Projects funded by the NCN
Study of mechanism of proteolysis and a selective ligand binding to gamma-secretase complex
2016/23/B/NZ2/03247
Keywords:
gamma-secretase complex proteolysis beta-amyloid
Descriptors:
- NZ2_8: Computational biology
- NZ2_10: Biological systems analysis, modelling and simulation
Panel:
NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology
Host institution :
Uniwersytet Warszawski, Wydział Chemii
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: OPUS 12 - announced on 2016-09-15
Amount awarded: 695 500 PLN
Project start date (Y-m-d): 2017-07-18
Project end date (Y-m-d): 2021-07-17
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Program LigandScout (15 000 PLN)
- Platforma programowa Schrodinger (3 szt.) (30 000 PLN)
- roczna licencja na program ICM-Pro/VLS (31 415 PLN)
- EndNote.
- stacja robocza (2 szt.) (90 000 PLN)
- program ICM-Pro (3 szt.) (21 000 PLN)
- mała stacja robocza (7 179 PLN)
Information in the final report
- Publication in academic press/journals (2)
- Unfolding of β-amyloid substrates in the active site of γ-secretaseAuthors:Jakub Jakowiecki, Urszula Orzeł, Krzysztof Młynarczyk, Sławomir FilipekAcademic press:Biomolecules (rok: 2021, tom: 11, strony: ), Wydawca: MDPIStatus:SubmittedDOI:brak - link to the publication
- The role of cholesterol in amyloidogenic substrate binding to the γ-secretase complexAuthors:U. Orzeł, J. Jakowiecki, K. Młynarczyk, S. FilipekAcademic press:Biomolecules (rok: 2021, tom: 11, strony: 935), Wydawca: MDPIStatus:PublishedDOI:10.3390/biom11070935 - link to the publication