Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of bioactive sphingolipids: ceramide, ceramide-1-phosphate and sphingosine-1-phosphate in regulation of mitochondria and synaptic function in experimental models of Alzheimer Disease. The non-amyloid targets in AD therapy.

2014/15/B/NZ3/01049

Keywords:

sphingolipids ceramide S1P C1P mitochondria AD

Descriptors:

  • NZ3_4: Ageing
  • NZ3_7: Signal transduction
  • NZ3_3: Apoptosis

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Robert Strosznajder 

Number of co-investigators in the project: 6

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 889 600 PLN

Project start date (Y-m-d): 2015-09-22

Project end date (Y-m-d): 2019-09-21

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Waga analityczna (8 000 PLN)
  2. komputer osobisty z oprogramowaniem (statystycznym i graficznym) (7 000 PLN)
  3. wirówka z chłodzeniem.
  4. mini wirówka dla PCR (8 500 PLN)
  5. łaźnia wodna z wytrząsaniem (12 000 PLN)
  6. Urzadzenie do pomiaru pH (phmetr).
  7. kołyska laboratoryjna.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (15)
  1. Fingolimod Affects Transcription of Genes Encoding Enzymes of Ceramide Metabolism in Animal Model of Alzheimer's Disease
    Authors:
    Henryk Jęśko; Przemysław L. Wencel; Sylwia Wójtowicz; Joanna Strosznajder; Walter J. Lukiw; Robert P. Strosznajder
    Academic press:
    Molecular Neurobiology (rok: 2020, tom: 57, strony: 2799-2811), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-020-01908-3 - link to the publication
  2. Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod
    Authors:
    Henryk Jęśko, Iga Wieczorek, Przemysław Leonard Wencel, Magdalena Gąssowska-Dobrowolska, Walter J. Lukiw and Robert Piotr Strosznajder
    Academic press:
    Frontiers in Molecular Neuroscience (rok: 2021, tom: Volume 14, strony: 45306), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fnmol.2021.660104 - link to the publication
  3. Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer's Disease.
    Authors:
    Jęśko H, Wencel PL, Lukiw WJ, Strosznajder RP.
    Academic press:
    Molecular Neurobiology (rok: 2019, tom: 56(1), strony: 174-185), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-018-1040-x. - link to the publication
  4. Alterations of transcription of genes coding anti-oxidative and mitochondria-related proteins in amyloid β toxicity: relevance to Alzheimer's disease
    Authors:
    Magdalena Cieślik, Grzegorz Czapski, Sylwia Wójtowicz, Iga Wieczorek, Przemysław Wencel, Robert Strosznajder, Vivian Jaber, Walter Lukiw, Joanna Strosznajder
    Academic press:
    Molecular Neurobiology (rok: 2020, tom: 57 (3), strony: 1374-1388), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-019-01819-y - link to the publication
  5. The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration.
    Authors:
    Jęśko H, Stępień A, Lukiw WJ, Strosznajder RP.
    Academic press:
    Molecular Neurobiology (rok: 2019, tom: 56(5), strony: 3501-3521), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-018-1286-3 - link to the publication
  1. Myriocin alters gene expression of proteins engaged in mitochondria biogenesis and dynamics in Alzheimer's Disease transgenic mouse model.
    Authors:
    Strosznajder R.P., Wojtowicz S., Wencel P.L
    Conference:
    18th National Meeting of the Spanish Society of Neuroscience (rok: 2019, ), Wydawca: materiały organizatora
    Data:
    konferencja 4-6 września
    Status:
    Published
  2. Myriocin alters transcription of NAD+ dependent enzymes in animal model of Alzheimer's disease
    Authors:
    Wencel PL, Jęśko H, Wojda R, Strosznajder RP
    Conference:
    14th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS October 25-26, 2018 Warsaw, Poland (rok: 2018, ), Wydawca: Termedia
    Data:
    konferencja October 25-26
    Status:
    Published
  3. The effect of FTY720 on genes expression of sphingolipids metabolism enzymes in brain cortex of Alzheimer's transgenic mice.
    Authors:
    Wencel P. L., Jesko H., Strosznajder R. P.
    Conference:
    Neurochemical Conference 2017 "Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches (rok: 2017, ), Wydawca: Termedia Publishing House, Folia Neuropathologica
    Data:
    konferencja Październik 19-20
    Status:
    Published
  4. The effect of sphingosine-1-phosphare receptors modulator on the transcriptional profile of genes linked to glutamate homeostasis in the sporadic and genetic animal models of Alzheimer's disease.
    Authors:
    3.Wencel P.L., Sulkowski G., Wojda R., Dąbrowska-Bouta B., Strużyńska L., Strosznajder R..
    Conference:
    14th International Congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 28-30 sierpień
    Status:
    Published
  5. Alteration of genes expression related to mitochondria function in a mouse model of Alzheimer's Disease; effect of myriocin.
    Authors:
    Wójtowicz S. , Wencel P.L. , Wieczorek I. , Strosznajder J.B. , Strosznajder R.P.
    Conference:
    20th INTERNATIONAL CONGRESS of the Polish Pharmacological Society (rok: 2019, ), Wydawca: materiały organizatora
    Data:
    konferencja 5-7 Czerwiec
    Status:
    Published
  6. Effect of myriocin and FTY720 on gene expression of sphingolipid enzymes in mouse model of Alzheimer's disease
    Authors:
    Jęśko H, Wencel P.L, Strosznajder R.P
    Conference:
    The 13 th International Symposium "Molecular Basis of Pathology and therapy in neurological disorders" (rok: 2016, ), Wydawca: Termedia Publishing House; Folia Neuropathologica
    Data:
    konferencja November17-18
    Status:
    Published
  7. Effects of myriocin and fty720 on gene expression of sphingolipid metabolism enzymes in animal model of Alzheimer's disease.
    Authors:
    Jesko H., Wencel P. L., Strosznajder R.
    Conference:
    13th International Congress of the Polish Neuroscience Society. (rok: 2017, ), Wydawca: Acta Neurobiol Exp ( vol. 77)
    Data:
    konferencja Sierpień 28-31
    Status:
    Published
  8. Alteration in gene expression of sphingolipid metabolism enzymes in PC-12 cell line transfected with amyloid precursor protein
    Authors:
    Wencel P.L, Strosznajder R.P
    Conference:
    The 13th International Symposium "Molecular basis of pathology and therapy in neurological disorders (rok: 2016, ), Wydawca: Termedia Publishing House; Folia Neuropathologica
    Data:
    konferencja November 17-18, 2016
    Status:
    Published
  9. Alteration of glutamatergic receptor(s) transcription in animal model of sporadic Alzheimer's disease. Effects of myriocin.
    Authors:
    Wencel P.L., Sulkowski G., Wojda R., Dąbrowska-Bouta B., Strużyńska L., Strosznajder R.
    Conference:
    8th International Symposium on Experimental and Clinical Neurobiology. Kosice, Slovakia. (rok: 2017, ), Wydawca: materiały organizatora
    Data:
    konferencja Czerwiec 18–21
    Status:
    Published
  10. Enzyme inhibitors myriocin and FTY720 modulate the expression of sphingolipid metabolism genes in animal models of Alzheimer's disease.
    Authors:
    Jesko H., Wencel P.L., Strosznajder R.
    Conference:
    8th International Symposium on Experimental and Clinical Neurobiology. (rok: 2017, ), Wydawca: materiały organizatora
    Data:
    konferencja Czerwiec 18–21
    Status:
    Published
  11. Fingolimod (FTY720 – modulator of S1P receptors) alters genes expression of selected NAD+ - dependent enzymes in animal model of Alzheimer's disease.
    Authors:
    Wencel P.L., Jesko H., Strosznajder R. P.
    Conference:
    14th International Congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 28-30 sierpień
    Status:
    Published
  12. Alterations in genes expression of sphingolipids metabolism enzymes in animal model of Alzheimer's disease.
    Authors:
    Wencel P. L., Jesko H., Strosznajder R. P.
    Conference:
    Neurochemical Conference 2017 "Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation: novel therapeutic approaches. (rok: 2017, ), Wydawca: Termedia Publishing House, Folia Neuropathologica
    Data:
    konferencja Październik 19-20
    Status:
    Published
  13. Bioactive sphingolipids in experimental models of Alzheimer's Disease. Effect of Myriocin.
    Authors:
    Strosznajder R., Wencel P., Jęśko H.
    Conference:
    AD/PD 2017, the 13th International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders (rok: 2017, ), Wydawca: materiały organizatora AD/PD
    Data:
    konferencja Marzec 29-Kwiecień 2
    Status:
    Published
  14. Fingolimod modulates genes' expressions of sphingolipids metabolism enzymes and mitochondrial respiratory chain proteins in hippocampus of Alzheimer's transgenic mice
    Authors:
    Strosznajder RP, Wencel PL, Jęśko H.
    Conference:
    19th Biennial Meeting of the Society-for-Free-Radical-Research-International (SFRRI). 4-7 June 2018, Lisbon, Portugal. (rok: 2018, ), Wydawca: Elsevier
    Data:
    konferencja 4-7 June 2018
    Status:
    Published
    DOI:
    link to the publication
  15. The effects of fingolimod on the expression of genes involved in ceramide metabolism in a murine model of Alzheimer's disease
    Authors:
    Jęśko H, Wencel PL, Strosznajder RP.
    Conference:
    14th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS October 25-26, 2018 Warsaw, Poland (rok: 2018, ), Wydawca: Termedia
    Data:
    konferencja October 25-26
    Status:
    Published

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