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51. Psychedelics as Therapeutic Candidates in Neurodegenerative Disorders Treatment– a Study in Spinocerebellar Ataxia Type …

Principal investigator: dr Urszula Joanna Kozłowska

Instytut Chemii Bioorganicznej PAN

Call: SONATINA 5, Panel: NZ4

52. Aggregates of toxic polyglycine protein: in the spotlight. Understanding of formation and degradation processes.

Principal investigator: dr Magdalena Maria Derbis

Instytut Chemii Bioorganicznej PAN

Call: SONATINA 5, Panel: NZ3

53. Identification of cancer-driver mutations in non-coding parts of protein-coding genes and long non-coding RNA genes

Principal investigator: prof. Piotr Kozłowski

Instytut Chemii Bioorganicznej PAN

Call: OPUS 20, Panel: NZ5

54. Cell-based high-throughput screening for small-molecule compounds diminishing molecular markers of pathogenesis in myoto…

Principal investigator: dr hab. Marzena Wojciechowska

Instytut Chemii Bioorganicznej PAN

Call: OPUS 20, Panel: NZ3

55. Transcriptome-wide analysis of RNA structure in the cell and across cellularcompartments, and identification of the impa…

Principal investigator: dr hab. Katarzyna Pachulska-Wieczorek

Instytut Chemii Bioorganicznej PAN

Call: OPUS 20, Panel: NZ3

56. Molecular basis of glucosinolate modification and activation in the immunity of Brassicaceae species

Principal investigator: prof. Paweł Bednarek

Instytut Chemii Bioorganicznej PAN

Call: OPUS 20, Panel: NZ2

57. Anti-cancer strategy based on the induced G-quadruplex formation. Structural and biological properties of ligand-RNA/mRN…

Principal investigator: dr Dorota Gudanis-Sobocińska

Instytut Chemii Bioorganicznej PAN

Call: SONATA 16, Panel: ST4

58. Long noncoding RNA - new aim of anti-influenza therapy

Principal investigator: dr Marta Soszyńska-Jóźwiak

Instytut Chemii Bioorganicznej PAN

Call: SONATA 16, Panel: NZ6

59. The effect of cancer somatic mutations in miRNA genes on the functioning of these genes and their potential role in canc…

Principal investigator: dr Paulina Małgorzata Gałka-Marciniak

Instytut Chemii Bioorganicznej PAN

Call: SONATA 16, Panel: NZ2

60. Input of the structure of influenza A virus RNA on regulation of virus proliferation. High throughput screening of small…

Principal investigator: prof. Elżbieta Beata Kierzek

Instytut Chemii Bioorganicznej PAN

Call: OPUS 20, Panel: NZ1

61. ABCG driven transport of phenylpropanoids in Medicago truncatula - a versatile but adapted scenario.

Principal investigator: prof. Michał Jasiński

Instytut Chemii Bioorganicznej PAN

Call: OPUS 20, Panel: NZ9

62. Lanthanide binding oligonucleotides (LBOs) as paramagnetic tags for NMR spectroscopy of nucleic acids

Principal investigator: dr Witold Jacek Andrałojć

Instytut Chemii Bioorganicznej PAN

Call: OPUS 19, Panel: ST4

63. Non-coding RNAs at single-cell resolution in the pituitary gland and their role in the regulation of gene expression

Principal investigator: dr hab. Monika Piwecka

Instytut Chemii Bioorganicznej PAN

Call: OPUS 19, Panel: NZ3

64. Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en…

Principal investigator: prof. Mariusz Jaskólski

Instytut Chemii Bioorganicznej PAN

Call: OPUS 19, Panel: NZ1

65. Application of small compounds in the epigenetic therapy of malignant brain gliomas

Principal investigator: prof. Mirosława Zofia Naskręt-Barciszewska

Instytut Chemii Bioorganicznej PAN

Call: OPUS 19, Panel: NZ5

66. Foldback triplex-forming oligonucleotides as novel tools for G-quadruplex unfolding and selective inhibition of c-Myc on…

Principal investigator: prof. Anna Pasternak

Instytut Chemii Bioorganicznej PAN

Call: OPUS 19, Panel: NZ7

67. The use of genome editing systems in experimental therapy of polyglutamine diseases

Principal investigator: Magdalena Dąbrowska

Instytut Chemii Bioorganicznej PAN

Call: ETIUDA 8, Panel: NZ2

68. Antibiotic resistance genes and integrons as indicators of biotic pollution and resistance load of Arctic ecosystems

Principal investigator: dr Nicoletta Diana Makowska-Zawierucha

Instytut Chemii Bioorganicznej PAN

Call: SONATINA 4, Panel: NZ9

69. Interspecies metabolic engineering as a tool to investigate immune functions of plant specialized metabolites.

Principal investigator: prof. Paweł Bednarek

Instytut Chemii Bioorganicznej PAN

Call: OPUS 18, Panel: NZ1

70. Arc as a neuronal Gag. Exploring the viral properties and functions of a master regulator of synaptic plasticity.

Principal investigator: dr Julita Gumna

Instytut Chemii Bioorganicznej PAN

Call: PRELUDIUM 18, Panel: NZ1

71. Comprehensive analysis of the Schmidtea mediterranea transcriptome – identification of non-coding RNAs involved in cell …

Principal investigator: dr hab. Paulina Maria Jackowiak

Instytut Chemii Bioorganicznej PAN

Call: OPUS 18, Panel: NZ2

72. Chemical architecture of fluorinated nucleoside dimers containing 1,2,3-triazole linker of potential use in molecular bi…

Principal investigator: dr Dagmara Baraniak

Instytut Chemii Bioorganicznej PAN

Call: SONATA 15, Panel: NZ7

73. Allele-selective therapy for polyglutamine diseases with the use of RNA interference technology

Principal investigator: prof. Marta Olejniczak

Instytut Chemii Bioorganicznej PAN

Call: PRELUDIUM BIS 1, Panel: NZ1

74. Novel bispecific G-quadruplex conjugates as potential anticancer agents

Principal investigator: dr Carolina Sofia Pereira Roxo

Instytut Chemii Bioorganicznej PAN

Call: PRELUDIUM 18, Panel: NZ7

75. The G-rich sequences in the influenza A virus genome – structural features and potential biological function in viral re…

Principal investigator: dr Marta Maria Szabat

Instytut Chemii Bioorganicznej PAN

Call: SONATA 15, Panel: NZ6

76. Thermodynamic parameters and rules towards the determination of RNA folding in in vivo-like conditions. RNA folding pred…

Principal investigator: prof. Ryszard Kierzek

Instytut Chemii Bioorganicznej PAN

Call: OPUS 17, Panel: ST4

77. Defining roles of LINE-1 mRNA 5' and 3' ends in the retrotransposon biology

Principal investigator: dr hab. Zbigniew Warkocki

Instytut Chemii Bioorganicznej PAN

Call: OPUS 17, Panel: NZ1

78. Deciphering the molecular causes and consequences of circular RNAs elevated expression levels in myotonic dystrophy type…

Principal investigator: dr hab. Marzena Wojciechowska

Instytut Chemii Bioorganicznej PAN

Call: OPUS 17, Panel: NZ5

79. Poszukiwanie nowych mechanizmów neurodegeneracji w czasie rozwoju ataksji rdzeniowo-móżdżkowej typu 3 w mysim modelu kno…

Principal investigator: dr Kalina Katarzyna Wiatr

Instytut Chemii Bioorganicznej PAN

Call: ETIUDA 7, Panel: NZ3

80. Exploring second generation of nucleotide analogues containing phosphoranesulfen- or phosphoraneselenamides as new struc…

Principal investigator: dr Justyna Gołębiewska

Instytut Chemii Bioorganicznej PAN

Call: PRELUDIUM 16, Panel: ST5

81. Histidine Biosynthetic Pathway in Plants: Structural and Functional Studies as a Framework for the Design of Inhibitors …

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej PAN

Call: SONATA 14, Panel: NZ1

82. NMR structural studies of 8-17 and I-R2 DNAzymes

Principal investigator: dr Witold Jacek Andrałojć

Instytut Chemii Bioorganicznej PAN

Call: SONATA 14, Panel: ST4

83. Discovering disorders of brain development in Huntington disease as a consequence of putative total huntingtin deficienc…

Principal investigator: dr hab. Maciej Figiel

Instytut Chemii Bioorganicznej PAN

Call: OPUS 16, Panel: NZ3

84. Molecular basics of type II transmembrane serine proteases (TTSPs)-mediated activation of influenza viruses

Principal investigator: dr Paweł Zmora

Instytut Chemii Bioorganicznej PAN

Call: BEETHOVEN LIFE 1, Panel: NZ1

85. Mechanisms and developmental roles of transcription termination

Principal investigator: dr hab. Takashi Miki

Instytut Chemii Bioorganicznej PAN

Call: OPUS 16, Panel: NZ1

86. Shedding new light on genome's dark matter: identification of novel long non-coding RNAs in zebrafish

Principal investigator: dr hab. Barbara Uszczyńska-Ratajczak

Instytut Chemii Bioorganicznej PAN

Call: OPUS 16, Panel: NZ2

87. Impact of subcellular localization on the specificity of selected enzymes involved in the biosynthesis and metabolism of…

Principal investigator: dr hab. Paweł Bednarek

Instytut Chemii Bioorganicznej PAN

Call: OPUS 16, Panel: NZ3

88. Functional implications of brain-enriched circular RNAs

Principal investigator: dr Monika Piwecka

Instytut Chemii Bioorganicznej PAN

Call: SONATA BIS 8, Panel: NZ3

89. Small molecule tools to investigate local microenvironment of proteins

Principal investigator: dr Jacek Kolanowski

Instytut Chemii Bioorganicznej PAN

Call: OPUS 15, Panel: ST4

90. Investigation of DNA double-strand break repair mechanisms in microsatellite regions using the CRISPR/Cas system

Principal investigator: dr hab. Marta Olejniczak

Instytut Chemii Bioorganicznej PAN

Call: OPUS 15, Panel: NZ1

91. Pioneering structural and functional studies of miRNA G-quadruplexes

Principal investigator: dr Agnieszka Belter

Instytut Chemii Bioorganicznej PAN

Call: SONATINA 2, Panel: NZ1

92. The study of chitinolytic enzymes, aiming at constructing an artificial chitinosome.

Principal investigator: prof. Wojciech Robert Rypniewski

Instytut Chemii Bioorganicznej PAN

Call: OPUS 14, Panel: NZ1

93. Changes in the ribosomal protein composition and in the ribosome-associated small noncoding RNAs in Saccharomyces cerevi…

Principal investigator: dr hab. Kamilla Grzywacz

Instytut Chemii Bioorganicznej PAN

Call: OPUS 14, Panel: NZ1

94. Molecular basis of the selective transport fulfieled by plant ABCG proteins

Principal investigator: prof. Michał Jasiński

Instytut Chemii Bioorganicznej PAN

Call: OPUS 14, Panel: NZ1

95. Caged bioluminogenic substrates for a selective molecular imaging of biochemical parameters in cancer

Principal investigator: dr Jacek Łukasz Kolanowski

Instytut Chemii Bioorganicznej PAN

Call: SONATA 13, Panel: NZ1

96. Mechanisms of human gene expression regulation by uridilation

Principal investigator: dr hab. Zbigniew Stanisław Warkocki

Instytut Chemii Bioorganicznej PAN

Call: SONATA 13, Panel: NZ1

97. Contribution of gene copy number polymorphism to natural variation in response of Arabidopsis thaliana ecotypes to bioti…

Principal investigator: dr hab. Agnieszka Jowita Żmieńko

Instytut Chemii Bioorganicznej PAN

Call: SONATA 13, Panel: NZ2

98. The characteristic of the regulatory RNAs landscape in glioblastoma multiforme (GBM). Circular RNAs and micro RNA-like m…

Principal investigator: dr hab. Katarzyna Monika Rolle

Instytut Chemii Bioorganicznej PAN

Call: SONATA BIS 7, Panel: NZ3

99. Identification of biomolecules released by colorectal cancer cells and detected in serum or/and exosomes

Principal investigator: dr hab. Anna Wojakowska

Instytut Chemii Bioorganicznej PAN

Call: SONATA 13, Panel: NZ2

100. Development of methodology aiming at stabilisation of RNA in a hairpin form for crystallographic studies

Principal investigator: dr hab. Agnieszka Ludmiła Kiliszek

Instytut Chemii Bioorganicznej PAN

Call: SONATA BIS 7, Panel: NZ1

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