Projects funded by the NCN
Anti-cancer strategy based on the induced G-quadruplex formation. Structural and biological properties of ligand-RNA/mRNA complexes.
2020/39/D/ST4/03177
Keywords:
G-quadruplexes ligands chemical modifications NMR CD and UV spectroscopy inhibition of translation cancer RNA oligonucleotides
Descriptors:
- ST4_009:
- NZ1_004:
- NZ7_012:
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk
woj. wielkopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 7
Call: SONATA 16 - announced on 2020-09-15
Amount awarded: 1 174 250 PLN
Project start date (Y-m-d): 2021-09-01
Project end date (Y-m-d): 2025-08-31
Project duration:: 48 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Impact of a Single Nucleotide Change or Non-Nucleoside Modifications in G-Rich Region on the Quadruplex–Duplex Hybrid FormationAuthors:Dorota Gudanis, Karolina Zielińska, Daniel Baranowski, Ryszard Kierzek, Piotr Kozłowski, Zofia GdaniecAcademic press:Biomolecules (rok: 2021, tom: 11, strony: 1236), Wydawca: MDPIStatus:PublishedDOI:10.3390/biom11081236 - link to the publication