Projects funded by the NCN

Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

Synthetic epidermal growth factor receptor inhibitor conjugated with nobel metal nanoparticles as a potential drug for t...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Shaoshan Mai

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: Magdalena Maria Żarnik

Uniwersytet Jagielloński, Wydział Chemii

Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short pept...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Ewa Maria Surmiak

Uniwersytet Jagielloński, Wydział Chemii

DNA polymerase θ as a novel therapeutic target in personalized anticancer therapy

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Tomasz Adam Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Structure optimization of the PD-1/PD-L1 inhibitors based on the terphenyl scaffold

Call: PRELUDIUM 19 , Panel: ST4

Principal investigator: dr Damian Muszak

Uniwersytet Jagielloński, Wydział Chemii

Inhalable polymeric delivery systems of antibiotics and quorum sensing inhibitors for the treatment of respiratory infec...

Call: OPUS 18 , Panel: ST5

Principal investigator: prof. Elżbieta Pamuła

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Inżynierii Materiałowej i Ceramiki

The use of olaparib and ATR / CHK1 kinase inhibitors as a targeted anti-cancer therapy based on synthetic lethality

Call: SONATA BIS 9 , Panel: NZ7

Principal investigator: dr hab. Aneta Katarzyna Rogalska

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Gold and silver nanoparticles as carriers for delivery of 5' end mRNA cap analogues with potential therapeutical applica...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Marzena Jankowska-Anyszka

Uniwersytet Warszawski, Wydział Chemii

Search for structure-antimicrobial activity correlation for selected boraheterocycles

Call: OPUS 16 , Panel: ST5

Principal investigator: prof. Sergiusz Mariusz Luliński

Politechnika Warszawska, Wydział Chemiczny

De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhib...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Łukasz Berlicki

Politechnika Wrocławska, Wydział Chemiczny

CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

Call: OPUS 15 , Panel: NZ6

Principal investigator: dr hab. Marcin Sieńczyk

Politechnika Wrocławska

Organometallic compounds as selective inhibitors of selected multidrug resistance proteins

Call: OPUS 15 , Panel: ST5

Principal investigator: dr hab. Damian Nestor Plażuk

Uniwersytet Łódzki, Wydział Chemii

Toward understanding allosteric regulation of the proteasome activity

Call: OPUS 1 , Panel: ST5

Principal investigator: dr hab. Elżbieta Jankowska

Uniwersytet Gdański, Wydział Chemii

Polymeric inhibitors of Zika virus

Call: OPUS 14 , Panel: ST5

Principal investigator: prof. Maria Nowakowska

Uniwersytet Jagielloński, Wydział Chemii

Inhibitors of BTLA-HVEM complex formation as potential targets for cancer immunotheraphy

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Marta Marcelina Spodzieja

Uniwersytet Gdański, Wydział Chemii

Small-molecule inhibitors for characterization of the interaction between extracellular domains of Programmed Cell Death...

Call: MAESTRO 9 , Panel: ST5

Principal investigator: prof. Tadeusz Andrzej Holak

Uniwersytet Jagielloński, Wydział Chemii

Aminophosphonates bearing fluorine atoms as inhibitors odf aminopeptideses and their potential application for determina...

Call: HARMONIA 9 , Panel: ST5

Principal investigator: prof. Paweł Kazimierz Kafarski

Politechnika Wrocławska

Optical and time-resolved spectroscopy for hypothesis veryfication of the conducting by mTS the reductive reaction with ...

Call: PRELUDIUM 13 , Panel: NZ1

Principal investigator: Małgorzata Katarzyna Prokopowicz

Uniwersytet Warszawski, Wydział Fizyki

Synthesis of 2-phosphonocarboxylates as potential covalent inhibitors of Rab geranylgeranyl transferase

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Joanna Natalia Małolepsza

Politechnika Łódzka, Wydział Chemiczny

Allosteric inhibitors of proteasome - optimization of the structure of PR39 analogs in order to achieve greater efficien...

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Małgorzata Giżyńska

Uniwersytet Gdański, Wydział Chemii

Electrochemical analysis of the corrosion process of Al2Cu intermetallic phase in the acidic solutions, in the presence ...

Call: SONATA 12 , Panel: ST5

Principal investigator: dr Przemysław Szczepan Kwolek

Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Budowy Maszyn i Lotnictwa

Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

Call: SONATA 12 , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Precision medicine-guided synthetic lethality targeting DNA repair to eradicate solid tumors

Call: HARMONIA 8 , Panel: NZ7

Principal investigator: dr hab. Tomasz Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Synthesis and biological evaluation of novel, drug-like multifunctional ligands, as potential anti-Alzheimer's agents ta...

Call: PRELUDIUM 11 , Panel: NZ7

Principal investigator: Dawid Marcin Panek

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

3D structure-based search for selective inhibitor of thymidylate synthase of nematodes, a potential drug in chemotherapy...

Call: OPUS 1 , Panel: NZ6

Principal investigator: prof. Wojciech Krzysztof Rode

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Molecular aspects of interference with the thymidylate synthase-catalyzed reaction mechanism by the slow-binding inhibit...

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Wojciech Krzysztof Rode

Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Chemiczny

Anticancer activity of novel tubulin polymerization inhibitors obtained by the chemical modification of colchicine

Call: OPUS 11 , Panel: ST5

Principal investigator: dr hab. Adam Włodzimierz Huczyński

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Molecular mechanism of action of substances decreasing the synthesis of glycosaminoglycans in terms of their potential u...

Call: OPUS 1 , Panel: NZ1

Principal investigator: dr hab. Magdalena Angelina Gabig-Cimińska

Uniwersytet Gdański, Wydział Biologii

Discovery and development of small-molecule inhibitors of USP2 for targeted, non-genotoxic therapy of cancer

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Tadeusz Andrzej Holak

Uniwersytet Jagielloński, Wydział Chemii

Design, synthesis and biological evaluation of the new steroid sulfatase (STS) inhibitors based on sulfamate analogs con...

Call: PRELUDIUM 10 , Panel: NZ7

Principal investigator: Mateusz Daśko

Politechnika Gdańska, Wydział Chemiczny

Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese...

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Maria Wanda Bretner

Politechnika Warszawska, Wydział Chemiczny

New MOF compounds as degradable nanocontainers of tyrosine kinases inhibitors in novel anti-cancer therapy

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Artur Piotr Terzyk

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Chemii