Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Novel role of peroxisome proliferator-activated receptor α in the regulationof amyloid β peptide metabolism and mitochondrial function in an animalmodel of Alzheimer's disease

2019/35/N/NZ4/03706

Keywords:

Alzheimer's disease PPAR-alpha receptor neuroprotection fenofibrate GW7647

Descriptors:

  • NZ4_009:
  • NZ7_012:
  • NZ3_007:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Sylwia Żulińska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 18 - announced on 2019-09-16

Amount awarded: 209 760 PLN

Project start date (Y-m-d): 2020-07-29

Project end date (Y-m-d): 2024-07-28

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. Recent Insights on the Role of PPAR‑β/δ in Neuroinflammation and Neurodegeneration, and Its Potential Target for Therapy
    Authors:
    Anna K. Strosznajder · Sylwia Wójtowicz · Mieszko J. Jeżyna · Grace Y. Sun · Joanna B. Strosznajder
    Academic press:
    NeuroMolecular Medicine (rok: 2021, tom: 1, strony: 86-98), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12017-020-08629-9 - link to the publication
  2. The role of synthetic ligand of PPARα in regulation of transcription of genes related to mitochondria biogenesis and dynamic in an animal model of Alzheimer's disease
    Authors:
    Sylwia Żulińska1, Anna K. Strosznajder2, Joanna B. Strosznajder1
    Academic press:
    Folia Neuropatologica (rok: 2023, tom: 2, strony: 138-143), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/fn.2023.129195 - link to the publication
  3. Current View on PPAR-α and Its Relation to Neurosteroids in Alzheimer's Disease and Other Neuropsychiatric Disorders: Promising Targets in a Therapeutic Strategy
    Authors:
    Żulińska, S. Strosznajder, A.K. Strosznajder, J.B.
    Academic press:
    Int. J. Mol. Sci. (rok: 2024, tom: 25, strony: 7106), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25137106 - link to the publication
  4. Alterations in mRNA level of proteins related to redox state and mitochondria in an Alzheimer's disease animal model: Promising targets in neuroprotection
    Authors:
    Sylwia Żulińska, Przemysław L. Wencel , Kinga Czubowicz, Joanna B. Strosznajder
    Academic press:
    Folia Neuropatholica (rok: 2024, tom: 3, strony: 237-248), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/fn.2024.143039 - link to the publication
  1. Age related alterations in mRNA level of genes related to redox state, mitochondria function and amyloid β homeostasis in animal model of Alzheimer's disease. Effect of fenofibrate
    Authors:
    S Żulińska, K Czubowicz, JB Strosznajder
    Conference:
    Folia Neuropatologica (rok: 2023, tom: Neuropatologia 2023, strony: 476), Wydawca: Termedia
    Data:
    konferencja 17-18 November 2023
    Status:
    Published
  2. PPAR-α synthetic ligands and their effect on the level of mRNA expression related to redox state and mitochondria proteins in different parts of the brain in an animal model of Alzheimer's disease
    Authors:
    S. Żulińska, K. Czubowicz, JB Strosznajder
    Conference:
    PPAR-α synthetic ligands and their effect on the level of mRNA expression related to redox state and mitochondria proteins in different parts of the brain in an animal model of Alzheimer's disease (rok: 2024, tom: 9th International Symposium on Experimental and Clinical Neurobiology, strony: 82), Wydawca: Kosice, Slovakia
    Data:
    konferencja 02-06.06. 2024
    Status:
    Published
  3. Age dependent alterations of transcription of genes encoding proteins related to mitochondria biogenesis in animal model of Alzheimer's disease
    Authors:
    Wójtowicz, S., Wieczorek, I., Strosznajder, R.P., Strosznajder, J.B.
    Conference:
    Folia Neuropathologica (rok: 2021, tom: Neuropatologia Neuroscience, strony: 430), Wydawca: Termida
    Data:
    konferencja 44519
    Status:
    Published
  4. Early alterations in transcription of genes coding NAD dependent- enzymes and mitochondria proteins in Alzheimer's disease animal model. Novel target(s) for neuroprotection.
    Authors:
    S. Wojtowicz, PL Wencel, I Wieczorek, JB Strosznajder, RP Strosznajder
    Conference:
    Virtual FENS Regional Meeting. Book of Abstrakct (rok: 2021, tom: FENS Regional Meeting 2021, strony: 309-307)
    Data:
    konferencja 2021-08-25-27
    Status:
    Published

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