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Western diet as a potent risk factor of Alzheimer's disease progression: influence of a long-term Western diet feeding on activation of resident microglia and monocyte-derived macrophages in early stage of Alzheimer's disease development

2018/29/N/NZ7/01724

Keywords

Descriptors

  • NZ7_12: Prewencja chorób człowieka
  • NZ4_7: Neurofizjologia
  • NZ4_11: Metabolizm

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Angelika Elżbieta Więckowska-Gacek

Number of co-investigators in the project: 2

Call

PRELUDIUM 15 – announced on 2018-03-15

Amount awarded
140 000 PLN
Project start date
2019-01-21
Project end date
2023-01-20
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (2)

  1. Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

    Authors:
    Angelika Więckowska-Gacek, Anna Mietelska-Porowska, Małgorzata Wydrych, Urszula Wojda
    Academic press:
    Ageing Research Reviews (year: 2021, volume: 70, pages: 46045), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2021.101397 – link to the publication

  2. Western Diet Induces Impairment of Liver-Brain Axis Accelerating Neuroinflammation and Amyloid Pathology in Alzheimer's Disease

    Authors:
    Angelika Wiȩckowska-Gacek, Anna Mietelska-Porowska, Dominik Chutorański, Małgorzata Wydrych, Jan Długosz, Urszula Wojda
    Academic press:
    Frontiers in Aging Neuroscience (year: 2021, volume: brak, pages: brak), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fnagi.2021.654509. – link to the publication

Articles in post-conference publications (3)

  1. Western diet- from metabolic duisturbances to acceleration of glia activation and development of Alzheimer's disease

    Authors:
    Więckowska A, Mietelska-Porowska A., Wydrych M., Długosz J., Chutorański D., Wojda U.
    Conference:
    14th International Congress of the Polish Neuroscience Society, Katowice, Poland (year: 2019, pages: XLV), Publisher: Acta Neurobiologiae Experimentalis, volume 79, Abstr P1.12
    Date:
    conference 43706
    Status:
    Published

  2. WESTERN DIET AS A TRIGGER OF ALZHEIMER'S DISEASE: FROM METABOLIC SYNDROME TO NEURODEGENERATION

    Authors:
    Angelika Więckowska-Gacek, Angelika Więckowska-Gacek, Andrew Want, Dominik Chutorański, Urszula Wojda
    Conference:
    12th Neuronus 2022 Neuroscience Forum (year: 2022, pages: XV), Publisher: Acta Neurobiologiae Experimentalis, volume 82, Supplement
    Date:
    conference 15-17 października 2022
    Status:
    Published

  3. WESTERN DIET – FROM MICROGLIA DYSFUNCTION TO THE ACCELERATION OF ALZHEIMER'S DISEASE PATHOLOGY

    Authors:
    Angelika Więckowska-Gacek, Anna Mietelska‑Porowska, Justyna Domańska, Urszula Wojda
    Conference:
    12th Neuronus 2022 Neuroscience Forum (year: 2022, pages: XLIX), Publisher: Acta Neurobiologiae Experimentalis, volume 82, Supplement
    Date:
    conference 15-17 października 2022
    Status:
    Published

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