Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Reversible modification of enzyme activity and substrate specificity by engineering of the ligand exchange pathways

2015/18/M/NZ1/00427

Keywords:

cysteine switch enzyme activity and selectivity regulation access pathway modification ligands transport

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_9: Biotechnology
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Śląska, Centrum Biotechnologii

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Artur Góra 

Number of co-investigators in the project: 9

Call: HARMONIA 7 - announced on 2015-06-15

Amount awarded: 538 080 PLN

Project start date (Y-m-d): 2016-05-23

Project end date (Y-m-d): 2020-05-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (4)
  1. AQUA-DUCT: Analysis of Molecular Dynamics Simulations of Macromolecules with the use of Molecular Probes [Article v1. 0]
    Authors:
    K Mitusińska, A Raczyńska, P Wojsa, M Bzówka, A Góra
    Academic press:
    Living Journal of Computational Molecular Science (rok: 2021, tom: 2, strony: 21383), Wydawca: University of Colorado Boulder
    Status:
    Published
    DOI:
    10.33011/livecoms.2.1.21383 - link to the publication
  2. Structural and Evolutionary Analysis Indicate That the SARS-CoV-2 Mpro Is a Challenging Target for Small-Molecule Inhibitor Design
    Authors:
    Maria Bzówka, Karolina Mitusińska, Agata Raczyńska, Aleksandra Samol, Jack A. Tuszyński, Artur Góra
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 3099), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21093099 - link to the publication
  3. AQUA-DUCT 1.0: structural and functional analysis of macromolecules from an intramolecular voids perspective
    Authors:
    Tomasz Magdziarz, Karolina Mitusinska, Maria Bzo´ wka, Agata Raczynska, Agnieszka Stanczak, Michał Banas, Weronika Bagrowska and Artur Go´ ra
    Academic press:
    Bioinformatics (rok: 2019, tom: unknown, strony: 45294), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/bioinformatics/btz946 - link to the publication
  4. Simple Selection Procedure to Distinguish between Static and Flexible Loops
    Authors:
    Karolina Mitusińska, Tomasz Skalski, Artur Góra
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 2293), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072293 - link to the publication
  5. Applications of water molecules for analysis of macromolecule properties
    Authors:
    Karolina Mitusińska, Agata Raczyńska, Maria Bzówka, Weronika Bagrowska, Artur Góra
    Academic press:
    Computational and Structural Biotechnology Journal (rok: 2020, tom: 18, strony: 355-365), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2020.02.001 - link to the publication
  6. Engineering a de Novo Transport Tunnel
    Authors:
    J. Brezovsky, P. Babkova, O. Degtjarik, A. Fortova, A. Gora, I. Iermak, P. Rezacova, P. Dvorak, I. K. Smatanova, Z. Prokop, R. Chaloupkova, and J. Damborsky
    Academic press:
    ACS Catalysis (rok: 2016, tom: 6, strony: 7597–7610), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acscatal.6b02081 - link to the publication
  1. Hot spot identification by ligand-protein surface interactions mapping – in silico study
    Authors:
    A. Stanczak, T. Magdziarz, A. Raczynska, A. Góra
    Conference:
    18th European Congress On Biotechnology (rok: 2018, ), Wydawca: Elsevier - New Biotechnology
    Data:
    konferencja 1-4 lipca
    Status:
    Published
  2. Identification and verification of the role of distal surface amino acids for LinB enzyme activity
    Authors:
    Patryk Kapica, Katarzyna Papaj, Anna Byczek, Mariusz Nowak, Agnieszka Stańczak, Artur Góra
    Conference:
    XXIII Gliwice Scientific Meetings 2019 (rok: 2019, ), Wydawca: Association for the Support of Cancer Research
    Data:
    konferencja 43791
    Status:
    Published
  3. STRUCTURAL ASPECTS OF SELECTIVE INHIBITION OF INDUCIBLE NITRIC OXIDE SYNTHASE
    Authors:
    Maria Bzówka, Artur Góra , Jan Víteček, Lukáš Kubala, Jiří Damborský
    Conference:
    XXI st Gliwice Scientific Meetings 2017 (rok: 2017, ), Wydawca: Association for the Support of Cancer Research
    Data:
    konferencja 17-18.11
    Status:
    Published
  4. SUBSTRATES TRAPPING BY PROTEIN SURFACE – IN SILICO STUDY
    Authors:
    Agnieszka Stańczak, Artur Góra
    Conference:
    XXI st Gliwice Scientific Meetings 2017 (rok: 2017, ), Wydawca: Association for the Support of Cancer Research
    Data:
    konferencja 17-18.11
    Status:
    Published

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