Projects funded by the NCN

Dual-acting 5-HT6/5-HT7 receptor antagonists: exploring beneficial effects for the treatment of neurodegenerative disord...

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Michał Kamiński

Uniwersytet Jagielloński

Positioning the aryl hydrocarbon receptor (AhR) as a new target for pharmacotherapy of sporadic Alzheimer disease: verif...

Call: OPUS 28 , Panel: NZ7

Principal investigator: prof. Małgorzata Kajta

Instytut Farmakologii PAN

Analysis of the effects of proteotoxic stress on cholesterol homeostasis and its associations with cardiovascular diseas...

Call: OPUS 28 , Panel: NZ5

Principal investigator: prof. Wiesława Elżbieta Widłak

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

The first antibody-drug conjugates for Alzheimer's disease therapy

Call: SONATA BIS 14 , Panel: NZ5

Principal investigator: dr hab. Marcin Łukasz Poręba

Politechnika Wrocławska

Autophagy stimulation by genistein to cure Alzheimer disease: mechanisms and effects investigated using genetic (cellula...

Call: OPUS 27 , Panel: NZ2

Principal investigator: prof. Grzegorz Władysław Węgrzyn

Uniwersytet Gdański

Effect of phosphorylation of Aβ peptides on the redox activity oftheir copper complexes and aggregation in the context o...

Call: SONATA 19 , Panel: ST4

Principal investigator: dr Nina Ewa Wezynfeld

Politechnika Warszawska, Wydział Chemiczny

First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Jadwiga Handzlik

Uniwersytet Jagielloński, Collegium Medicum

ROS-Scavenging Magnetic Nanozymes with Remote Activation for Alzheimer Disease

Call: M-ERA.NET 3 Call 2023 , Panel: NZ5

Principal investigator: dr hab. Anna Ludwika Haduch

Instytut Farmakologii PAN

Deciphering the Chemoproteomics and Chemotranscriptomics of Anti-Alzheimer Drugs for Novel Druggable Target Identificati...

Call: JPND Call 2023 , Panel: NZ5

Principal investigator: prof. Krzysztof Sobczak

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

(Micro)RNA and informatics approaches for diagnosis, prognosis and treatment of Alzheimer's disease and Dementia

Call: JPND Call 2023 , Panel: NZ3

Principal investigator: dr hab. Agnieszka Fiszer

Instytut Chemii Bioorganicznej PAN

Local molecular changes in amyloid-β altered by green tea's active compounds

Call: PRELUDIUM 22 , Panel: ST4

Principal investigator: Michał Andrzej Czaja

Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Blood plasma microRNA profile as a basis for detecting Alzheimer's disease and dementia risk in pre-symptomatic individu...

Call: OPUS 24 , Panel: NZ7

Principal investigator: prof. Urszula Wojda

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Study of the regenerative potential of Stem Cells from Human Exfoliated Deciduous teeth (SHED) in Alzheimer's disease

Call: POLONEZ BIS 3 , Panel: NZ3

Principal investigator: dr Leila Elyasi

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Defining (sex and age) cell-specific epigenetic mechanisms underlying EnvironmentalEnrichment/Exercise as non-pharmacolo...

Call: JPND Call 2022 , Panel: NZ2

Principal investigator: dr hab. Bartosz Zbigniew Wilczyński

Uniwersytet Warszawski

Selective modulation of PPARγ signaling as a new therapeutic strategy for Alzheimer's disease

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Karolina Barbara Przepiórska-Drońska

Instytut Farmakologii PAN

Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Kinga Maria Czarnota-Łydka

Uniwersytet Jagielloński, Collegium Medicum

Effects of activation of cholinergic, noradrenergic, and serotonergic systems on respiratory impairment in Alzheimer's d...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Kaczyńska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Development of the knowledge on the role of GPR18 ligands as a microglia-targeted strategy in the regulation of neuroinf...

Call: SONATA 17 , Panel: NZ3

Principal investigator: dr Ewelina Barbara Honkisz-Orzechowska

Uniwersytet Jagielloński, Collegium Medicum

Bleomycin hydrolase, homocysteine metabolism, epigenetic regulation of mTOR signalling, autophagy, and Alzheimer's disea...

Call: OPUS 22 , Panel: NZ4

Principal investigator: dr hab. Joanna Perła-Kaján

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Biotechnologii

New approach to the treatment of Alzheimer's disease targetingresolution of inflammation and modulation of biomechanical...

Call: OPUS 22 , Panel: NZ4

Principal investigator: prof. Agnieszka Basta-Kaim

Instytut Farmakologii PAN

Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

Call: OPUS 22 (LAP) , Panel: NZ7

Principal investigator: prof. Kinga Aleksandra Sałat

Uniwersytet Jagielloński, Collegium Medicum

Presymptomatic synaptic disorders in Alzheimer's disease

Call: JPco-fuND2 Call 2021 , Panel: NZ5

Principal investigator: dr Michalina Maria Wężyk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Potential neuroprotective properties of modulators of sphingosine-1-phosphate (S1P) receptors (fingolimod and siponimod)...

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: Iga Wieczorek

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Selective inhibitors of γ-aminobutyric acid (GABA) transporter subtype 3 (GAT3) as a new pharmacological tools and a cha...

Call: OPUS 21 , Panel: NZ7

Principal investigator: dr Dawid Marcin Panek

Uniwersytet Jagielloński, Collegium Medicum

Spectroelectrochemistry of Alzheimer's disease - a study of a new potential therapeutic molecule

Call: SONATINA 5 , Panel: ST4

Principal investigator: dr Magdalena Zofia Wiloch

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Selective activation of non-nuclear Estrogen Receptor signaling with PaPE-1 as a novel therapeutic approach for sporadic...

Call: OPUS 20 , Panel: NZ7

Principal investigator: prof. Małgorzata Kajta

Instytut Farmakologii PAN

Direct monitoring of the local dynamic rearrangement of the Alzheimer's peptides secondary structure upon the aggregatio...

Call: OPUS 19 , Panel: ST4

Principal investigator: dr hab. Ewelina Lipiec

Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Deficits of spontaneous retrieval in older individuals with periodontitis: search for early cognitive dementia markers

Call: PRELUDIUM 19 , Panel: HS6

Principal investigator: Michał Marian Wereszczyński

Uniwersytet Jagielloński, Wydział Filozoficzny

New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Anna Marta Pasieka

Uniwersytet Jagielloński, Collegium Medicum

Towards innovative strategy for treatment of Alzheimer's Disease via dual inhibition of receptor 5-HT6 and kinase CDK5.

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Sylwia Sudoł-Tałaj

Uniwersytet Jagielloński, Collegium Medicum

Cortical reinstatement in health and Alzheimer's' disease: a direct approach to testing the hippocampal memory indexing ...

Call: CEUS-UNISONO , Panel: NZ4

Principal investigator: dr Rafał Czajkowski

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Structural studies of the influence of selected surfactants on the amyloidogenic properties of various forms of beta pep...

Call: ETIUDA 8 , Panel: ST4

Principal investigator: Michalina Maria Wilkowska

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Fizyki

Novel role of peroxisome proliferator-activated receptor α in the regulationof amyloid β peptide metabolism and mitochon...

Call: PRELUDIUM 18 , Panel: NZ4

Principal investigator: dr Sylwia Żulińska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Effect of drugs, mitochondrial proteins and miRNA biomarkers of neurodegenerative diseases on dynamics and conversion of...

Call: SONATA BIS 9 , Panel: ST4

Principal investigator: dr hab. Sławomir Roman Jakieła

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

Multitarget approach to break the vicious circle of tau pathology and neuroinflammation in Alzheimer's disease: developm...

Call: SONATA BIS 9 , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński, Collegium Medicum

Alzheimer's disease as a co-morbidity of chronic periodontitis with Porphyromonas gingivalis as a causative link between...

Call: JPND2019 , Panel: NZ1

Principal investigator: prof. Jan Stanisław Potempa

Uniwersytet Jagielloński

Executive attention, genetic risk of Alzheimer's disease and cingulate cortex: an EEG and fMRI study

Call: PRELUDIUM 16 , Panel: HS6

Principal investigator: Patrycja Joanna Dzianok

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

The role of BET family proteins in microglia-dependent neurodegeneration; relevance to Alzheimer's disease

Call: OPUS 16 , Panel: NZ4

Principal investigator: dr hab. Grzegorz Arkadiusz Czapski

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Novel hybrid 5-HT6 serotonin receptor and SERT transporter ligands as a therapeutic perspective of behavioural and cogni...

Call: SONATA 14 , Panel: NZ7

Principal investigator: dr Agata Siwek

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

MicroRNAs in blood as biomarkers for Alzheimer's disease: molecular signature for personalized therapy

Call: OPUS 15 , Panel: NZ7

Principal investigator: prof. Urszula Wojda

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Western diet as a potent risk factor of Alzheimer's disease progression: influence of a long-term Western diet feeding o...

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: Angelika Elżbieta Więckowska-Gacek

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Role of Pon1 in Alzheimer Disease.

Call: OPUS 15 , Panel: NZ4

Principal investigator: prof. Hieronim Jakubowski

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Bioinżynierii

Structures of oligomers of amyloid beta peptides: Multiscale molecular simulations.

Call: PRELUDIUM 14 , Panel: NZ1

Principal investigator: Dinh Quoc Huy Pham

Instytut Fizyki PAN

HCN channel functions in EEG synchronization and memory formation in a rat model of AD

Call: SONATA 13 , Panel: NZ4

Principal investigator: dr Paulina Dominika Kaźmierska-Grębowska

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Anilide derivatives of long-chain cyclic amines as multifunctional serotonin receptors ligands and phosphodiesterase 7 i...

Call: PRELUDIUM 13 , Panel: NZ7

Principal investigator: dr Agnieszka Wioleta Jankowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Interaction of membrane-active peptides with model cell membrane and their role in a drug delivery system. Electrochemic...

Call: OPUS 12 , Panel: ST4

Principal investigator: dr Piotr Rafał Pięta

Instytut Chemii Fizycznej Polskiej Akademii Nauk

New perspective in Alzheimer's disease therapy - multifunctional histamine H3 receptor ligands?

Call: OPUS 12 , Panel: NZ7

Principal investigator: dr hab. Dorota Łażewska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Mechanism of substrate recognition and binding by gamma-secretase on the example of the amyloid precursor protein

Call: PRELUDIUM 12 , Panel: ST4

Principal investigator: Łukasz Piotr Nierzwicki

Politechnika Gdańska, Wydział Chemiczny

Biased inverse agonists of 5-HT6 receptor and dual 5-HT6/MAO-B inhibitors - in search for new therapeutic approaches for...

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Paweł Maria Zajdel

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Synthesis and biological evaluation of novel, drug-like multifunctional ligands, as potential anti-Alzheimer's agents ta...

Call: PRELUDIUM 11 , Panel: NZ7

Principal investigator: Dawid Marcin Panek

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny