Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Pioneering structural and functional studies of miRNA G-quadruplexes

2018/28/C/NZ1/00497

Keywords:

miRNAs G-tetrades quadruplexes miRNA structure and function

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_1: Molecular biology
  • NZ2_2: Genomics, transcriptomics, epigenomics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agnieszka Belter 

Number of co-investigators in the project: 3

Call: SONATINA 2 - announced on 2017-12-15

Amount awarded: 937 273 PLN

Project start date (Y-m-d): 2018-09-20

Project end date (Y-m-d): 2023-06-19

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. The model structure of the hammerhead ribozyme formed by RNAs of reciprocal chirality
    Authors:
    Wyszko E, Popenda M, Gudanis D, Sarzyńska J, Belter A, Perrigue P, Skowronek P, Rolle K, Barciszewski J
    Academic press:
    Bioscience Reports (rok: 2021, tom: 41, strony: BSR20203424), Wydawca: Elsvier
    Status:
    Published
    DOI:
    10.1042/BSR20203424 - link to the publication
  2. A new molecular mechanism of RNA circularization and the microRNA sponge formation
    Authors:
    Belter A, Popenda M, Sajek M, Woźniak T, Naskręt-Barciszewska MZ, Szachniuk M, Jurga S, Barciszewski J
    Academic press:
    Journal of Biomolecular Structure and Dynamics (rok: 2020, tom: bd, strony: 45300), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/07391102.2020.1844802 - link to the publication
  3. Biological macromolecule binding and anticancer activity of synthetic alkyne-containing l-phenylalanine derivatives
    Authors:
    Fik-Jaskółka MA, Mkrtchyan AF, Saghyan AS, Palumbo R, Belter A, Hayriyan LA, Simonyan H, Roviello V, Roviello GN
    Academic press:
    Amino Acids (rok: 2020, tom: 52, strony: 755-769), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-020-02849-w - link to the publication
  4. Spectroscopic and SEM evidences for G4-DNA binding by a synthetic alkyne-containing amino acid with anticancer activity
    Authors:
    Fik-Jaskółka M.A., Mkrtchyan A.F., Saghyan A.S., Palumbo R., Belter A.,Hayriyan L.A., Simonyan H., Roviello V., Roviello G.N.
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2020, tom: 229, strony: 117884), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2019.117884 - link to the publication

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