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Information on the principal investigator and host institution

Information of the project and the call

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Bleomycin hydrolase, homocysteine metabolism, epigenetic regulation of mTOR signalling, autophagy, and Alzheimer's disease

2021/43/B/NZ4/00339

Keywords:

BLMH homocysteine thiolactone Phf8 Alzheimer's disease Blmh-/-3xTg-AD mice mouse neroblastoma cells N2A-APPSwe amyloid beta phospho-Tau

Descriptors:

  • NZ4_004:
  • NZ4_011:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Biotechnologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Perła-Kaján 

Number of co-investigators in the project: 7

Call: OPUS 22 - announced on 2021-09-15

Amount awarded: 3 513 600 PLN

Project start date (Y-m-d): 2022-10-03

Project end date (Y-m-d): 2026-10-02

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  1. Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1-dependent epigenetic regulation of mTOR in cystathionine β-synthase-deficient mice
    Authors:
    Witucki Ł, Jakubowski H
    Academic press:
    J Inherit Metab Dis (rok: 2023, tom: 46, strony: 1114-1130), Wydawca: Willey
    Status:
    Published
    DOI:
    10.1002/jimd.12661 - link to the publication
  2. Association of GLOD4 with Alzheimer's Disease in Humans and Mice
    Authors:
    Utyro O, Włoczkowska-Łapińska O, Jakubowski H.
    Academic press:
    J Alzheimers Dis (rok: 2024, tom: 101, strony: 823-834), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-240512 - link to the publication
  3. Homocysteine Thiolactone Detoxifying Enzymes and Alzheimer's Disease
    Authors:
    Jakubowski H.
    Academic press:
    Int J Mol Sci (rok: 2024, tom: 25, strony: art. 8095), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25158095 - link to the publication
  4. Association of Metallic and Nonmetallic Elements with Fibrin Clot Properties and Ischemic Stroke
    Authors:
    Jakubowski H, Sikora M, Bretes E, Perła-Kaján J, Utyro O, Wojtasz I, Kaźmierski R, Frankowski M, Zioła-Frankowska A.
    Academic press:
    Life (Basel) (rok: 2024, tom: 14, strony: art. 634), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/life14050634 - link to the publication
  5. The Molecular Bases of Anti-Oxidative and Anti-Inflammatory Properties of Paraoxonase 1
    Authors:
    Jakubowski H.
    Academic press:
    Antioxidants (rok: 2024, tom: 13, strony: art. 1292), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox13111292 - link to the publication
  6. Homocysteine metabolites inhibit autophagy by upregulating miR‑21‑5p, miR‑155‑5p, miR‑216‑5p, and miR‑320c‑3p in human vascular endothelial cells
    Authors:
    Łukasz Witucki, Hieronim Jakubowski
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 7151), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s441598-024-57750-3 - link to the publication
  7. Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression of histone demethylase PHF8-targeting microRNAs in human vascular endothelial cells and mice
    Authors:
    Witucki Ł, Jakubowski H
    Academic press:
    FASEB Journal (rok: 2024, tom: 38, strony: e70072), Wydawca: Wiley Periodicals LLC
    Status:
    Published
    DOI:
    10.1096/fj.202302116R - link to the publication
  8. Proteomic Exploration of Paraoxonase 1 Function in Health and Disease
    Authors:
    Hieronim Jakubowski
    Academic press:
    Int J Mol Sci (rok: 2023, tom: 24, strony: 7764), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24097764 - link to the publication
  9. Homocysteine thiolactone and other sulfur-containing amino acid metabolites are associated with fibrin clot properties and the risk of ischemic stroke
    Authors:
    Sikora M, Bretes E, Perła-Kaján J, Utyro O, Borowczyk K, Piechocka J, Głowacki R, Wojtasz I, Kaźmierski R, Jakubowski H.
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: art. 11222), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-024-60706-2 - link to the publication
  10. Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory- and Neurological Deficits and Worsens Alzheimer's Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer's Disease.
    Authors:
    Witucki Ł, Borowczyk K, Suszyńska-Zajczyk J, Warzych E, Pawlak E, Jakubowski H.
    Academic press:
    J Alzheimer's Dis (rok: 2023, tom: 95(4), strony: 1735-1755), Wydawca: IOSpress
    Status:
    Published
    DOI:
    10.3233/JAD-230578 - link to the publication
  11. Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice
    Authors:
    Łukasz Witucki, Hieronim Jakubowski
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 746), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells12050746 - link to the publication
  12. Homocysteine metabolites inhibit autophagy by upregulating miR‑21‑5p, miR‑155‑5p, miR‑216‑5p, and miR‑320c‑3p in human vascular endothelial cells
    Authors:
    Łukasz Witucki, Hieronim Jakubowski
    Academic press:
    Scientific Reprts , Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s441598-024-57750-3 - link to the publication

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