Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Foldback triplex-forming oligonucleotides as novel tools for G-quadruplex unfolding and selective inhibition of c-Myc oncogene transcription

2020/37/B/NZ7/02008

Keywords:

nucleic acids thermodynamics G-quadruplex triplex oncogene transcription regulation anticancer therapy cell lines

Descriptors:

  • NZ7_014:
  • NZ7_016:
  • ST4_009:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Anna Pasternak 

Number of co-investigators in the project: 4

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 1 843 200 PLN

Project start date (Y-m-d): 2021-04-01

Project end date (Y-m-d): 2026-03-31

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. A Comprehensive Analysis of the Thrombin Binding Aptamer Containing Functionalized Pyrrolo-2'-deoxycytidines
    Authors:
    Kotkowiak W., Jahnz-Wechmann Z., Pasternak A.
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 1326), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14121326 - link to the publication
  2. Beyond G-Quadruplexes—The Effect of Junction with Additional Structural Motifs on Aptamers Properties
    Authors:
    Kotkowiak W., Pasternak A.
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 22, strony: 9948), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22189948 - link to the publication
  3. Changes in physicochemical and anticancer properties modulated by chemically modified sugar moieties within sequence-related Gquadruplex structures
    Authors:
    Carolina Roxo, Anna Pasternak
    Academic press:
    PLoS ONE (rok: 2022, tom: 17, strony: e0273528), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0273528 - link to the publication
  4. Bispecific G‐quadruplexes as inhibitors of cancer cells growth
    Authors:
    Carolina Roxo, Karolina Zielińska, Anna Pasternak
    Academic press:
    Biochimie (rok: 2023, tom: 214, strony: 91-100), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biochi.2023.08.008 - link to the publication
  5. Switching off cancer – An overview of G-quadruplex and i-motif functional role in oncogene expression
    Authors:
    Carolina Roxo, Anna Pasternak
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2025, tom: 116, strony: 130038), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2024.130038 - link to the publication
  6. Evaluation of Gene Expression Knock-Down by Chemically and Structurally Modified Gapmer Antisense Oligonucleotides
    Authors:
    Jolanta Lisowiec-Wąchnicka, Mathias B. Danielsen, Eugenie Abi Nader, Per T. Jørgensen, Jesper Wengel, Anna Pasternak
    Academic press:
    ChemBioChem (rok: 2022, tom: 23, strony: e202200168), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/cbic.202200168 - link to the publication
  7. Physicochemical and antiproliferative characteristics of RNA and DNA sequence-related G‑quadruplexes
    Authors:
    Weronika Kotkowiak, Carolina Roxo, Anna Pasternak
    Academic press:
    ACS Med. Chem. Lett. (rok: 2023, tom: 14, strony: 35–40), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acsmedchemlett.2c00361 - link to the publication
  8. G4 Matters—The Influence of G-Quadruplex Structural Elements on the Antiproliferative Properties of G-Rich Oligonucleotides
    Authors:
    Roxo C., Kotkowiak W., Pasternak A.
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 22, strony: 4941), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094941 - link to the publication
  9. A Comprehensive Analysis of the Thrombin Binding Aptamer Containing Functionalized Pyrrolo-2'-deoxycytidines
    Authors:
    Kotkowiak W., Jahnz-Wechmann Z., Pasternak A.
    Academic press:
    Pharmaceuticals (rok: 2021, tom: 14, strony: 1326), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14121326 - link to the publication

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