Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Allele-selective therapy for polyglutamine diseases with the use of RNA interference technology

2019/35/O/NZ1/03535

Keywords:

shRNA gene therapy RNAi SCA DRPLA

Descriptors:

  • NZ1_001:
  • NZ2_001:
  • NZ3_001:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marta Olejniczak 

Number of co-investigators in the project: 2

Call: PRELUDIUM BIS 1 - announced on 2019-09-16

Amount awarded: 532 800 PLN

Project start date (Y-m-d): 2020-10-01

Project end date (Y-m-d): 2024-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease
    Authors:
    Anna Kotowska-Zimmer , Lukasz Przybyl , Marianna Pewinska , Joanna Suszynska-Zajczyk , Dorota Wronka , Maciej Figiel , Marta Olejniczak
    Academic press:
    Molecular Therapy Nucleic Acids (rok: 2022, tom: 28, strony: 702-715), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.omtn.2022.04.031 - link to the publication
  2. Artificial miRNAs as therapeutic tools: Challenges and opportunities
    Authors:
    Anna Kotowska-Zimmer, Marianna Pewińska, Marta Olejniczak
    Academic press:
    WIREs RNA (rok: 2021, tom: 12, strony: e1640), Wydawca: Wiley Periodicals LLC
    Status:
    Published
    DOI:
    10.1002/wrna.1640 - link to the publication
  3. A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease
    Authors:
    Anna Kotowska-Zimmer , Lukasz Przybyl , Marianna Pewinska , Joanna Suszynska-Zajczyk , Dorota Wronka , Maciej Figiel , Marta Olejniczak
    Academic press:
    Molecular Therapy Nucleic Acids (rok: 2022, tom: 28, strony: 702-715), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.omtn.2022.04.031 - link to the publication
  1. I02 A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of huntington's disease
    Authors:
    M. Olejniczak, A. Kotowska-Zimmer, L. Przybyl, M. Pewinska, J. Suszynska-Zajczyk, D. Wronka, M. Figiel
    Conference:
    EHDN Abstracts 2021 (rok: 2021, tom: EHDN Plenary Meeting, strony: 92, S1, A48), Wydawca: BMJ Journals
    Data:
    konferencja 9-11.09.2021
    Status:
    Published
    DOI:
    10.1136/jnnp-2021-EHDN.116 - link to the publication
  2. I02 A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of huntington's disease
    Authors:
    M. Olejniczak, A. Kotowska-Zimmer, L. Przybyl, M. Pewinska, J. Suszynska-Zajczyk, D. Wronka, M. Figiel
    Conference:
    EHDN Abstracts 2021 (rok: 2021, tom: EHDN Plenary Meeting, strony: 92, S1, A48), Wydawca: BMJ Journals
    Data:
    konferencja 9-11.09.2021
    Status:
    Published
    DOI:
    10.1136/jnnp-2021-EHDN.116 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy