Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Design, synthesis and in vitro and in vivo studies of anticancer potential of phosphonic and phosphinic analogs of sulforaphane and their mercapturic derivatives with potential ability to inhibit histone deacylase

2011/03/B/ST5/01058

Keywords:

isothiocyantes organic synthesis antiproliferative activity in vitro studies in vivo studies

Descriptors:

  • ST5_23:
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

POLITECHNIKA ŁÓDZKA, Wydział Chemiczny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tadeusz Gajda 

Number of co-investigators in the project: 11

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 1 203 300 PLN

Project start date (Y-m-d): 2012-09-05

Project end date (Y-m-d): 2016-08-04

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Nanodrop (spektrofotometr mierzący stężenie DNA, RNA oraz białek w małych objętościach) (56 000 PLN)
  2. Mikrofalowy system do przeprowadzania syntez f-my Candela Sp. z o.o (130 000 PLN)
  3. Wyparka do odparowywania próżniowego wraz z membranową, chemoodporną pompą próżniową f-my Donserw (20 000 PLN)
  4. Liofilizator (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Is it Possible to induce the "Spontaneous Regression" of Cancer? A Mechanism of Activation for the Innate Immune Response
    Authors:
    Oleksyszyn, J.
    Academic press:
    Journal of Nutritional Biology (rok: 2016, tom: 2, strony: 44-48), Wydawca: Gratisoa
    Status:
    Published
    DOI:
    10.18314/jnb.v2i1.50 - link to the publication
  2. Synthesis and biological activity of diisothiocyanate-derived mercapturic acids
    Authors:
    R. Grzywa, Ł. Winiarski, M. Psurski, A. Rudnicka, J. Wietrzyk, T. Gajda, J. Oleksyszyn
    Academic press:
    Bioorg. Med. Chem. Lett. (rok: 2016, tom: 26, strony: 667-671), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2015.11.045 - link to the publication
  3. Cell viability of glioblastoma stem cells is effectively reduced by diisothocyanate-derived mercapturic acids
    Authors:
    Cwiklowska, K.; Westhoff, M.; Freisinger, S.; Dwucet, A.; Halatsch, M.; Knippschild, U.; Debatin, K.; Schirmbeck, R.; Winiarski, Ł.; Oleksyszyn, J.; Rainer Wirtza, C.; Burster, T.
    Academic press:
    Anti-Cancer Agents in Medicinal Chemistry (rok: 2016, ), Wydawca: Bentham Science Publ. LTD
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. Cancer – Could it be cured? A Spontaneous Regression of Cancer, Cancer Energy Metabolism, Hyperglycemia-Hypoglycemia, Metformin, Warburg and Crabtree Effects nd a New Perspective in Cancer Treatment
    Authors:
    Oleksyszyn, J., Psurski, M., Wietrzyk, J.
    Academic press:
    J. Cancer Sci. Ther. (rok: 2014, tom: 6, strony: 56-61), Wydawca: OMCS Group
    Status:
    Published
    DOI:
    10.4172/1948-5956.1000249 - link to the publication
  5. Microwave-assisted synthesis of dialkyl ω-azidoalkylphosphonates
    Authors:
    Ł. Janczewski,; A. Gajda; J. Braszczyńska; T. Gajda
    Academic press:
    Synth. Commun. (rok: 2016, tom: 46, strony: 1625-1633), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/00397911.2016.1221114 - link to the publication

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