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The role of bioactive sphingolipids: ceramide, ceramide-1-phosphate and sphingosine-1-phosphate in regulation of mitochondria and synaptic function in experimental models of Alzheimer Disease. The non-amyloid targets in AD therapy.

2014/15/B/NZ3/01049

Keywords

Descriptors

  • NZ3_4: Starzenie
  • NZ3_7: Przekaźnictwo sygnału
  • NZ3_3: Apoptoza

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Robert Piotr Strosznajder

Number of co-investigators in the project: 6

Call

OPUS 8 – announced on 2014-09-15

Amount awarded
889 600 PLN
Project start date
2015-09-22
Project end date
2019-09-21
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Urzadzenie do pomiaru pH (phmetr).
  2. Waga analityczna. Cost: 8 000 PLN
  3. komputer osobisty z oprogramowaniem (statystycznym i graficznym). Cost: 7 000 PLN
  4. kołyska laboratoryjna.
  5. mini wirówka dla PCR. Cost: 8 500 PLN
  6. wirówka z chłodzeniem.
  7. łaźnia wodna z wytrząsaniem. Cost: 12 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod

    Authors:
    Henryk Jęśko, Iga Wieczorek, Przemysław Leonard Wencel, Magdalena Gąssowska-Dobrowolska, Walter J. Lukiw and Robert Piotr Strosznajder
    Academic press:
    Frontiers in Molecular Neuroscience (year: 2021, volume: Volume 14, pages: 46037), Publisher: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fnmol.2021.660104 – link to the publication

  2. The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration.

    Authors:
    Jęśko H, Stępień A, Lukiw WJ, Strosznajder RP.
    Academic press:
    Molecular Neurobiology (year: 2019, volume: 56(5), pages: 3501-3521), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-018-1286-3 – link to the publication

  3. Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer's Disease.

    Authors:
    Jęśko H, Wencel PL, Lukiw WJ, Strosznajder RP.
    Academic press:
    Molecular Neurobiology (year: 2019, volume: 56(1), pages: 174-185), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-018-1040-x. – link to the publication

  4. Fingolimod Affects Transcription of Genes Encoding Enzymes of Ceramide Metabolism in Animal Model of Alzheimer's Disease

    Authors:
    Henryk Jęśko; Przemysław L. Wencel; Sylwia Wójtowicz; Joanna Strosznajder; Walter J. Lukiw; Robert P. Strosznajder
    Academic press:
    Molecular Neurobiology (year: 2020, volume: 57, pages: 2799-2811), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-020-01908-3 – link to the publication

  5. Alterations of transcription of genes coding anti-oxidative and mitochondria-related proteins in amyloid β toxicity: relevance to Alzheimer's disease

    Authors:
    Magdalena Cieślik, Grzegorz Czapski, Sylwia Wójtowicz, Iga Wieczorek, Przemysław Wencel, Robert Strosznajder, Vivian Jaber, Walter Lukiw, Joanna Strosznajder
    Academic press:
    Molecular Neurobiology (year: 2020, volume: 57 (3), pages: 1374-1388), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-019-01819-y – link to the publication

Articles in post-conference publications (15)

  1. Fingolimod (FTY720 – modulator of S1P receptors) alters genes expression of selected NAD+ - dependent enzymes in animal model of Alzheimer's disease.

    Authors:
    Wencel P.L., Jesko H., Strosznajder R. P.
    Conference:
    14th International Congress of the Polish Neuroscience Society (year: 2019, pages: 79 SUPPLEMENT: LXXX-LXXXI. ISSN 0065-1400), Publisher: Acta Neurobiologiae Experimentalis
    Date:
    conference 28-30 sierpień
    Status:
    Published

  2. The effect of sphingosine-1-phosphare receptors modulator on the transcriptional profile of genes linked to glutamate homeostasis in the sporadic and genetic animal models of Alzheimer's disease.

    Authors:
    3.Wencel P.L., Sulkowski G., Wojda R., Dąbrowska-Bouta B., Strużyńska L., Strosznajder R..
    Conference:
    14th International Congress of the Polish Neuroscience Society (year: 2019, pages: 79 SUPPLEMENT: LXXX. ISSN 0065-1400), Publisher: Acta Neurobiologiae Experimentalis
    Date:
    conference 28-30 sierpień
    Status:
    Published

  3. Alteration of genes expression related to mitochondria function in a mouse model of Alzheimer's Disease; effect of myriocin.

    Authors:
    Wójtowicz S. , Wencel P.L. , Wieczorek I. , Strosznajder J.B. , Strosznajder R.P.
    Conference:
    20th INTERNATIONAL CONGRESS of the Polish Pharmacological Society (year: 2019, pages: Abstract book pages 96-97), Publisher: materiały organizatora
    Date:
    conference 5-7 Czerwiec
    Status:
    Published

  4. Myriocin alters gene expression of proteins engaged in mitochondria biogenesis and dynamics in Alzheimer's Disease transgenic mouse model.

    Authors:
    Strosznajder R.P., Wojtowicz S., Wencel P.L
    Conference:
    18th National Meeting of the Spanish Society of Neuroscience (year: 2019, pages: xx), Publisher: materiały organizatora
    Date:
    conference 4-6 września
    Status:
    Published

  5. Effect of myriocin and FTY720 on gene expression of sphingolipid enzymes in mouse model of Alzheimer's disease

    Authors:
    Jęśko H, Wencel P.L, Strosznajder R.P
    Conference:
    The 13 th International Symposium Molecular Basis of Pathology and therapy in neurological disorders (year: 2016, pages: Folia Neuropatholog. 2016; 54/3, p. 335, B7), Publisher: Termedia Publishing House; Folia Neuropathologica
    Date:
    conference November17-18
    Status:
    Published

  6. The effect of FTY720 on genes expression of sphingolipids metabolism enzymes in brain cortex of Alzheimer's transgenic mice.

    Authors:
    Wencel P. L., Jesko H., Strosznajder R. P.
    Conference:
    Neurochemical Conference 2017 Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches (year: 2017, pages: 278 ( strona 30 w załaczonym pdf)), Publisher: Termedia Publishing House, Folia Neuropathologica
    Date:
    conference Październik 19-20
    Status:
    Published

  7. Alterations in genes expression of sphingolipids metabolism enzymes in animal model of Alzheimer's disease.

    Authors:
    Wencel P. L., Jesko H., Strosznajder R. P.
    Conference:
    Neurochemical Conference 2017 Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches. (year: 2017, pages: 278 (strona 30 w załaczonym pdf)), Publisher: Termedia Publishing House, Folia Neuropathologica
    Date:
    conference Październik 19-20
    Status:
    Published

  8. The effects of fingolimod on the expression of genes involved in ceramide metabolism in a murine model of Alzheimer's disease

    Authors:
    Jęśko H, Wencel PL, Strosznajder RP.
    Conference:
    14th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS October 25-26, 2018 Warsaw, Poland (year: 2018, pages: 249), Publisher: Termedia
    Date:
    conference October 25-26
    Status:
    Published

  9. Fingolimod modulates genes' expressions of sphingolipids metabolism enzymes and mitochondrial respiratory chain proteins in hippocampus of Alzheimer's transgenic mice

    Authors:
    Strosznajder RP, Wencel PL, Jęśko H.
    Conference:
    19th Biennial Meeting of the Society-for-Free-Radical-Research-International (SFRRI). 4-7 June 2018, Lisbon, Portugal. (year: 2018, pages: S131), Publisher: Elsevier
    Date:
    conference 4-7 June 2018
    Status:
    Published
    DOI:
    link to the publication

  10. Effects of myriocin and fty720 on gene expression of sphingolipid metabolism enzymes in animal model of Alzheimer's disease.

    Authors:
    Jesko H., Wencel P. L., Strosznajder R.
    Conference:
    13th International Congress of the Polish Neuroscience Society. (year: 2017, pages: 53-54 ( w zalaczonym pdf to strony 56-57)), Publisher: Acta Neurobiol Exp ( vol. 77)
    Date:
    conference Sierpień 28-31
    Status:
    Published

  11. Bioactive sphingolipids in experimental models of Alzheimer's Disease. Effect of Myriocin.

    Authors:
    Strosznajder R., Wencel P., Jęśko H.
    Conference:
    AD/PD 2017, the 13th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders (year: 2017, pages: 72), Publisher: materiały organizatora AD/PD
    Date:
    conference Marzec 29-Kwiecień 2
    Status:
    Published

  12. Alteration in gene expression of sphingolipid metabolism enzymes in PC-12 cell line transfected with amyloid precursor protein

    Authors:
    Wencel P.L, Strosznajder R.P
    Conference:
    The 13th International Symposium Molecular basis of pathology and therapy in neurological disorders (year: 2016, pages: Folia Neuropatholog. 2016; 54/3, p. 348), Publisher: Termedia Publishing House; Folia Neuropathologica
    Date:
    conference November 17-18, 2016
    Status:
    Published

  13. Enzyme inhibitors myriocin and FTY720 modulate the expression of sphingolipid metabolism genes in animal models of Alzheimer's disease.

    Authors:
    Jesko H., Wencel P.L., Strosznajder R.
    Conference:
    8th International Symposium on Experimental and Clinical Neurobiology. (year: 2017, pages: 45), Publisher: materiały organizatora
    Date:
    conference Czerwiec 18–21
    Status:
    Published

  14. Alteration of glutamatergic receptor(s) transcription in animal model of sporadic Alzheimer's disease. Effects of myriocin.

    Authors:
    Wencel P.L., Sulkowski G., Wojda R., Dąbrowska-Bouta B., Strużyńska L., Strosznajder R.
    Conference:
    8th International Symposium on Experimental and Clinical Neurobiology. Kosice, Slovakia. (year: 2017, pages: 88), Publisher: materiały organizatora
    Date:
    conference Czerwiec 18–21
    Status:
    Published

  15. Myriocin alters transcription of NAD+ dependent enzymes in animal model of Alzheimer's disease

    Authors:
    Wencel PL, Jęśko H, Wojda R, Strosznajder RP
    Conference:
    14th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS October 25-26, 2018 Warsaw, Poland (year: 2018, pages: 257), Publisher: Termedia
    Date:
    conference October 25-26
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski