab. Łukasz Opaliński

Uniwersytet Wrocławski, Wydział Biotechnologii

Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

Uniwersytet Jagielloński, Collegium Medicum

Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

Call: OPUS 22 (LAP) , Panel: NZ7

Principal investigator: prof. Kinga Aleksandra Sałat

Uniwersytet Jagielloński, Collegium Medicum

Reversible modulation of G-quadruplex functions using photoresponsive ligands - in vitro and cellular studies

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Marta Maria Dudek

Politechnika Wrocławska

The interplay of neurochemistry and cancer biology: in the search for novel glioblastoma multiforme therapy among dopami...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Katarzyna Maria Kucwaj-Brysz

Uniwersytet Jagielloński, Collegium Medicum

True Bioisosteres - Structural and Thermodynamic Classification of Molecular Fragments for Ligand Design

Call: SONATA BIS 11 , Panel: ST4

Principal investigator: dr Maura Dagmara Malińska

Uniwersytet Warszawski, Wydział Chemii

Deciphering the molecular mechanism of activity switch of the ubiquitin ligase CHIP

Call: PRELUDIUM 20 , Panel: NZ1

Principal investigator: Pankaj Thapa

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Combating addiction by targeting α3β4*-nicotinic acetylcholine receptors

Call: OPUS 21 , Panel: NZ7

Principal investigator: dr Ákos Nemecz

Uniwersytet Mikołaja Kopernika, Wydział Nauk Biologicznych i Weterynaryjnych

Impact of hydrological regimes on the quantitive and qualitative optical properties of dissolved organic matter in West ...

Call: OPUS 21 , Panel: ST10

Principal investigator: dr Monika Dorota Zabłocka

Instytut Oceanologii PAN

Survey of Chinese Communist Party provincial-level committees: a quantitative approach

Call: PRELUDIUM 20 , Panel: HS5

Principal investigator: Adrian Krystian Brona

Uniwersytet Jagielloński, Wydział Studiów Międzynarodowych i Politycznych

Antiviral strategies targeting RNA: Triplex forming peptide nucleic acids (PNA) and their small molecule conjugates spec...

Call: OPUS 21 , Panel: NZ1

Principal investigator: prof. Elżbieta Beata Kierzek

Instytut Chemii Bioorganicznej PAN

Living on the edge: evolutionary adaptation of substrate-recruiting subunits of the cullin-RING ubiquitin ligase complex...

Call: PRELUDIUM 20 , Panel: NZ1

Principal investigator: Natalia Anna Szulc

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

First-in-class dual biased agonists of serotonin 5-HT1A and dopamine D2 receptors – an innovative approach in the search...

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Marcin Roman Kołaczkowski

Uniwersytet Jagielloński, Collegium Medicum

The interactome of Upf1 (Nam7) ubiquitin ligase - deciphering thesubstrates and novel biological functions

Call: PRELUDIUM 20 , Panel: NZ2

Principal investigator: Natalia Joanna Łazarewicz

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Wood from pine family (Pinaceae) native to Poland as a potent source of pharmacologically active lignans

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Andrzej Patyra

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Advanced coordination materials designed on the basis of functional silsesquioxanes

Call: OPUS 21 , Panel: ST5

Principal investigator: dr hab. Beata Dudziec

Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum Zaawansowanych Technologii

Assessing protein-ligand complexes with ML/DL models trained on molecular dynamics-based descriptors.

Call: OPUS 20 , Panel: ST4

Principal investigator: dr hab. Paweł Aleksander Siedlecki

Instytut Biochemii i Biofizyki PAN

AXL receptor signaling in cancer cell growth and drug resistance

Call: OPUS 20 , Panel: NZ3

Principal investigator: prof. Marta Elżbieta Miączyńska

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Photodynamics of metal complexes with 2,6-bis(thiazol-2-yl)pyridine derivatives functionalized by aryls and N-donors as ...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Anna Maria Maroń

UNIWERSYTET ŚLĄSKI, Wydział Nauk Ścisłych i Technicznych

Multifunctional character of copper(II) macrocyclic complexes – utilization in atom transfer radical polymerization (ATR...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Adam Paweł Gorczyński

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

The new methodology for better understanding of ligand-RNA interactions.

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr Filip Artur Stefaniak

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Silsesquioxanes as Multifunctional Ligands in Coordination Chemistry and Nano-Building Blocks for Hybrid Materials

Call: OPUS 20 , Panel: ST4

Principal investigator: dr hab. Łukasz John

Uniwersytet Wrocławski, Wydział Chemii

New therapies of opioid use disorder

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr Wojciech Barnaba Solecki

Uniwersytet Jagielloński, Wydział Zarządzania i Komunikacji Społecznej

Anti-cancer strategy based on the induced G-quadruplex formation. Structural and biological properties of ligand-RNA/mRN...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Dorota Gudanis-Sobocińska

Instytut Chemii Bioorganicznej PAN

Input of the structure of influenza A virus RNA on regulation of virus proliferation. High throughput screening of small...

Call: OPUS 20 , Panel: NZ1

Principal investigator: prof. Elżbieta Beata Kierzek

Instytut Chemii Bioorganicznej PAN

The influence of environment on biomolecular function, structure and interactions.

Call: SONATA BIS 10 , Panel: ST4

Principal investigator: dr hab. Piotr Mikołaj Setny

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of gliobl...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: dr Przemysław Patryk Zaręba

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

Investigation into the mechanism of regulation of nicotinic acetylcholine receptors

Call: POLS , Panel: NZ3

Principal investigator: dr Ákos Nemecz

Uniwersytet Mikołaja Kopernika, Wydział Nauk Biologicznych i Weterynaryjnych

New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Anna Marta Pasieka

Uniwersytet Jagielloński, Collegium Medicum

Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Alicja Aleksandra Gawalska

Uniwersytet Jagielloński, Collegium Medicum

Interconversions of supramolecular architectures based on Schiff base ligands and transition metal ions as potential pro...

Call: PRELUDIUM 19 , Panel: ST4

Principal investigator: Martyna Szymańska

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Structure-function relationship in fibroblast growth factor signaling

Call: CEUS-UNISONO , Panel: NZ3

Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

Uniwersytet Wrocławski, Wydział Biotechnologii

Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Andrzej Mikołaj Pilc

Instytut Farmakologii PAN

Dual histamine H3 and sigma-1 receptor ligands as novel pharmacological tools in the treatment of central nervous system...

Call: SONATINA 4 , Panel: NZ7

Principal investigator: Katarzyna Anna Szczepańska

Instytut Farmakologii PAN