NMR structural studies of 8-17 and I-R2 DNAzymes

2018/31/D/ST4/01467

Keywords

Descriptors

ST4_3: Metody spektroskopowe i spektrometryczne
ST4_4: Struktura i architektura molekularna
ST4_13: Chemia fizyczna układów biologicznych

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Instytut Chemii Bioorganicznej PAN

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Witold Jacek Andrałojć

Number of co-investigators in the project: 2

Call

SONATA 14 – announced on 2018-09-14

Amount awarded: 744 000 PLN
Project start date: 2019-09-02
Project end date: 2024-09-01
Project duration: 60 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (4)

Experimental and computational investigations of RNA duplexes containing N7-regioisomers of adenosine and LNA-adenosine

Authors:
I. Yildirim, W. Andrałojć, A. Taghavi, D. Baranowski, Z. Gdaniec, R. Kierzek, E. Kierzek

Academic press:
Nucleic Acids Research (year: 2024, volume: 53, pages: Issue 1), Publisher: Oxford University Press

Status:
Published

DOI:
10.1093/nar/gkae1222 – link to the publication
The oligonucleotides containing N7-regioisomer of guanosine: influence on thermodynamic properties and structure of RNA duplexes

Authors:
Aleksandra Jarmolowicz, Nivedita Dutta, Witold Andralojc, Joanna Sarzynska, Grzegorz Framski, Daniel Baranowski, Jerzy Boryski, Ansuman Lahiri, Zofia Gdaniec, Elzbieta Kierzek, Ryszard Kierzek

Academic press:
RNA (year: 2024, volume: 31(1), pages: 86-99), Publisher: Cold Spring Harbor Laboratory Press

Status:
Published

DOI:
10.1261/rna.080106.124 – link to the publication
Solution Structure of a Lanthanide-binding DNA Aptamer Determined Using High Quality pseudocontact shift restraints

Authors:
Witold Andrałojć, Julia Wieruszewska, Karol Pasternak, Zofia Gdaniec

Academic press:
Chemistry – A European Journal (year: 2022, volume: 28, pages: e202202114), Publisher: WILEY-V C H VERLAG GMBH

Status:
Published

DOI:
10.1002/chem.202202114 – link to the publication
The 8-17 DNAzyme can operate in a single active structure regardless of metal ion cofactor

Authors:
Julia Wieruszewska, Aleksandra Pawłowicz, Ewa Połomska, Karol Pasternak, Zofia Gdaniec, Witold Andrałojć

Academic press:
Nature Communications (year: 2024, volume: 15, pages: 4218), Publisher: Springer Nature

Status:
Published

DOI:
10.1038/s41467-024-48638-x – link to the publication

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