Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Application of small compounds in the epigenetic therapy of malignant brain gliomas

2020/37/B/NZ5/03249

Keywords:

cannabidiol tetrahydrocannabinol,valproic acid metformin,dexamethasone temozolomide,8-OH-dG 5-methylocytosine glioma biomarker epigenetics senescence cancer stem cells beta-galactosidase Jmjd3 Utx

Descriptors:

  • NZ5_007:
  • NZ5_003:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mirosława Zofia Naskręt-Barciszewska 

Number of co-investigators in the project: 5

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 973 200 PLN

Project start date (Y-m-d): 2021-02-01

Project end date (Y-m-d): 2025-12-31

Project duration:: 59 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Juglone in Combination with Temozolomide Shows a Promising Epigenetic Therapeutic Effect on the Glioblastoma Cell Line
    Authors:
    Anna-Maria Barciszewska, Agnieszka Belter, Iwona Gawrońska, Małgorzata Giel-Pietraszuk, Mirosława Z. Naskręt-Barciszewska
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(8), strony: 6998), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24086998 - link to the publication
  2. Cross-reactivity between histone demethylase inhibitor valproic acid and DNA methylation in glioblastoma cell lines
    Authors:
    Anna-Maria Barciszewska, Agnieszka Belter, Iwona Gawrońska, Małgorzata Giel-Pietraszuk, Mirosława Z. Naskręt-Barciszewska
    Academic press:
    Frontiers in Oncology (rok: 2022, tom: 12, strony: 1033035), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2022.1033035 - link to the publication
  3. Cross-reactivity between histone demethylase inhibitor valproic acid and DNA methylation in glioblastoma cell lines
    Authors:
    Anna-Maria Barciszewska, Agnieszka Belter, Iwona Gawrońska, Małgorzata Giel-Pietraszuk, Mirosława Z. Naskręt-Barciszewska
    Academic press:
    Frontiers in Oncology (rok: 2022, tom: 12, strony: 1033035), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2022.1033035 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy