Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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In vivo and in vitro structure of influenza virus RNA. The structural determinants behind the inhibition of influenza virus proliferation with modified antisense oligonucleotides, siRNAs and small molecule ligands

2015/19/B/NZ1/02803

Keywords:

RNA influenza virus RNA structure antisense oligonucleotides siRNA small molecule ligands

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Elżbieta Kierzek 

Number of co-investigators in the project: 6

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 985 100 PLN

Project start date (Y-m-d): 2016-06-20

Project end date (Y-m-d): 2020-06-19

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do elektroforezy pionowej z chłodzeniem i akcesoriami (8 100 PLN)
  2. aparat do analiz typu Western Blot z osprzętem i zestawem początkowym (18 000 PLN)
  3. Zasilacz wysokonapięciowy do elektroforezy (9 500 PLN)
  4. Aspirator próżniowy z końcówkami do pracy w komorze laminarnej (14 700 PLN)
  5. aparat gradientowy PCR.
  6. Cieplarka z obiegiem CO2 (34 500 PLN)
  7. Zestaw komputerowy (komputer, monitor i drukarka laserowa) (8 000 PLN)
  8. zamrażarka niskotemperaturowa (-80C) z wyposażeniem (35 500 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Modified RNA triplexes: Thermodynamics, structure and biological potential.
    Authors:
    M. Szabat, E. Kierzek, R. Kierzek
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 13023), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-31387-5 - link to the publication
  2. Influenza virus segment 5 (+)RNA - secondary structure and new targets for antiviral strategies
    Authors:
    M. Soszynska-Jozwiak, P. Michalak, W. N. Moss, R. Kierzek, J. Kesy, E. Kierzek
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 15041), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-017-15317-5 - link to the publication
  3. A Short Chemically Modified dsRNA-Binding PNA (dbPNA) Inhibits Influenza Viral Replication by Targeting Viral RNA Panhandle Structure
    Authors:
    J. Kesy, K.M. Patil, S.R. Kumar, Z.Y. Shu, H.Y. Yong, L. Zimmermann, A.A.L. Ong, D.F.K. Toh, M.S. Krishna, L.X. Yang, J.L. Decout, D.H. Luo, M. Prabakaran, G. Chen, E. Kierzek
    Academic press:
    Bioconjugate Chemistry (rok: 2019, tom: 30, strony: 931-943), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.bioconjchem.9b00039 - link to the publication
  4. RNA Secondary Structure Motifs of the Influenza A Virus as Targets for siRNA-Mediated RNA Interference
    Authors:
    J. Piasecka, E. Lenartowicz, M. Soszynska-Jozwiak, B. Szutkowska, R. Kierzek, E. Kierzek
    Academic press:
    Molecular Therapy - Nucleic Acids (rok: 2020, tom: 19, strony: 627–642), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.omtn.2019.12.018 - link to the publication
  5. Secondary structure of the segment 5 genomic RNA of influenza A virus and its application for designing antisense oligonucleotides
    Authors:
    P. Michalak, M. Soszynska-Jozwiak, E. Biala, W.N. Moss, J. Kesy, B. Szutkowska, E. Lenartowicz, R. Kierzek, E. Kierzek
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 3801), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-40443-7 - link to the publication
  6. Secondary structure model of the naked segment 7 influenza A virus genomic RNA
    Authors:
    Ruszkowska A., Lenartowicz E., Moss W. N., Kierzek R., Kierzek E
    Academic press:
    Biochemical Journal (rok: 2017, tom: 473, strony: 4327-4348), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BCJ20160651 - link to the publication

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