Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Functional, epigenetic and genetic aspects of base excision repair pathway in Alzheimer's disease

2012/05/B/NZ7/03032

Keywords:

Alzheimer's disease base excision repair pathway 8-oxo-dG genetic polymorphism DNA methylation gene expression

Descriptors:

  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

UNIWERSYTET ŁÓDZKI, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Śliwiński 

Number of co-investigators in the project: 6

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 479 709 PLN

Project start date (Y-m-d): 2013-02-12

Project end date (Y-m-d): 2016-02-11

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (1)
  1. Associations between DNA damage, DNA base excision repair genes variability and Alzheimer's disease risk.
    Authors:
    Kwiatkowski D, Czarny P, Toma M, Jurkowska N, Sliwinska A, Drzewoski J, Bachurska A, Szemraj J, Maes M, Berk M, Su K, Galecki P, Sliwinski T
    Academic press:
    Dement Geriatr Cogn Disord. (rok: 2016, tom: 41(3-4), strony: 152-171), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000443953 - link to the publication
  2. The levels of 7,8-dihydrodeoxyguanosine (8-oxoG) and 8-oxoguanine DNA glycosylase 1 (OGG1) – a potential diagnostic biomarkers of Alzheimer's disease
    Authors:
    Agnieszka Sliwinska, Dominik Kwiatkowski, Piotr Czarny, Monika Toma, Wigner Paulina, Jozef Drzewoski, Krystyna Fabianowska-Majewska, Janusz Szemraj, Michael Maes, Piotr Galecki, Tomasz Sliwinski
    Academic press:
    Journal of the Neurological Sciences (rok: 2016, tom: 368, strony: 155-159), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jns.2016.07.008 - link to the publication
  3. Variants of base excision repair genes MUTYH, PARP1 and XRCC1 in Alzheimer's disease risk
    Authors:
    Kwiatkowski D, Czarny P, Galecki P, Bachurska A, Talarowska M, Orzechowska A, Bobinska K, Bielecka-Kowalska A, Pietras T, Szemraj J, Maes M, Sliwinski T.
    Academic press:
    Neuropsychobiology (rok: 2015, tom: 71, strony: 176-186), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000381985 - link to the publication
  4. Association between single nucleotide polymorphisms of hOGG1, NEIL1, APEX1, FEN1, LIG1 and LIG3 genes and Alzheimer's disease risk.
    Authors:
    Kwiatkowski D, Czarny P, Toma M, Korycinska A, Sowinska K, Galecki P, Bachurska A, Bielecka-Kowalska A, Szemraj J, Maes M, Sliwinski T.
    Academic press:
    Neuropsychobiology (rok: 2016, tom: 73, strony: 98–107), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000444643 - link to the publication
  5. Base excision repair in Alzheimer's disease.
    Authors:
    Kwiatkowski D, Sliwiński T.
    Academic press:
    Postepy Hig Med Dosw (Online) (rok: 2014, tom: 68, strony: 976-86), Wydawca: Index Copernicus International
    Status:
    Published
    DOI:
    10.5604/17322693.1114036 - link to the publication
  1. Polymorphisms in base excision repair genes and Alzheimer's disease risk
    Authors:
    Dominik Kwiatkowski , Piotr Czarny , Sylwia Stelmach , Piotr Gałecki , Agnieszka Bachurska , Monika Talarowska, Agata Orzechowska, Anna Bielecka- Kowalska, Janusz Szemraj, Tomasz Śliwiński
    Conference:
    BIO 2014 Congress (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12 września 2014
    Status:
    Published
    DOI:
    link to the publication

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