Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Search for early molecular mechanisms and markers of preclinical stage of sporadic form of Alzheimer's disease (SAD) in comparative studies in APPswDI/NOS2-/- mice with induced insulin resistance and in patients with diagnosed sporadic Alzheimer's disease (SAD).

2014/15/D/NZ4/04361

Keywords:

Alzheimer's Disease (AD) amyloid beta protein tau protein type 2 diabetes (T2DM) advanced glycation end products (AGEs) inflammatory processes oxidative stress cell cycle p21 protein apoptosis

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_11: Metabolism

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Mietelska-Porowska 

Number of co-investigators in the project: 5

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 711 000 PLN

Project start date (Y-m-d): 2015-07-21

Project end date (Y-m-d): 2019-07-20

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Homogenizator/dysocjator, pompa perfuzyjna, sterylizator do narzędzi chirurgicznych (50 000 PLN)
  2. Analizator biochemiczny do krwi Fuji DRI-CHEM NX500.
  3. Analizator hematologiczny do krwi Scil Vet ABC.

Information in the final report

  • Publication in academic press/journals (4)
  1. Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet
    Authors:
    Mietelska-Porowska Anna, Domańska Justyna, Want Andrew, Więckowska-Gacek Angelika, Chutorański Dominik, Koperski Maciej, Wojda Urszula.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(9), strony: 4744), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23094744 - link to the publication
  2. Western diet induces impairment of liver-brain axis accelerating neuroinflammation and amyloid pathology in Alzheimer's disease.
    Authors:
    Angelika Więckowska-Gacek, Anna Mietelska-Porowska, Dominik Chutorański, Małgorzata Wydrych, Jan Długosz and Urszula Wojda
    Academic press:
    Frontiers in Aging Neuroscience (rok: 2021, tom: 13, strony: 654509), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnagi.2021.654509 - link to the publication
  3. T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer's Disease: Potential Pools of New Biomarkers
    Authors:
    Mietelska-Porowska Anna, Wojda Urszula
    Academic press:
    Journal of Immunology Research (rok: 2017, tom: 2017, strony: 45308), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2017/4626540 - link to the publication
  4. Western diet as a trigger of Alzheimer's disease: from metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration.
    Authors:
    Angelika Więckowska-Gacek, Anna Mietelska-Porowska, Małgorzata Wydrych, Urszula Wojda.
    Academic press:
    Ageing Research Reviews (rok: 2021, tom: 70, strony: 101397), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2021.101397 - link to the publication

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