Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Development of an NK1 receptor homology model based on the data concerning interspecies differences in ligand binding.

2016/23/D/NZ7/03636

Keywords:

NK1 receptor tachykinins substance P homology modelling

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST4_13: Solid-state chemistry, surface physicochemistry
  • ST5_16:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Piotr Lipiński 

Number of co-investigators in the project: 4

Call: SONATA 12 - announced on 2016-09-15

Amount awarded: 499 850 PLN

Project start date (Y-m-d): 2017-07-04

Project end date (Y-m-d): 2021-07-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Antiproliferative effects of [D-Pro2, D-Trp7,9]-Substance P and aprepitant on several cancer cell lines and their selectivity in comparison to normal cells
    Authors:
    Matalińska, J; Świć, A, Lipiński, P.F.J., Misicka A.
    Academic press:
    Folia Neuropathologica (rok: 2020, tom: 58, strony: 237-244), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/fn.2020.100066 - link to the publication
  2. Search for N-acylhydrazone-based NK1R ligands with cytotoxic activity
    Authors:
    Katarzyna Kosińska, Joanna Matalińska, Jolanta Dyniewicz, Jolanta Zaborniak, Aleksandra Misicka, Piotr F. J. Lipiński
    Academic press:
    Pharmaceuticals , Wydawca: MDPI
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. In Vivo, In Vitro and In Silico Studies of the Hybrid Compound AA3266, an Opioid Agonist/NK1R Antagonist with Selective Cytotoxicity
    Authors:
    Matalińska, J; Lipiński, P.F.J.; Kosson, P.; Kosińska, K.; Misicka, A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 20, strony: 7738), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21207738 - link to the publication
  4. The solid state VCD of a novel N-acylhydrazone trifluoroacetate
    Authors:
    Joanna Rode, Krzysztof Lyczko, Katarzyna Kosińska, Joanna Matalińska, Jolanta Dyniewicz, Aleksandra Misicka, Jan Cz. Dobrowolski, Piotr F.J. Lipiński
    Academic press:
    Specrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication

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