Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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MicroRNAs in blood as biomarkers for Alzheimer's disease: molecular signature for personalized therapy

2018/29/B/NZ7/02757

Keywords:

Alzheimer's disease prevention diagnostics therapy pathogenesis molecular mechanism epigenetic regulation microRNA non-invasive biomarkers biomarkers in blood tau protein BACE1 ERK1 cell cycle regulation apoptosis

Descriptors:

  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Urszula Wojda 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 130 600 PLN

Project start date (Y-m-d): 2019-01-28

Project end date (Y-m-d): 2024-07-27

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Antisense oligonucleotides for Alzheimer's disease therapy: from the mRNA to miRNA paradigm
    Authors:
    Wioleta Grabowska-Pyrzewicz, Andrew Want, Jerzy Leszek, Urszula Wojda
    Academic press:
    EBioMedicine - part of The Lancet (rok: 2021, tom: 74, strony: 103691), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ebiom.2021.103691 - link to the publication
  2. Candidate Alzheimer's disease biomarker miR-483-5p lowers TAU phosphorylation by direct ERK1/2 repression
    Authors:
    Siranjeevi Nagaraj, Andrew Want, Katarzyna Laskowska-Kaszub, Alexandra Fesiuk, Sara Vaz, Elsa Logarinho, Urszula Wojda
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  3. Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration
    Authors:
    Angelika Więckowska-Gacek , Anna Mietelska-Porowska , Małgorzata Wydrych , Urszula Wojda
    Academic press:
    Ageing Research Reviews (rok: 2021, tom: 70, strony: 101397), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.arr.2021.101397 - link to the publication
  4. The Perspective of Exosomal MicroRNAs as Biomarkers for Preclinical Alzheimer's Disease
    Authors:
    Urszula Wojda
    Academic press:
    Biological Psychiatry (rok: 2022, tom: 92, strony: 45419), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopsych.2022.04.006 - link to the publication
  5. Optimized RT‑qPCR and a novel normalization method for validating circulating miRNA biomarkers in ageing‑related diseases
    Authors:
    Want A, Staniak K, Grabowska-Pyrzewicz W, Fesiuk A, Barczak A, Gabryelewicz T, Kulczyńska-Przybik A, Mroczko B, Wojda U
    Academic press:
    Scientific Reports (rok: 2023, tom: 13, strony: 20869), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-47971-3 - link to the publication
  6. miR-483-5p orchestrates the initiation of protein synthesis by facilitating the decrease in phosphorylated Ser209eIF4E and 4E-BP1 levels.
    Authors:
    S Nagaraj, A Stankiewicz-Drogon, E Darzynkiewicz, U Wojda*(corresponding author), R Grzela*
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 4237), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-024-54154-1 - link to the publication

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