Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Transgenic mice with elevated basal level of calcium ions in neurons as a model of aged-induced neurodegeneration of sporadic Alzheimer's disease

2011/02/A/NZ3/00144

Keywords:

Alzheimer's Disease beta-amyloid animal models of AD Ca2+ homeostasis Store Operated Calcium Entry ORAI1 STIM1 STIM2 transgenic mice constitutive and inducible expression ageing behavior tests learning and memory CREB LTP LTD

Descriptors:

  • NZ3_4: Ageing
  • NZ3_5: Molecular neurobiology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jacek Kuźnicki 

Number of co-investigators in the project: 14

Call: MAESTRO 1 - announced on 2011-06-15

Amount awarded: 2 989 800 PLN

Project start date (Y-m-d): 2012-05-11

Project end date (Y-m-d): 2019-05-11

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komora przyżyciowa wraz z platforma mocującą, regulator temperatury i podgrzewacz cieczy z osprzętem.
  2. Zestaw do mikroiniekcji (27 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (4)
  • Book publications / chapters in book publications (1)
  1. Overexpression of STIM1 in neurons in mouse brain improves contextual learning and impairs long-term depression.
    Authors:
    Majewski Ł, Maciąg F, Boguszewski PM, Wasilewska I, Wiera G, Wójtowicz T, Mozrzymas J, Kuźnicki J.
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (rok: 2017, tom: 1864(6), strony: 1071-1087), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2016.11.025. - link to the publication
  2. Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration
    Authors:
    Majewski L, Maciąg F, Boguszewski PM, Kuznicki J.
    Academic press:
    Int J Mol Sci. (rok: 2020, tom: 21(3):842, strony: 21(3):842), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21030842 - link to the publication
  3. Behavioral and electrophysiological changes in female mice overexpressing ORAI1 in neurons.
    Authors:
    Maciąg F, Majewski Ł, Boguszewski PM, Gupta RK, Wasilewska I, Wojtaś B, Kuźnicki J.
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (rok: 2019, tom: 1866, strony: 1137-1150), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2019.01.007 - link to the publication
  4. STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons
    Authors:
    Gruszczynska-Biegala J, Strucinska K, Maciag F, Majewski L, Sladowska M, Kuznicki J.
    Academic press:
    Cells (rok: 2020, tom: 9(1):160, strony: 9(1):160), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9010160 - link to the publication
  5. Alzheimer's Disease Modeling: Ups, Downs, and Perspectives for Human Induced Pluripotent Stem Cells
    Authors:
    Wojda U, Kuźnicki J.
    Academic press:
    Journal of Alzheimer's Disease (rok: 2013, tom: 34(3), strony: 563-88), Wydawca: IOS PRESS
    Status:
    Published
    DOI:
    10.3233/JAD-121984 - link to the publication
  6. Neuronal calcium signaling via store-operated channels in health and disease
    Authors:
    Węgierski T, Kuźnicki J.
    Academic press:
    Cell Calcium (rok: 2018, tom: Volume 74, strony: 102-111), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ceca.2018.07.001 - link to the publication
  7. Changes in Calcium Homeostasis and Gene Expression Implicated in Epilepsy in Hippocampi of Mice Overexpressing ORAI1
    Authors:
    Majewski L, Wojtas B, Maciąg F, Kuznicki J.
    Academic press:
    Int J Mol Sci. (rok: 2019, tom: 20(22):5539, strony: 20(22):5539), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20225539 - link to the publication
  8. SOCE in neurons: Signaling or just refilling?
    Authors:
    Majewski Ł, Kuznicki J.
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (rok: 2015, tom: 1853(9), strony: 1940-1952), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2015.01.019 - link to the publication
  1. Profile expression of STIM2.1, a newly discovered STIM2 splice variant in immune cells, in mouse brain structures at different times of development
    Authors:
    Majewski Ł, Wasilewska I, Niemeyer BA, Kuźnicki J.
    Conference:
    13th International Congress of the Polish Neuroscience Society (rok: 2017, ), Wydawca: Acta Neurobiol Exp
    Data:
    konferencja 28-31.08.2017
    Status:
    Published
  2. STIM1 overexpression in transgenic mice brain leads to changes in synaptic plasticity
    Authors:
    Majewski Ł, Maciąg F, Wiera G, Wójtowicz T, Mozrzymas J, Kuźnicki J.
    Conference:
    XIV International Meeting of the European Calcium Society Calcium Signaling in Renaissance (rok: 2016, ), Wydawca: European Calcium Society
    Data:
    konferencja 25.09-29.09.2016
    Status:
    Published
  3. Synaptic Deficits in Alzheimer's Disease and Neurodegeneration II
    Authors:
    Majewski Ł, Maciąg F, Boguszewski PM, Kuźnicki J.
    Conference:
    Annual Meeting of Society of Neuroscience (rok: 2017, ), Wydawca: Society for Neuroscience
    Data:
    konferencja 11-15.11.2017
    Status:
    Published
  4. Phenotyping a transgenic mouse line FVB/NJ Tg(Orai1)Ibd overexpressing ORAI1 in neurons
    Authors:
    Majewski Ł, Maciąg F, Boguszewski PM, Kuźnicki J.
    Conference:
    15th International Meeting of the European Calcium Society (rok: 2018, ), Wydawca: European Calcium Society
    Data:
    konferencja 09-13.09.2018
    Status:
    Published
  1. Rola homeostazy wapniowej w rozwoju choroby Alzheimera
    Authors:
    Dubicka-Boroch D, Kuźnicki J.
    Book:
    Choroba Alzheimera - wybrane zagadnienia biologiczne i kliniczne (rok: 2016, tom: ---, strony: 45310), Wydawca: Continuo
    Status:
    Published

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