Projects funded by the NCN

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Information of the project and the call

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The role of BET family proteins in microglia-dependent neurodegeneration; relevance to Alzheimer's disease

2018/31/B/NZ4/01379

Keywords:

microglia neuroinflammation amyloid beta Alzheimer's disease neurodegeneration BET proteins epigenetics

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ6_1: Adaptive and innate immunity
  • NZ3_5: Molecular neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Grzegorz Czapski 

Number of co-investigators in the project: 6

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 493 540 PLN

Project start date (Y-m-d): 2019-07-24

Project end date (Y-m-d): 2024-07-23

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (9)
  1. Glutamate and GABA in microglia-neuron cross-talk in Alzheimer's disease.
    Authors:
    Czapski GA, Strosznajder JB.
    Academic press:
    IJMS (rok: 2021, tom: 22, strony: 11677), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222111677 - link to the publication
  2. The Role of Bromodomain and Extraterminal (BET) Proteins in Controlling the Phagocytic Activity of Microglia In Vitro: Relevance to Alzheimer's Disease
    Authors:
    Matuszewska M, Cieślik M, Wilkaniec A, Strawski M, Czapski GA
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 24, strony: 13), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24010013 - link to the publication
  3. Inhibitor of bromodomain and extraterminal domain proteins decreases transcription of Cd33 in the brain of mice subjected to systemic inflammation
    Authors:
    Czapski GA, Matuszewska M, Cieślik M, Strosznajder JS
    Academic press:
    Folia Neuropathologica (rok: 2024, tom: 62, strony: brak), Wydawca: Termedia
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  4. Acute Systemic Inflammatory Response Alters Transcription Profile of Genes Related to Immune Response and Ca2+ Homeostasis in Hippocampus; Relevance to Neurodegenerative Disorders.
    Authors:
    Czapski GA, Zhao Y, Lukiw WJ, StrosznajderJB.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 7838), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21217838 - link to the publication
  1. Acute systemic inflammatory response alters expression of genes related to calcium homeostasis, epigenetic regulation, and lipid metabolism in hippocampus; relevance to Alzheimer's disease.
    Authors:
    Czapski G, Zhao Y, Lukiw WJ, Strosznajder JB.
    Conference:
    webinarium: Neuropatologia kliniczna i eksperymentalna (rok: 2020, ), Wydawca: Termedia, Folia Neuropathol.
    Data:
    konferencja 27.11.2020
    Status:
    Published
  2. Inhibition of bromodomain and extraterminal (BET) proteins modulates inflammation-induced sickness behavior; the relevance to Alzheimer's disease-related depression
    Authors:
    Matuszewska M, Cieślik M, Sulejczak D, Wilkaniec A, Czapski GA
    Conference:
    The 15th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS, Warsaw, Poland (rok: 2022, ), Wydawca: Termedia
    Data:
    konferencja 20-22.10.2022
    Status:
    Published
  3. The lipopolysaccharide‑evoked systemic inflammatory response enhances the transcription of CD33 in the mouse hippocampus; the role of the BET proteins
    Authors:
    Czapski GA, Matuszewska M, Cieślik M, Strosznajder JB
    Conference:
    16th International Congress of the Polish Neuroscience Society (rok: 2023, ), Wydawca: Polish Neuroscience Society (PNS)
    Data:
    konferencja 20-23.09.2023
    Status:
    Published
  4. The role of BET proteins in controlling the phagocytic activity of microglia
    Authors:
    Matuszewska M, Cieślik M, Wilkaniec A, Czapski GA.
    Conference:
    Neuropatologia. Neuroscience. (rok: 2021, ), Wydawca: Folia Neuropathol., Termedia
    Data:
    konferencja 19.11.2021
    Status:
    Published
  5. Microglia and their contribution to the pathomechanism of Alzheimer's disease
    Authors:
    Grzegorz A. Czapski, Joanna B. Strosznajder
    Conference:
    FENS Regional Meeting 2021 (rok: 2021, ), Wydawca: Polish Neuroscience Society (PNS), Lithuanian Neuroscience Association (LNA)
    Data:
    konferencja 25-27.08.2021
    Status:
    Published
  6. Inhibition of bromodomain and extraterminal (BET) proteins modulates the expression of Alzheimer's disease risk genes in microglia
    Authors:
    Czapski GA, Matuszewska M, Cieślik M, Wilkaniec A
    Conference:
    FENS Forum, Paris, France (rok: 2022, ), Wydawca: FENS, the Federation of European Neuroscience Societies
    Data:
    konferencja 09-13.07.2022
    Status:
    Published
  7. Inhibitor of bromodomain and extraterminal (BET) proteins OTX-015 affects amyloidogenesis in aged mice
    Authors:
    Marta Matuszewska, Anna Wilkaniec, Magdalena Gąssowska, Elżbieta Gawinek, Grzegorz A. Czapski
    Conference:
    NEUROPATOLOGIA 2023 (rok: 2023, ), Wydawca: Termedia
    Data:
    konferencja 17-18.11.2023
    Status:
    Published
  8. Cerebral and peripheral response to maternal immune activation by viral mimetic; the relevance to Alzheimer's disease
    Authors:
    Matuszewska M, Wilkaniec A, Gąssowska-Dobrowolska M, Cieślik M, Sulejczak D, Czapski GA
    Conference:
    ISN‐ESN 2023 Meeting, Porto, Portugal, 8‐11 August 2023 (rok: 2023, ), Wydawca: WILEY
    Data:
    konferencja 8-11.08.2023
    Status:
    Published
  9. Inhibition of bromodomain and extraterminal proteins attenuates microglial phagocytosis
    Authors:
    Matuszewska M, Cieślik M, Wilkaniec A, Czapski GA
    Conference:
    ISN-APSN Meeting, Honolulu, Stany Zjednoczone (rok: 2022, ), Wydawca: WILEY
    Data:
    konferencja 28.08.2022-01.09.2022
    Status:
    Published

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