Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Novel bispecific G-quadruplex conjugates as potential anticancer agents

2019/35/N/NZ7/02777

Keywords:

DNA G-quadruplexes thermodynamics bispecific constructs cancer therapy antiproliferative activity

Descriptors:

  • NZ7_014:
  • NZ7_016:
  • NZ5_007:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Carolina Sofia Pereira Roxo 

Number of co-investigators in the project: 2

Call: PRELUDIUM 18 - announced on 2019-09-16

Amount awarded: 210 000 PLN

Project start date (Y-m-d): 2020-07-06

Project end date (Y-m-d): 2024-03-05

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Physicochemical and antiproliferative characteristics of RNA and DNA sequence–related G–quadruplexes
    Authors:
    Kotkowiak, W.; Roxo, C.; Pasternak, A.
    Academic press:
    ACS Medicinal Chemistry Letters (rok: 2023, tom: 14, strony: 35–40), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acsmedchemlett.2c00361 - link to the publication
  2. Changes in physicochemical and anticancer properties modulated by chemically modified sugar moieties within sequence–related G–quadruplex structures
    Authors:
    Roxo, C. ; Pasternak, A.
    Academic press:
    PLOS ONE (rok: 2022, tom: 17, strony: e0273528), Wydawca: PLOS ONE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0273528 - link to the publication
  3. Physicochemical and antiproliferative characteristics of RNA and DNA sequence–related G–quadruplexes
    Authors:
    Kotkowiak, W.; Roxo, C.; Pasternak, A.
    Academic press:
    ACS Medicinal Chemistry Letters (rok: 2023, tom: 14, strony: 35–40), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acsmedchemlett.2c00361 - link to the publication
  4. G4 matters - the Influence of G-quadruplex Structural Elements on the Antiproliferative Properties of G-rich Oligonucleotides
    Authors:
    Roxo C., Kotkowiak W., Pasternak A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4941), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094941 - link to the publication
  5. Bispecific G-quadruplexes as inhibitors of cancer cells growth
    Authors:
    Roxo C., Zielińska K., Pasternak A.
    Academic press:
    Biochimie (rok: 2023, tom: 214, strony: 91-100), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biochi.2023.08.008 - link to the publication
  6. G4 matters - the Influence of G-quadruplex Structural Elements on the Antiproliferative Properties of G-rich Oligonucleotides
    Authors:
    Roxo C., Kotkowiak W., Pasternak A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4941), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094941 - link to the publication
  7. Changes in physicochemical and anticancer properties modulated by chemically modified sugar moieties within sequence–related G–quadruplex structures
    Authors:
    Roxo, C. ; Pasternak, A.
    Academic press:
    PLOS ONE (rok: 2022, tom: 17, strony: e0273528), Wydawca: PLOS ONE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0273528 - link to the publication
  8. G4 matters - the Influence of G-quadruplex Structural Elements on the Antiproliferative Properties of G-rich Oligonucleotides
    Authors:
    Roxo C., Kotkowiak W., Pasternak A.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4941), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094941 - link to the publication

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