Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Direct monitoring of the local dynamic rearrangement of the Alzheimer's peptides secondary structure upon the aggregation

2020/37/B/ST4/02990

Keywords:

molecular nano-spectroscopy Alzheimer's disease amyloid-β secondary structure aggregation tip-enhanced Raman spectroscopy (TERS) nanoFTIR

Descriptors:

  • ST4_002:
  • ST4_009:
  • NZ1_001:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ewelina Lipiec 

Number of co-investigators in the project: 8

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 2 802 276 PLN

Project start date (Y-m-d): 2021-02-01

Project end date (Y-m-d): 2026-01-31

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  1. Variabilities in global DNA methylation and β-sheet richness establish spectroscopic landscapes among subtypes of pancreatic cancer
    Authors:
    Krzysztof Szymoński, Ewelina Lipiec, Kamila Sofińska, Katarzyna Skirlińska-Nosek, Michał Czaja, Sara Seweryn, Natalia Wilkosz, Giovanni Birarda, Federica Piccirilli, Lisa Vaccari, Łukasz Chmura, Joanna Szpor, Dariusz Adamek & Marek Szymoński
    Academic press:
    European Journal of Nuclear Medicine and Molecular Imaging (rok: 2023, tom: ., strony: .), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00259-023-06121-7 - link to the publication
  2. Revealing local molecular distribution, orientation, phase separation, and formation of domains in artificial lipid layers: Towards comprehensive characterization of biological membranes
    Authors:
    Kamila Sofińska, Dawid Lupa, Anna Chachaj-Brekiesz, Michał Czaja, Jan Kobierski, Sara Seweryn, Katarzyna Skirlińska-Nosek, Marek Szymonski, Natalia Wilkosz, Anita Wnętrzak, Ewelina Lipiec
    Academic press:
    Advances in Colloid and Interface Science (rok: 2022, tom: 301, strony: 102614), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cis.2022.102614 - link to the publication
  3. Vibrational spectroscopy – are we close to finding a solution for early pancreatic cancer diagnosis? Szymoński K, Chmura Ł, Lipiec E, Adamek D. Vibrational spectroscopy – are we close to finding a solution for early pancreatic cancer diagnosis?
    Authors:
    Krzysztof Szymoński, Łukasz Chmura, Ewelina Lipiec, Dariusz Adamek
    Academic press:
    World Journal of Gastroenterology (rok: 2023, tom: 29, strony: 96-109), Wydawca: Baishideng Publishing Group Inc.
    Status:
    Published
    DOI:
    10.3748/wjg.v29.i1.96 - link to the publication
  4. Fabrication of plasmonic probes for reproducible nanospectroscopic investigation of lipid monolayers–The electrochemical etching with DC-pulsed voltage
    Authors:
    Michał Czaja, Anna Chachaj-Brekiesz, Katarzyna Skirlińska-Nosek, Konrad Szajna, Kamila Sofińska, Dawid Lupa, Jan Kobierski, Anita Wnętrzak, Marek Szymoński, Ewelina Lipiec
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2024, tom: 316, strony: 124323), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2024.124323 - link to the publication
  5. Combined analytical approach empowers precise spectroscopic interpretation of subcellular components of pancreatic cancer cells
    Authors:
    Krzysztof Szymoński, Katarzyna Skirlińska-Nosek, Ewelina Lipiec, Kamila Sofińska, Michał Czaja, Natalia Wilkosz, Matylda Krupa, Filip Wanat, Magdalena Ulatowska-Białas & Dariusz Adamek
    Academic press:
    Analytical and Bioanalytical Chemistry (rok: 2023, tom: 415, strony: 7281–7295), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00216-023-04997-w - link to the publication
  6. Oxysterols can act antiviral through modification of lipid membrane properties – The Langmuir monolayer study
    Academic press:
    The Journal of Steroid Biochemistry and Molecular Biology (rok: 2022, tom: 220, strony: ), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jsbmb.2022.106092 - link to the publication
  7. Nanoscale insights into the local structural rearrangements of amyloid-β induced by bexarotene
    Authors:
    Kamila Sofińska, Piotr Batys, Adrian Cernescu, Dhiman Ghosh, Katarzyna Skirlińska-Nosek, Jakub Barbasz, Sara Seweryn, Natalia Wilkosz, Roland Riek, Marek Szymoński, Ewelina Lipiec
    Academic press:
    Nanoscale (rok: 2023, tom: 15, strony: 14606-14614), Wydawca: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D3NR01608K - link to the publication
  8. Current Pathology Model of Pancreatic Cancer
    Authors:
    Krzysztof Szymoński, Katarzyna Milian-Ciesielska, Ewelina Lipiec, Dariusz Adamek
    Academic press:
    Cancers (rok: 2022, tom: 14, strony: 2321), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers14092321. - link to the publication
  9. Vibrational spectroscopy – are we close to finding a solution for early pancreatic cancer diagnosis? Szymoński K, Chmura Ł, Lipiec E, Adamek D. Vibrational spectroscopy – are we close to finding a solution for early pancreatic cancer diagnosis?
    Authors:
    Krzysztof Szymoński, Łukasz Chmura, Ewelina Lipiec, Dariusz Adamek
    Academic press:
    World Journal of Gastroenterology (rok: 2023, tom: 29, strony: 96-109), Wydawca: Baishideng Publishing Group Inc.
    Status:
    Published
    DOI:
    10.3748/wjg.v29.i1.96 - link to the publication
  10. Variabilities in global DNA methylation and β-sheet richness establish spectroscopic landscapes among subtypes of pancreatic cancer
    Authors:
    Krzysztof Szymoński, Ewelina Lipiec, Kamila Sofińska, Katarzyna Skirlińska-Nosek, Michał Czaja, Sara Seweryn, Natalia Wilkosz, Giovanni Birarda, Federica Piccirilli, Lisa Vaccari, Łukasz Chmura, Joanna Szpor, Dariusz Adamek & Marek Szymoński
    Academic press:
    European Journal of Nuclear Medicine and Molecular Imaging (rok: 2023, tom: ., strony: .), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00259-023-06121-7 - link to the publication
  11. Combined analytical approach empowers precise spectroscopic interpretation of subcellular components of pancreatic cancer cells
    Authors:
    Krzysztof Szymoński, Katarzyna Skirlińska-Nosek, Ewelina Lipiec, Kamila Sofińska, Michał Czaja, Natalia Wilkosz, Matylda Krupa, Filip Wanat, Magdalena Ulatowska-Białas & Dariusz Adamek
    Academic press:
    Analytical and Bioanalytical Chemistry (rok: 2023, tom: 415, strony: 7281–7295), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00216-023-04997-w - link to the publication

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