Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Looking for the same pathological factors in ischemic brain and Alzheimer's disease;Genes

2013/09/B/NZ7/01345

Keywords:

Alzheimer's disease ischemic etiology amyloid secretases tau protein alpha-synuclein apolipoproteins expresion of genes

Descriptors:

  • NZ7_12: Prevention of human diseases
  • NZ5_1: Etiology of human diseases
  • NZ5_5: Diagnostics in human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ryszard Pluta 

Number of co-investigators in the project: 6

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 700 040 PLN

Project start date (Y-m-d): 2014-02-17

Project end date (Y-m-d): 2017-02-16

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Urządzenie do bezcieniowgo oświetlenia pola operacyjnego. (10 000 PLN)
  2. Maszyna do wytwarzania lodu. (15 000 PLN)
  3. Pompa do sztucznego oddychania. (50 000 PLN)
  4. Autoklaw do sterylizacji narzędzi, probówek, itp. (9 000 PLN)
  5. Zamrażarka niskotemperaturowa do -80 stopni.
  6. Mała szybko obrotowa wirówka. (6 000 PLN)
  7. Najnowocześniejszy zestaw komputerowy na trzy stanowiska z drukarkami, skanerem i najnowocześniejszymi programami Windows Office i do statystyki. (37 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Dysregulation of autophagy, mitophagy and apoptotic genes in the medial temporal lobe cortex in an ischemic model of Alzheimer's disease
    Authors:
    M.Ułamek-Kozioł, J.Kocki, A.Bogucka-Kocka, A.Petniak, P.Gil-Kulik, S.Januszewski, J.Bogucki, M.Jabłoński, W.Furmaga-Jabłońska, J.Brzozowska, S.J.Czuczwar, R.Pluta.
    Academic press:
    Journal of Alzheimers Disease (rok: 2016, tom: 54, strony: 113-121), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-160387. - link to the publication
  2. Brain ischemia with Alzheimer phenotype dysregulates Alzheimer's disease-related proteins.
    Authors:
    M.Ułamek-Kozioł, R.Pluta, A.Bogucka-Kocka, S.Januszewski, J.Kocki, S.J.Czuczwar.
    Academic press:
    Pharmacol Reports (rok: 2016, tom: 68, strony: 582-591), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2016.01.006. - link to the publication
  3. Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?
    Authors:
    Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Wanda Furmaga-Jabłońska, Sławomir Januszewski, Judyta Brzozowska, Mirosław Jabłoński, Janusz Kocki
    Academic press:
    Folia Neuropathologica (rok: 2015, tom: 53, strony: 89-99), Wydawca: terMedia
    Status:
    Published
    DOI:
    10.5114/fn.2015.52405 - link to the publication
  4. Seizure susceptibility to electroconvulsions or pentylenetetrazol after complete cerebral ischemia in rats due to cardiac arrest
    Authors:
    Monika Dudra-Jastrzebska, Marzena Ułamek-Kozioł, Marta Andres-Mach, Jarogniew J. Łuszczki, Sławomir Januszewski, Stanisław J. Czuczwar, Ryszard Pluta
    Academic press:
    Pharmacological Reports (rok: 2015, tom: 67, strony: 417-420), Wydawca: Elsevier
    Status:
    Published
  5. Alzheimer-associated presenilin 2 gene is dysregulated in rat medial temporal lobe cortex after complete brain ischemia due to cardiac arrest.
    Authors:
    R.Pluta, J.Kocki, M.Ułamek-Kozioł, A.Bogucka-Kocka, P.Gil-Kulik, S.Januszewski, M.Jabłoński, A.Petniak, J.Brzozowska, J.Bogucki, W.Furmaga-Jabłońska, S.J.Czuczwar.
    Academic press:
    Pharmacol Reports (rok: 2016, tom: 68, strony: 155-161), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2015.08.002. - link to the publication
  6. Discrepancy in expression of β-secretase and amyloid-β protein precursor in Alzheimer-related genes in the rat medial temporal lobe cortex following transient global brain ischemia.
    Authors:
    R.Pluta, J.Kocki, M.Ułamek-Kozioł, A.Petniak, P.Gil-Kulik, S.Januszewski, J.Bogucki, M.Jabłoński, J.Brzozowska, W.Furmaga-Jabłońska, A.Bogucka-Kocka, S.J.Czuczwar.
    Academic press:
    Journal of Alzheimers Disease (rok: 2016, tom: 51, strony: 1023-1031), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-151102. - link to the publication
  7. Dysregulation of amyloid-beta protein precursor, beta-secretase, presenilin 1 and 2 genes in the rat selectively vulnerable CA1 subfield of hippocampus following transient global brain ischemia
    Authors:
    Janusz Kockia, Marzena Ułamek-Kozioł, Anna Bogucka-Kocka, Sławomir Januszewski, Mirosław Jabłoński, Paulina Gil-Kulik, Judyta Brzozowska, Alicja Petniak, Wanda Furmaga-Jabłońska, Jacek Bogucki, Stanisław J. Czuczwar, Ryszard Pluta
    Academic press:
    Journal of Alzheimers Disease (rok: 2015, tom: 47, strony: 1047-1056), Wydawca: IOS Press
    Status:
    Published
    DOI:
    10.3233/JAD-150299 - link to the publication
  8. Occurrence of spontaneous and audiogenic seizures following global brain ischaemia due to cardiac arrest
    Authors:
    Marzena Ułamek-Kozioł, Janusz Kocki, Anna Bogucka-Kocka, Sławomir Januszewski, Stanisław J. Czuczwar, Ryszard Pluta
    Academic press:
    Folia Neuropathologica (rok: 2015, tom: 53, strony: 245-249), Wydawca: terMedia
    Status:
    Published
    DOI:
    10.5114/fn.2015.54425 - link to the publication
  9. Smell and salt: a delicate balance in health and disease
    Authors:
    Marzena Ułamek-Kozioł, Sławomir Januszewski, Ryszard Pluta, Mirosław Jabłoński
    Academic press:
    Nutrition (rok: 2014, tom: 30, strony: 1094-1096), Wydawca: Elsevier
    Status:
    Published
  10. Autophagy, mitophagy and apoptotic gene changes in the hippocampal CA1 area in a rat ischemic model of Alzheimer's disease.
    Authors:
    Ułamek-Kozioł M, Kocki J, Bogucka-Kocka A, Januszewski S, Bogucki J, Czuczwar SJ, Pluta R
    Academic press:
    Pharmacological Reports (rok: 2017, tom: 69, strony: 1289-1294), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2017.07.015. - link to the publication